ChemicalBook > CAS DataBase List > Cyclopropylamine

Cyclopropylamine

Product Name
Cyclopropylamine
CAS No.
765-30-0
Chemical Name
Cyclopropylamine
Synonyms
Cyclopropanamine;AMINOCYCLOPROPANE;AURORA KA-2551;Cylopropylamine;Cydopropylamine;Cyloprolylamine;CYCLOPROPYLAMINE;Ring propylaMine;AKOS BBS-00003593;AMINOTRIMETHYLENE
CBNumber
CB1782699
Molecular Formula
C3H7N
Formula Weight
57.09
MOL File
765-30-0.mol
More
Less

Cyclopropylamine Property

Melting point:
-50 °C
Boiling point:
49-50 °C (lit.)
Density 
0.824 g/mL at 25 °C (lit.)
vapor pressure 
4.67 psi ( 20 °C)
refractive index 
n20/D 1.420(lit.)
Flash point:
−14 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform, Ethyl Acetate (Sparingly), Methanol (Slightly)
pka
pK1:9.10(+1) (25°C)
form 
Volatile Liquid
color 
Clear colorless
Specific Gravity
0.824
Water Solubility 
Miscible with water, ethanol,ether and chloroform.
Sensitive 
Lachrymatory
BRN 
741858
Stability:
Volatile
InChIKey
HTJDQJBWANPRPF-UHFFFAOYSA-N
LogP
0.070
CAS DataBase Reference
765-30-0(CAS DataBase Reference)
NIST Chemistry Reference
Cyclopropylamine(765-30-0)
EPA Substance Registry System
Cyclopropanamine (765-30-0)
More
Less

Safety

Hazard Codes 
F,C,Xi
Risk Statements 
11-22-34-36/37
Safety Statements 
16-26-36/37/39-45-33-7/9
RIDADR 
UN 2733 3/PG 2
WGK Germany 
2
RTECS 
GZ0685500
Autoignition Temperature
527 °F
Hazard Note 
Extremely Flammable/Harmful/Corrosive/Lachrymatory
TSCA 
T
HazardClass 
3
PackingGroup 
II
HS Code 
29213099
Toxicity
LD50 orally in Rabbit: 445 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.18017
Product name
Cyclopropylamine
Purity
for synthesis
Packaging
10ml
Price
$38.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18017
Product name
Cyclopropylamine
Purity
for synthesis
Packaging
100mL
Price
$290
Updated
2024/03/01
Sigma-Aldrich
Product number
125504
Product name
Cyclopropylamine
Purity
98%
Packaging
10g
Price
$44.6
Updated
2024/03/01
Sigma-Aldrich
Product number
125504
Product name
Cyclopropylamine
Purity
98%
Packaging
25g
Price
$89.7
Updated
2024/03/01
TCI Chemical
Product number
C0981
Product name
Cyclopropylamine
Purity
>95.0%(GC)(T)
Packaging
5mL
Price
$20
Updated
2024/03/01
More
Less

Cyclopropylamine Chemical Properties,Usage,Production

Chemical Properties

Cyclopropylamine is a colorless and transparent flammable liquid with volatility and ammonia odor. It is miscible with water, methanol, ethanol, benzene, toluene and other solvents.

Uses

Cyclopropylamine is used in the preparation of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It is also used to prepare Pt(CPA)2(bismethylthiomethylenepropanedioate) and Pt(CPA)2(bisethylthiomethylenepropanedioate) complexes.

Definition

ChEBI: Cyclopropylamine is a primary aliphatic amine that consists of cyclopropane bearing a single amino substituent. It has a role as a mouse metabolite.

