Cyclopropylamine

ChemicalBook > CAS DataBase List > Cyclopropylamine

Product Name: Cyclopropylamine
CAS No.: 765-30-0
Chemical Name: Cyclopropylamine
Synonyms: Cyclopropanamine;AMINOCYCLOPROPANE;AURORA KA-2551;Cylopropylamine;Cydopropylamine;Cyloprolylamine;CYCLOPROPYLAMINE;Ring propylaMine;AKOS BBS-00003593;AMINOTRIMETHYLENE
CBNumber: CB1782699
Molecular Formula: C3H7N
Formula Weight: 57.09
MOL File: 765-30-0.mol

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Cyclopropylamine Property

Melting point:: -50 °C
Boiling point:: 49-50 °C (lit.)
Density: 0.824 g/mL at 25 °C (lit.)
vapor pressure: 4.67 psi ( 20 °C)
refractive index: n20/D 1.420(lit.)
Flash point:: −14 °F
storage temp.: Store below +30°C.
solubility: Chloroform, Ethyl Acetate (Sparingly), Methanol (Slightly)
pka: pK1:9.10(+1) (25°C)
form: Volatile Liquid
color: Clear colorless
Specific Gravity: 0.824
Water Solubility: Miscible with water, ethanol,ether and chloroform.
Sensitive: Lachrymatory
BRN: 741858
Stability:: Volatile
InChIKey: HTJDQJBWANPRPF-UHFFFAOYSA-N
LogP: 0.070
CAS DataBase Reference: 765-30-0(CAS DataBase Reference)
NIST Chemistry Reference: Cyclopropylamine(765-30-0)
EPA Substance Registry System: Cyclopropanamine (765-30-0)

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Safety

Hazard Codes: F,C,Xi
Risk Statements: 11-22-34-36/37
Safety Statements: 16-26-36/37/39-45-33-7/9
RIDADR: UN 2733 3/PG 2
WGK Germany: 2
RTECS: GZ0685500
Autoignition Temperature: 527 °F
Hazard Note: Extremely Flammable/Harmful/Corrosive/Lachrymatory
TSCA: T
HazardClass: 3
PackingGroup: II
HS Code: 29213099
Toxicity: LD50 orally in Rabbit: 445 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.18017
Product name: Cyclopropylamine
Purity: for synthesis
Packaging: 10ml
Price: $38.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.18017
Product name: Cyclopropylamine
Purity: for synthesis
Packaging: 100mL
Price: $290
Updated: 2024/03/01

Sigma-Aldrich

Product number: 125504
Product name: Cyclopropylamine
Purity: 98%
Packaging: 10g
Price: $44.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 125504
Product name: Cyclopropylamine
Purity: 98%
Packaging: 25g
Price: $89.7
Updated: 2024/03/01

TCI Chemical

Product number: C0981
Product name: Cyclopropylamine
Purity: >95.0%(GC)(T)
Packaging: 5mL
Price: $20
Updated: 2024/03/01

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Cyclopropylamine Chemical Properties,Usage,Production

Chemical Properties

Cyclopropylamine is a colorless and transparent flammable liquid with volatility and ammonia odor. It is miscible with water, methanol, ethanol, benzene, toluene and other solvents.

Uses

Cyclopropylamine is used in the preparation of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It is also used to prepare Pt(CPA)2(bismethylthiomethylenepropanedioate) and Pt(CPA)2(bisethylthiomethylenepropanedioate) complexes.

Definition

ChEBI: Cyclopropylamine is a primary aliphatic amine that consists of cyclopropane bearing a single amino substituent. It has a role as a mouse metabolite.

Application

Cyclopropylamine is mainly used in organic synthesis, pharmaceutical synthesis intermediates, and can be used in the synthesis of new antibacterial drugs ciprofloxacin products, such as the synthesis of ciprofloxacin, enrofloxacin, spafloxacin and other drugs. In addition, cyclopropylamine is also an important intermediate for the synthesis of pesticides, plant protection agents and herbicides, such as 2-chloro-4-6-cyclopropyl-s-triazine, cyprochlor, cyproterazine, cyprocyanine and other cyclopropanes class of pesticides.

Preparation

Cyclopropylamine is synthesized from 1,3-propanediol by bromination, cyanation, cyclization, amidation, and Hoffmann rearrangement. It is also synthesized with γ-butyrolactone and isopropanol by five steps of ring-opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation.

