Description Reference
ChemicalBook > CAS DataBase List > 1,2,3,4-TETRAHYDROISOQUINOLINE

1,2,3,4-TETRAHYDROISOQUINOLINE

Description Reference
Product Name
1,2,3,4-TETRAHYDROISOQUINOLINE
CAS No.
91-21-4
Chemical Name
1,2,3,4-TETRAHYDROISOQUINOLINE
Synonyms
AKOS BB-9293;LABOTEST-BB LTBB000776;Tetrahydroisoquinoline;1,2,3,4-TetrahydroisoquinoL;3,4-Dihydro-1H-isoquinoline.;1,2,3,4-TETRAHYDROISOQUINOLINE;1,2,3,4-Tetrahydroisochinoline;1,2,3,4-tetrahydro-isoquinolin;1,2,3,4-Tetrahydro-2-isoquinoline;Isoquinoline, 1,2,3,4-tetrahydro-
CBNumber
CB5126507
Molecular Formula
C9H11N
Formula Weight
133.19
MOL File
91-21-4.mol
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1,2,3,4-TETRAHYDROISOQUINOLINE Property

Melting point:
−30 °C(lit.)
Boiling point:
232-233 °C(lit.)
Density 
1.064 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.568(lit.)
Flash point:
210 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
20g/l
pka
9.66±0.20(Predicted)
form 
Liquid
color 
Clear yellow to brown
Water Solubility 
Soluble in water at 20°C 20g/L.
BRN 
116156
InChIKey
UWYZHKAOTLEWKK-UHFFFAOYSA-N
CAS DataBase Reference
91-21-4(CAS DataBase Reference)
EPA Substance Registry System
Isoquinoline, 1,2,3,4-tetrahydro- (91-21-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
NX4900000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T13005
Product name
1,2,3,4-Tetrahydroisoquinoline
Purity
95%
Packaging
25g
Price
$42.6
Updated
2021/03/22
Sigma-Aldrich
Product number
T13005
Product name
1,2,3,4-Tetrahydroisoquinoline
Purity
95%
Packaging
100g
Price
$126
Updated
2021/03/22
TCI Chemical
Product number
T1676
Product name
1,2,3,4-Tetrahydroisoquinoline
Purity
>95.0%(GC)
Packaging
25g
Price
$40
Updated
2021/03/22
TCI Chemical
Product number
T1676
Product name
1,2,3,4-Tetrahydroisoquinoline
Purity
>95.0%(GC)
Packaging
100g
Price
$102
Updated
2021/03/22
Alfa Aesar
Product number
L08143
Product name
1,2,3,4-Tetrahydroisoquinoline, 97%
Packaging
100g
Price
$114
Updated
2021/03/22
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1,2,3,4-TETRAHYDROISOQUINOLINE Chemical Properties,Usage,Production

Description

1, 2, 3, 4-TETRAHYDROISOQUINOLINE belongs to tetrahydroisoquinoline compound, which is encountered in a number of drugs, tubocurarine, one of the quaternary ammonium muscle relaxants1-3. It is used as a reagent in the preparation of4-(1, 2, 4-oxadiazol-5-yl) piperidine-1-carboxamides as antiproliferative tubulin inhibitors1. It can be used for the synthesis of 1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid (Tic), which has strong applications in peptides and peptidomimetics design and discovery2. 1, 2, 3, 4-tetrahydroisoquinoline has been made into some derivatives with potential for prevention of parkinsonism4, cancer treatment5 and acting as Anticonvulsant Agents6.

Reference

  1. https://www.alfa.com/en/catalog/L08143/
  2. https://www.ncbi.nlm.nih.gov/pubmed/21235510
  3. https://en.wikipedia.org/wiki/Tetrahydroisoquinoline
  4. Okuda, K, Y. Kotake, and S. Ohta. "Parkinsonism-preventing activity of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline derivatives in C57BL mouse in vivo. Biological & Pharmaceutical Bulletin 29.7(2006):1401-1403.
  5. Luca, Laura De, et al. "3D Pharmacophore Models for 1, 2, 3, 4‐Tetrahydroisoquinoline Derivatives Acting as Anticonvulsant Agents." Archiv Der Pharmazie 339.7(2006):388-400.
  6. Hatano, H, et al. "Tumor-specific cytotoxic activity of 1, 2, 3, 4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines."Anticancer Research 29.8(2009):3079-3086.

Chemical Properties

clear yellow to brown liquid

Synthesis Reference(s)

The Journal of Organic Chemistry, 40, p. 1191, 1975 DOI: 10.1021/jo00897a001
Tetrahedron Letters, 26, p. 4633, 1985 DOI: 10.1016/S0040-4039(00)98771-9

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1,2,3,4-TETRAHYDROISOQUINOLINE Suppliers

Shanghai Co-magnate Industrial Co., Ltd.
Tel
021-62165619-
Fax
021-62165619
Email
xumin@co-magnate.com
Country
China
ProdList
128
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55
Shanghai PharmaTech New Drug Development Co., Ltd
Tel
Email
3553462045@qq.com
Country
China
ProdList
68
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
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China
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96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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21-61259100-
Fax
86-21-61259102
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sh@meryer.com
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China
ProdList
40264
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62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
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3bsc@sina.com
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China
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15877
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Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
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Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
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China
ProdList
3392
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Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43503
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61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18227
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View Lastest Price from 1,2,3,4-TETRAHYDROISOQUINOLINE manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
1,2,3,4-TETRAHYDROISOQUINOLINE 91-21-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-13
Hebei Xibaijie Biotechnology Co., Ltd.
Product
China 1,2,3,4-TETRAHYDROISOQUINOLINE 91-21-4
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500 Ton/Tons per Month
Release date
2020-07-14
Hebei Xibaijie Biotechnology Co., Ltd.
Product
New 1,2,3,4-TETRAHYDROISOQUINOLINE 91-21-4
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500 Ton/Tons per Month
Release date
2020-07-14

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