Application

Cyclopropylamine is mainly used in organic synthesis, pharmaceutical synthesis intermediates, and can be used in the synthesis of new antibacterial drugs ciprofloxacin products, such as the synthesis of ciprofloxacin, enrofloxacin, spafloxacin and other drugs. In addition, cyclopropylamine is also an important intermediate for the synthesis of pesticides, plant protection agents and herbicides, such as 2-chloro-4-6-cyclopropyl-s-triazine, cyprochlor, cyproterazine, cyprocyanine and other cyclopropanes class of pesticides.

Preparation

Cyclopropylamine is synthesized from 1,3-propanediol by bromination, cyanation, cyclization, amidation, and Hoffmann rearrangement. It is also synthesized with γ-butyrolactone and isopropanol by five steps of ring-opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation.

Biochem/physiol Actions

Cyclopropylamine inactivates cytochrome P450 enzymes by a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. It is a mechanism-based inhibitor of quinoprotein methylamine dehydrogenase from Paracoccus denitrificans.

Purification Methods

It has been isolated as the benzamide m 100.6-101.0o (from aqueous EtOH). It forms a picrate m 149o (from EtOH/pet ether) from which the free base can be recovered using a basic ion-exchange resin and can then be distilled through a Todd column (p 11) using an automatic still head which only collects products boiling below 51o/atm. Polymeric materials if present will boil above this temperature. The hydrochloride has m 85-86o [Roberts & Chambers J Am Chem Soc 73 5030 1951, Jones J Org Chem 9 484 1944, Emmons J Am Chem Soc 79 6522 1957]. [Beilstein 12 IV 3.]

Cyclopropylamine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate CHLORIC ACID Sodium hypochlorite 1,3-Propanediol Sodium Methoxide Gamma Butyrolactone

Preparation Products

1-CYCLOPROPYLPIPERAZINE 4-CHLORO-3-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE Ciprofloxacin hydrochloride Cyromazine 3-BROMO-2-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid ETHYL 3-(CYCLOPROPYLAMINO)ACRYLATE 1-(3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)PHENYL)ETHANONE 2-N-Cyclopropylamino-4,6-DichloroTriazine 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid Enrofloxacin hydrochloride Ciprofloxacin Sparfloxacin 3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid
More
Less