Biochem/physiol Actions

Cyclopropylamine inactivates cytochrome P450 enzymes by a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. It is a mechanism-based inhibitor of quinoprotein methylamine dehydrogenase from Paracoccus denitrificans.

Purification Methods

It has been isolated as the benzamide m 100.6-101.0o (from aqueous EtOH). It forms a picrate m 149o (from EtOH/pet ether) from which the free base can be recovered using a basic ion-exchange resin and can then be distilled through a Todd column (p 11) using an automatic still head which only collects products boiling below 51o/atm. Polymeric materials if present will boil above this temperature. The hydrochloride has m 85-86o [Roberts & Chambers J Am Chem Soc 73 5030 1951, Jones J Org Chem 9 484 1944, Emmons J Am Chem Soc 79 6522 1957]. [Beilstein 12 IV 3.]

Cyclopropylamine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate CHLORIC ACID Sodium hypochlorite 1,3-Propanediol Sodium Methoxide Gamma Butyrolactone

Preparation Products

1-CYCLOPROPYLPIPERAZINE 4-CHLORO-3-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE Ciprofloxacin hydrochloride Cyromazine 3-BROMO-2-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid ETHYL 3-(CYCLOPROPYLAMINO)ACRYLATE 1-(3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)PHENYL)ETHANONE 2-N-Cyclopropylamino-4,6-DichloroTriazine 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid Enrofloxacin hydrochloride Ciprofloxacin Sparfloxacin 3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid

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View Lastest Price from Cyclopropylamine manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Cyclopropylamine 765-30-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 10 ton
Release date: 2024-08-23

Wuhan Xinhao Biotechnology Co., Ltd

Product: Cyclopropylamine 765-30-0
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2024-03-12

Changzhou Rokechem Technology Co., Ltd.

Product: Cyclopropylamine 765-30-0
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99%
Supply Ability: 1-10000kgs
Release date: 2023-09-11

765-30-0, CyclopropylamineRelated Search:

Tranylcypromine Isopropylamine Diisopropylamine (-)-2-[METHYLAMINO]-1-PHENYLPROPANE TRANS-2-PHENYLCYCLOPROPYL ISOCYANATE D/L-AMPHETAMINE HYDROCHLORIDE Ciprofloxacin Rolicyprine Lorbamate Cyromazine CYCLOPROPYL ISOTHIOCYANATE 1-Aminocyclopropanecarboxylic acid 1-Aminocyclopropane-1-carboxylic acid hydrochloride Methyl 1-aminocyclopropanecarboxylate hydrochloride 1-(Cbz-amino)cyclopropanecarboxylic acid Tranylcypromine Hemisulfate tranylcypromine 1-BOC-3-AMINOPIPERIDINE

Cyclopropanamine

CYCLOPROPYLAMINE

AURORA KA-2551

AKOS BBS-00003593

AMINOCYCLOPROPANE

AMINOTRIMETHYLENE

Cyloprolylamine

Cyclopropyl amine(CPA)

Cydopropylamine

Cyclopropylamine,98%

Cylopropylamine

Cyclopropylamine 98%

CYCLOPROPYLAMINE W/O STABILIZING AGENT

CYCLOPROPYLAMINE W/STABILIZING AGENT

Cyclopropylamine ,99%

1-Cyclopropanamine

Cyclopropylamine,Aminocyclopropane

CyclopropylaMine, 98% 25ML

CyclopropylaMine, 99% 10ML

CyclopropylaMine, 99% 50ML

CYCLOPROPYLAMINE FOR SYNTHESIS

CyclopropylaMine, 97+%

Ring propylaMine

Moxifloxacin Impurity 43

Cyclopropylamine &gt

1-cyclopropyl-6,7-difluoro-8-methoxyquinolin-4(1H)-one

Cyclopropylamine (6CI, 7CI, 8CI)

765-30-0

65-30-0

C3H7N

C3H5NH2

Simple 3-Membered Ring Compounds

Cyclopropanes

AMINE

Building Blocks

Amines

C2 to C6

Organic Building Blocks

Nitrogen Compounds

Pharmaceutical Intermediates

Cyclopropanes

Simple 3-Membered Ring Compounds