ChemicalBook > CAS DataBase List > 1-(Cbz-amino)cyclopropanecarboxylic acid

1-(Cbz-amino)cyclopropanecarboxylic acid

Product Name: 1-(Cbz-amino)cyclopropanecarboxylic acid
CAS No.: 84677-06-5
Chemical Name: 1-(Cbz-amino)cyclopropanecarboxylic acid
Synonyms: Z-ACPC-OH;Z-AC3C-OH;Cbz-ACPC-OH;1-(Z-amino)cycL;1-(z-amino)cyclopropanecarboxylic acid;Z-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID;1-(Cbz-amino)cyclopropanecarboxylic acid;N-Cbz-1-aMinocyclopropanecarboxylic acid;CBZ-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID;1-(N-CBZ-AMINO)CYCLO-PROPANECARBOXYLIC ACID
CBNumber: CB1349236
Molecular Formula: C12H13NO4
Formula Weight: 235.24
MOL File: 84677-06-5.mol

Less

1-(Cbz-amino)cyclopropanecarboxylic acid Property

Melting point:: 157.0 to 161.0 °C
Boiling point:: 449.0±34.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: soluble in Methanol
form: powder to crystal
pka: 4.02±0.20(Predicted)
color: White to Almost white
CAS DataBase Reference: 84677-06-5(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2924297099

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C7047
Product name: 1-(Z-amino)cyclopropanecarboxylic acid
Packaging: 500mg
Price: $430
Updated: 2025/07/31

TCI Chemical

Product number: C2680
Product name: 1-(Carbobenzoxyamino)cyclopropanecarboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: C2680
Product name: 1-(Carbobenzoxyamino)cyclopropanecarboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $129
Updated: 2025/07/31

TRC

Product number: B130013
Product name: 1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylicAcid
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 261303
Product name: Z-1-aminocyclopropane-1-carboxylic acid
Packaging: 2g
Price: $345
Updated: 2021/12/16

Less

1-(Cbz-amino)cyclopropanecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylic Acid is a useful intermediate used in the preparation of the analogs of vasopressins and other peptide derivatives.

Synthesis

13139-17-8

22059-21-8

84677-06-5

Step A: Synthesis of intermediate VI A tetrahydrofuran (THF, 500 mL) solution of benzyl 2,5-dioxopyrrolidin-1-yl carbonate (83 g, 334 mmol) was added slowly and dropwise to an aqueous (500 mL) solution of 1-aminocyclopropanecarboxylic acid (25 g, 247 mmol). A solution of sodium bicarbonate (91 g, 1088 mmol) in water (500 mL) was added dropwise to the reaction mixture under cooling in an ice bath. After the dropwise addition, the reaction system was slowly warmed to room temperature and the reaction was continued with stirring for 16 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was resuspended in dichloromethane (200 mL) and extracted with water (500 mL). The aqueous phase was acidified by acetic acid and the precipitated white solid was collected by filtration to afford 1-((benzyloxy)carbonyl)amino)cyclopropanecarboxylic acid (53 g, 171 mmol, 69.2% yield). The crude product can be directly used in the next step of the reaction.LC/MS analysis result: m/z calculated value 235.1, measured value 258.0 ([M+Na]+).

References

[1] Synlett, 2004, # 14, p. 2489 - 2492
[2] Patent: WO2013/20245, 2013, A1. Location in patent: Paragraph 00105
[3] Patent: WO2015/95227, 2015, A2. Location in patent: Page/Page column 220; 221

1-(Cbz-amino)cyclopropanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Less

1-(Cbz-amino)cyclopropanecarboxylic acid Suppliers

Americas 1 China 132 Europe 2 Germany 4 India 2 Japan 3 Switzerland 1 United Kingdom 4 United States 14 Global 163

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai Hong-chuang Pharma Tech Co., Ltd.

Tel: 18151128828
Fax: -
Email: hc-sales@foxmail.com
Country: China
ProdList: 2647
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3853
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 13096311329 028-88469284 616445927
Fax: 028-88469284
Email: 616445927@qq.com
Country: China
ProdList: 2874
Advantage: 50

Nanjing Derno Pharmaceutical Technology Co., Ltd.

Tel: 025-86957866 13952093866
Fax: 025-68661287
Email: sales@dernopharm.com
Country: China
ProdList: 932
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shijiazhuang Moyi Chemical Technology Co., Ltd

Tel: 0311-85511132 18031831025
Email: mingyu2011p@126.com
Country: China
ProdList: 86
Advantage: 55

Nanijing m&m biotechnology Co. ,Ltd.

Tel: 025-87782433 18021532344
Fax: 025-87782433
Email: 1345332203@qq.com
Country: China
ProdList: 4134
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Shanghai YuMei Pharmaceutical Chemical Co., Ltd.

Tel: 13661490451 13671802554
Fax: QQ627235036
Email: xyfn@163.com
Country: China
ProdList: 582
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Less

View Lastest Price from 1-(Cbz-amino)cyclopropanecarboxylic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylic acid 84677-06-5
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-(Cbz-amino)cyclopropanecarboxylic acid 84677-06-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Dideu Industries Group Limited

Product: 1-(Cbz-amino)cyclopropanecarboxylic acid 84677-06-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-06-11

84677-06-5, 1-(Cbz-amino)cyclopropanecarboxylic acidRelated Search:

Glycine Folic acid 1-Aminocyclopropanecarboxylic acid Glucosamine ALTRENOGEST (Bromomethyl)cyclopropane Ethyl 2-(Chlorosulfonyl)acetate Cyclopropane Sulfamic acid Acetaminophen EC 2.6.1.2 Cyclopropyl bromide Cyclopropanecarboxylic acid Cyclopropylamine Citric acid Ascoric Acid NICKEL CARBONYL Ethyleneimine

N-Benzyloxycarbonyl-1-aminocyclopropanecarboxylic

Cyclopropanecarboxylic acid, 1-[[(phenylmethoxy)carbonyl]amino]- (9CI)

1-(z-amino)cyclopropanecarboxylic acid

N-Benzyloxycarbonyl-1-aminocyclopropanecarboxylic acid

1-Benzyloxycarbonylaminocyclopropanecarboxylic acid

1-(Cbz-amino)cyclopropanecarboxylic acid

1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylic acid 95+%

1-(phenylmethoxycarbonylamino)-1-cyclopropanecarboxylic acid

Cyclopropanecarboxylic acid, 1-[[(phenylMethoxy)carbonyl]aMino]-

1-(CarbobenzoxyaMino)cyclopropanecarboxylic Acid

N-Cbz-1-aMinocyclopropanecarboxylic acid

CBZ-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID

Cbz-ACPC-OH

Z-1-aminocyclopropane-1-carboxylic acid≥ 99% (HPLC)

1-(N-CBZ-AMINO)CYCLO-PROPANECARBOXYLIC ACID

Z-ACPC-OH

Z-AC3C-OH

Z-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID

1-Benzyloxycarbonylaminocyclopropanecarboxylicaci

1-(phenylmethoxycarbonylamino)cyclopropane-1-carboxylic acid

1-(BENZYLOXYCARBONYL-AMINO)-CYCLOPROPYL-1-CARBOXYLIC ACID

1-(Carbobenzoxyamino)cyclopropanecarboxylic Acid &gt

1-(Z-amino)cycL

1-(Cbz-amino)cyclopropanecarboxylic acid USP/EP/BP

84677-06-5

I - Z

Modified Amino Acids

Biochemicals and Reagents

BioChemical

Amino Acids and Peptides

Amino Acids

I - Z

Modified Amino Acids

Amino Acid Derivatives

N-CBZ