T-BUTYL 4-BROMOBUTYRATE

Product Name: T-BUTYL 4-BROMOBUTYRATE
CAS No.: 110661-91-1
Chemical Name: T-BUTYL 4-BROMOBUTYRATE
Synonyms: Elagolix Impurity 12;Elagolix Impurity 32;ert-Butyl4-bromobutanoate;tert-Butyl4-bromobutanoate95%;tert-Butyl 4-bromobutanoate, tech;1,1-Dimethylethyl 4-bromobutanoate;4-Bromobutanoic acid tert-butyl ester;110661-91-1;Butanoic acid, 4-broMo-,1,1-diMethylethyl ester;tert-Butyl 4-bromobutanoate , tert-Butyl 4-bromobutanoate
CBNumber: CB91118864
Molecular Formula: C8H15BrO2
Formula Weight: 223.11
MOL File: 110661-91-1.mol

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T-BUTYL 4-BROMOBUTYRATE Property

Boiling point:: 225.9±23.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: soluble in Chloroform, Hexane
form: liquid
color: Colourless to light yellow

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Safety

Risk Statements: 34-36/37/38
Safety Statements: 22-26-36/37/39-45
RIDADR: 1760
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 29033990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B6167
Product name: tert-Butyl 4-Bromobutanoate
Purity: min. 97.0 %
Packaging: 5G
Price: $93
Updated: 2025/07/31

TCI Chemical

Product number: B6167
Product name: tert-Butyl 4-Bromobutanoate
Purity: min. 97.0 %
Packaging: 25G
Price: $369
Updated: 2025/07/31

TRC

Product number: B682040
Product name: t-Butyl4-Bromobutyrate
Packaging: 1g
Price: $130
Updated: 2021/12/16

Oakwood

Product number: 011598
Product name: t-Butyl 4-bromobutyrate
Packaging: 1g
Price: $20
Updated: 2021/12/16

Apolloscientific

Product number: OR11460
Product name: tert-Butyl4-bromobutanoate
Purity: 95%
Packaging: 1g
Price: $22
Updated: 2021/12/16

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T-BUTYL 4-BROMOBUTYRATE Chemical Properties,Usage,Production

Uses

t-Butyl 4-Bromobutyrate. is a potent CB1 receptor antagonist involved in the cannabinoid-1 receptor signalling process. Inhibition of this receptor has been demonstrated to inhibit feeding behaviors. Antiinflammatory.

Synthesis

2623-87-2

75-65-0

110661-91-1

The general procedure for the synthesis of tert-butyl 4-bromobutyrate from 4-bromobutyric acid and tert-butanol was as follows: 4-bromobutyric acid (2.57 g, 15.39 mmol, 1 eq.) was dissolved in dichloromethane (20 mL), magnesium sulfate (7.74 g, 64.30 mmol, 4.2 eq.), tert-butanol (5.70 g, 76.95 mmol, 5 eq.) and concentrated sulfuric acid (0.25 mL). The reaction mixture was stirred at room temperature for 2 days. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous sodium bicarbonate and the reaction mixture was extracted with dichloromethane. The organic layers were combined, washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by medium pressure silica gel column chromatography (eluent: n-hexane/ethyl acetate=50/50) to afford the target compound tert-butyl 4-bromobutyrate (1.17 g, 5.24 mmol, 47% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and 13C NMR (100 MHz, CDCl3): 1H NMR δ 1.27 (s, 9H), 1.91-1.98 (m, 2H), 2.22 (t, 2H, J=7.2Hz), 3.27 (t, 2H, J=6.5Hz); 13C NMR δ 27.9 , 28.0, 32.8, 33.7, 80.5, 171.7.

References

[1] Tetrahedron Asymmetry, 2004, vol. 15, # 8, p. 1247 - 1258
[2] ACS Combinatorial Science, 2016, vol. 18, # 12, p. 710 - 722
[3] Angewandte Chemie - International Edition, 2010, vol. 49, # 15, p. 2738 - 2742
[4] European Journal of Organic Chemistry, 2003, # 8, p. 1486 - 1493
[5] Patent: US2018/52109, 2018, A1. Location in patent: Paragraph 0156; 0157; 0158; 0159

T-BUTYL 4-BROMOBUTYRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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T-BUTYL 4-BROMOBUTYRATE Suppliers

Americas 1 Canada 1 China 137 Europe 1 India 4 Japan 1 United Kingdom 3 United States 9 Global 157

Hangzhou Aiken New Materials Co., Ltd

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Email: 1624352@qq.com
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Tetranov Biopharm

Tel: 13526569071
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Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
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Shanghai Hanhong Scientific Co.,Ltd.

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China DongFan Chemical Co.,LTD

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Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
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Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
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Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
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View Lastest Price from T-BUTYL 4-BROMOBUTYRATE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: T-BUTYL 4-BROMOBUTYRATE 110661-91-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-15

Career Henan Chemical Co

Product: T-BUTYL 4-BROMOBUTYRATE 110661-91-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-03

110661-91-1, T-BUTYL 4-BROMOBUTYRATE Related Search:

Carbamic acid, N-[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester 1-[(1R)-2-hydroxy-1-phenylethyl]pyrrolidin-2-one (R)-2-(Boc-aMino)-2-phenylethyl 4-Methylbenzenesulfonate 3-Bromo-2-fluoroanisole 1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA elagolix (R)-1,2-Diamino-1-phenylethane Elagolix Sodium impurity4 2,2'-difluoro-3,3'-dimethoxy-1,1'-biphenyl 5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione 3-[(2R)-2-Amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 4-Bromobutyl acetate Carbamic acid, N-[(1R)-2-[5-bromo-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester Carbamic acid, N-[(1R)-2-[5-(2-fluoro-3-hydroxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester 2,4(1H,3H)-Pyrimidinedione, 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluoro-3-hydroxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl- O-Demethyl elagolix sodium

Butanoic acid, 4-broMo-,1,1-diMethylethyl ester

tert-Butyl 4-bromobutanoate, tech

tert-Butyl4-bromobutanoate95%

4-Bromobutanoic acid tert-butyl ester

Elagolix Impurity 32

Elagolix Impurity 12

ert-Butyl4-bromobutanoate

1,1-Dimethylethyl 4-bromobutanoate

tert-Butyl 4-bromobutanoate , tert-Butyl 4-bromobutanoate

110661-91-1

Acids & Esters

Bromine Compounds