Cyclopropylamine Suppliers

Americas 1 Austria 1 Belgium 4 Canada 2 China 375 Europe 4 France 4 Germany 10 India 73 Japan 6 Russia 1 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 19 United States 57 Global 561
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
GLR Innovations
Tel
+91 9891111994
Email
info@glrgroup.in
Country
India
ProdList
4535
Advantage
58
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
SGMR Pharmaceuiticals Pvt Ltd
Tel
--
Fax
--
Email
api.marketing@sgmrpharma.com
Country
India
ProdList
51
Advantage
58
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
Kkyemistry (india) Pvt., Ltd.
Tel
--
Fax
--
Email
marketing@kyemistryindia.com
Country
India
ProdList
163
Advantage
58
Orbit Lifescience Pvt., Ltd.
Tel
--
Fax
--
Email
orbit@orbitlifescience.com
Country
India
ProdList
206
Advantage
58
Chemrich Fine Chemicals Pvt., Ltd.
Tel
--
Fax
--
Email
info@chemrichfine.com
Country
India
ProdList
399
Advantage
58
Clearsynth Labs
Tel
--
Fax
--
Email
fo@clearsynth.com
Country
India
ProdList
3887
Advantage
58
Bizten Impex Private Limited
Tel
--
Fax
--
Country
India
ProdList
71
Advantage
58
ASM Organics
Tel
--
Fax
--
Country
India
ProdList
1185
Advantage
58
Azole Rasayanas India Private Limited
Tel
--
Fax
--
Email
info@azolerasayanas.com
Country
India
ProdList
681
Advantage
58
Synergy United Pharmachem Pvt., Ltd.
Tel
--
Fax
--
Email
info@synergyunited.in
Country
India
ProdList
27
Advantage
58
Virchow Laboratories Limited
Tel
--
Fax
--
Country
India
ProdList
31
Advantage
58
Trignokem International.
Tel
--
Fax
--
Email
ignokem@gmail.com
Country
India
ProdList
233
Advantage
58
Trignokem International
Tel
--
Fax
--
Country
India
ProdList
110
Advantage
58
Sudarshan Pharma Industries Limited.
Tel
--
Fax
--
Email
@sudarshangrp.com
Country
India
ProdList
157
Advantage
58
SM Chem Associates
Tel
--
Fax
--
Email
sastry@smchemassociates.com
Country
India
ProdList
84
Advantage
58
Vestro Solvents Pvt. Ltd.
Tel
--
Fax
--
Email
vestrosolvents@yahoo.co.in
Country
India
ProdList
24
Advantage
58
Parth Antibiotics Pvt., Ltd.
Tel
--
Fax
--
Email
info@parthantibiotics.com
Country
India
ProdList
137
Advantage
58
Bizten Impex Private Limited.
Tel
--
Fax
--
Country
India
ProdList
109
Advantage
58
VASIN BIO LIFE SCIENCES PVT LTD
Tel
--
Fax
--
Email
info@vasinbio.com
Country
India
ProdList
2092
Advantage
58
G C Int'L
Tel
--
Fax
--
Email
gcintl@gmail.com
Country
India
ProdList
125
Advantage
58
Unitrade Agencies
Tel
--
Fax
--
Country
India
ProdList
197
Advantage
58
Shilpa Chemspec International Pvt. Ltd.
Tel
--
Fax
--
Country
India
ProdList
20
Advantage
58
New Rise Life Science
Tel
--
Fax
--
Email
info@newriselifescience.com
Country
India
ProdList
150
Advantage
58
Popawala Chemicals Pvt. Ltd
Tel
--
Fax
--
Country
India
ProdList
24
Advantage
58
Vapoor Chemicals
Tel
--
Fax
--
Email
vapoor@vapoorchemicals.com
Country
India
ProdList
71
Advantage
58
Refarmed Chemicals India Pvt. Ltd
Tel
--
Fax
--
Country
India
ProdList
3
Advantage
58
Antares Chem Private Limited
Tel
--
Fax
--
Country
India
ProdList
179
Advantage
58
Sai Quest Syn. Ltd
Tel
--
Fax
--
Country
India
ProdList
268
Advantage
58
Renuka Interchem
Tel
--
Fax
--
Country
India
ProdList
116
Advantage
58
Oceanic Pharmachem Pvt. Ltd.
Tel
--
Fax
--
Email
info@oceanicpharmachem.com
Country
India
ProdList
2005
Advantage
58
EMMENNAR PHARMA PRIVATE LTD
Tel
--
Fax
--
Email
sales@emmennar.com
Country
India
ProdList
26
Advantage
58
AARTI DRUGS LTD
Tel
--
Fax
--
Email
export@aartidrugs.com
Country
India
ProdList
40
Advantage
58
Anu`s Laboratories Limited
Tel
--
Fax
--
Country
India
ProdList
16
Advantage
58
HiMedia Laboratories
Tel
--
Fax
--
Email
o@himedialabs.com
Country
India
ProdList
1841
Advantage
58
Deep Prabha Transchem
Tel
--
Fax
--
Email
dipen@deepprabha.com
Country
India
ProdList
108
Advantage
58
Sanjay Chemicals (India) Pvt., Ltd.
Tel
--
Fax
--
Email
abdul@sanjaychemindia.com
Country
India
ProdList
159
Advantage
58
Shivam Pharma Chemicals
Tel
--
Fax
--
Email
info@shivampharma.com
Country
India
ProdList
656
Advantage
58
ChemOrbit International
Tel
--
Fax
--
Email
2014@gmail.com
Country
India
ProdList
264
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Meru Chem Pvt. Ltd.
Tel
--
Fax
--
Email
meruchempltd@gmail.com
Country
India
ProdList
174
Advantage
58
Anand Agencies
Tel
--
Fax
--
Email
en@gmail.com
Country
India
ProdList
2332
Advantage
58
Manav Bio -Chem Impex Pvt Ltd
Tel
--
Fax
--
Email
cheminquiry@gmail.com
Country
India
ProdList
204
Advantage
58
Pluto International
Tel
--
Fax
--
Country
India
ProdList
57
Advantage
58
Avra Synthesis Pvt Ltd
Tel
--
Fax
--
Email
info@avrasynthesis.com
Country
India
ProdList
1603
Advantage
30
Spectrochem Private Limited
Tel
--
Fax
--
Country
India
ProdList
1055
Advantage
58
G.c.intl
Tel
--
Fax
--
Country
India
ProdList
105
Advantage
58
Sriven Pharma
Tel
--
Fax
--
Country
India
ProdList
4
Advantage
58
More
Less

