6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

Product Name: 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
CAS No.: 164148-92-9
Chemical Name: 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
Synonyms: TERT-BUTYL 6-AMINO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;164148-92-9;6-AMINO-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE;2-Boc-6-amino-1,2,3,4-tetrahydroisoquinoline;6-Amino-2-Boc-1,2,3,4-tetrahydro-isoquinoline;6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline, >=98%;REF DUPL: 6-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinoline;TERT-BUTYL 6-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLATE;tert-butyl 6-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
CBNumber: CB4419398
Molecular Formula: C14H20N2O2
Formula Weight: 248.32
MOL File: 164148-92-9.mol

More

Less

6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Property

Boiling point:: 394.7±42.0 °C(Predicted)
Density: 1.145±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 4.35±0.20(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C14H20N2O2/c1-14(2,3)18-13(17)16-7-6-10-8-12(15)5-4-11(10)9-16/h4-5,8H,6-7,9,15H2,1-3H3
InChIKey: OLOIFCYZWOTWRO-UHFFFAOYSA-N
SMILES: C1C2=C(C=C(N)C=C2)CCN1C(OC(C)(C)C)=O
CAS DataBase Reference: 164148-92-9(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn,N
Risk Statements: 36/37/38-50-22
Safety Statements: 26-36/37/39-61
RIDADR: UN2811
HS Code: 2922390090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: A632955
Product name: 6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline
Packaging: 1g
Price: $275
Updated: 2021/12/16

Matrix Scientific

Product number: 073247
Product name: 2-Boc-6-Amino-1,2,3,4-tetrahydroisoquinoline
Purity: 95+%
Packaging: 5g
Price: $207
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA41996
Product name: 6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline
Packaging: 2g
Price: $250
Updated: 2021/12/16

Ark Pharm

Product number: P000060244
Product name: tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 98%
Packaging: 1g
Price: $55
Updated: 2021/12/16

Ark Pharm

Product number: P000060244
Product name: tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 98%
Packaging: 5g
Price: $166
Updated: 2021/12/16

More

Less

6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Chemical Properties,Usage,Production

Uses

6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline is used as a reagent in the preparation of potent and long acting oral factor Xa inhibitors.

Synthesis

1154424-63-1

164148-92-9

General procedure for the synthesis of 6-amino-2-N-BOC-1,2,3,4-tetrahydro-isoquinoline from compound (CAS:1154424-63-1): ammonium formate (3.68 g, 57.5 mmol) was added to a stirred ethanol (EtOH, 25 mL) solution of compound 2 (2.2 g, 5.75 mmol) and the reaction mixture was heated to refluxed for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a diatomaceous earth bed to remove insoluble impurities. Subsequently, the diatomaceous earth bed and the filtrate were combined and concentrated under reduced pressure to afford compound 3 (1.3 g, 91% yield) as a dark brown oil, which could be used in subsequent reactions without further purification.

References

[1] Patent: WO2009/158571, 2009, A1. Location in patent: Page/Page column 165; 167; 168

6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Preparation Products And Raw materials

Raw materials

Ethyl formate Di-tert-butyl dicarbonate Potassium carbonate 1,2,3,4-TETRAHYDROISOQUINOLINE Paraformaldehyde Sodium borohydride Triethylamine Palladium 1,4-Dioxane Polyphosphoric acid Trifluoroacetic anhydride 2-(4-Bromophenyl)ethylamine Ethyl acetate Sodium bicarbonate Dichloromethane Acetic acid Sodium hydroxide Ammonium acetate Isopropyl alcohol Sulfuric acid Ammonia Potassium nitrate

Preparation Products

More

Less

6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Suppliers

China 118 Germany 1 India 1 Ukraine 1 United Kingdom 8 United States 21 Global 150

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

Kangyue Huilan Pharmaceutical Technology Co., Ltd

Tel: 028-81092800 17323275954
Email: 2567869566@qq.com
Country: China
ProdList: 492
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chembon Pharmaceutical Co., Ltd.

Tel: 028-84252981
Fax: +86-28-84252965
Email: sales@chembon.com.cn
Country: China
ProdList: 850
Advantage: 64

Shanghai Feibo Chemical Technology Co., Ltd

Tel: 021-58955608,2250286 15921236618
Email: blinkzeng@gmail.com
Country: China
ProdList: 522
Advantage: 62

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

More

Less

View Lastest Price from 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE manufacturers

Career Henan Chemical Co

Product: 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 164148-92-9
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

164148-92-9, 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINERelated Search:

N-CARBAMYL-L-GLUTAMIC ACID 3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester N-Acetyl-L-cysteine 5,6,7,8-TETRAHYDROISOQUINOLINE 1,2,3,4-TETRAHYDROISOQUINOLINE T-BUTYL 4-BROMOBUTYRATE [2-(3-AMINO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 6-AMINO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE tert-butyl 6-[(methylsulfonyl)amino]-3,4-dihydroisoquinoline-2(1H)-carboxylate

6-AMINO-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE

6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

6-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

TERT-BUTYL 6-AMINO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

2-Boc-6-amino-1,2,3,4-tetrahydroisoquinoline

REF DUPL: 6-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinoline

2(1H)-Isoquinolinecarboxylic acid, 6-amino-3,4-dihydro-, 1,1-dimethylethyl ester

tert-butyl6-amino-1,4,4a,8a-tetrahydroisoquinoline-2(3H)-carboxylate

6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline, >=98%

tert-butyl 6-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

6-Amino-2-Boc-1,2,3,4-tetrahydro-isoquinoline

TERT-BUTYL 6-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLATE

6-Amino-3,4-dihydro-1H-isoquinolin-2-carboxylic acid tert-butyl ester

164148-92-9

pharmacetical