View Lastest Price from Cyclopropylamine manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Cyclopropylamine 765-30-0
Price
US $10.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
10 ton
Release date
2024-08-23
Wuhan Xinhao Biotechnology Co., Ltd
Product
Cyclopropylamine 765-30-0
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2024-03-12
Changzhou Rokechem Technology Co., Ltd.
Product
Cyclopropylamine 765-30-0
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99%
Supply Ability
1-10000kgs
Release date
2023-09-11

765-30-0, CyclopropylamineRelated Search:

Tranylcypromine Isopropylamine Diisopropylamine (-)-2-[METHYLAMINO]-1-PHENYLPROPANE TRANS-2-PHENYLCYCLOPROPYL ISOCYANATE D/L-AMPHETAMINE HYDROCHLORIDE Ciprofloxacin Rolicyprine Lorbamate Cyromazine CYCLOPROPYL ISOTHIOCYANATE 1-Aminocyclopropanecarboxylic acid 1-Aminocyclopropane-1-carboxylic acid hydrochloride Methyl 1-aminocyclopropanecarboxylate hydrochloride 1-(Cbz-amino)cyclopropanecarboxylic acid Tranylcypromine Hemisulfate tranylcypromine 1-BOC-3-AMINOPIPERIDINE

  • Cyclopropanamine
  • CYCLOPROPYLAMINE
  • AURORA KA-2551
  • AKOS BBS-00003593
  • AMINOCYCLOPROPANE
  • AMINOTRIMETHYLENE
  • Cyloprolylamine
  • Cyclopropyl amine(CPA)
  • Cydopropylamine
  • Cyclopropylamine,98%
  • Cylopropylamine
  • Cyclopropylamine 98%
  • CYCLOPROPYLAMINE W/O STABILIZING AGENT
  • CYCLOPROPYLAMINE W/STABILIZING AGENT
  • Cyclopropylamine ,99%
  • 1-Cyclopropanamine
  • Cyclopropylamine,Aminocyclopropane
  • CyclopropylaMine, 98% 25ML
  • CyclopropylaMine, 99% 10ML
  • CyclopropylaMine, 99% 50ML
  • CYCLOPROPYLAMINE FOR SYNTHESIS
  • CyclopropylaMine, 97+%
  • Ring propylaMine
  • Moxifloxacin Impurity 43
  • Cyclopropylamine &gt
  • 1-cyclopropyl-6,7-difluoro-8-methoxyquinolin-4(1H)-one
  • Cyclopropylamine (6CI, 7CI, 8CI)
  • Cyclopropylamine 98% For Synthesis
  • 765-30-0
  • 65-30-0
  • C3H7N
  • C3H5NH2
  • Simple 3-Membered Ring Compounds
  • Cyclopropanes
  • AMINE
  • Building Blocks
  • Amines
  • C2 to C6
  • Organic Building Blocks
  • Nitrogen Compounds
  • Pharmaceutical Intermediates
  • Cyclopropanes
  • Simple 3-Membered Ring Compounds