T-BUTYL 4-BROMOBUTYRATE
- Product Name
- T-BUTYL 4-BROMOBUTYRATE
- CAS No.
- 110661-91-1
- Chemical Name
- T-BUTYL 4-BROMOBUTYRATE
- Synonyms
- Elagolix Impurity 12;Elagolix Impurity 32;ert-Butyl4-bromobutanoate;tert-Butyl4-bromobutanoate95%;tert-Butyl 4-bromobutanoate, tech;1,1-Dimethylethyl 4-bromobutanoate;4-Bromobutanoic acid tert-butyl ester;110661-91-1;Butanoic acid, 4-broMo-,1,1-diMethylethyl ester;tert-Butyl 4-bromobutanoate , tert-Butyl 4-bromobutanoate
- CBNumber
- CB91118864
- Molecular Formula
- C8H15BrO2
- Formula Weight
- 223.11
- MOL File
- 110661-91-1.mol
T-BUTYL 4-BROMOBUTYRATE Property
- Boiling point:
- 225.9±23.0 °C(Predicted)
- Density
- 1.258±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- soluble in Chloroform, Hexane
- form
- liquid
- color
- Colourless to light yellow
Safety
- Risk Statements
- 34-36/37/38
- Safety Statements
- 22-26-36/37/39-45
- RIDADR
- 1760
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 29033990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B6167
- Product name
- tert-Butyl 4-Bromobutanoate
- Purity
- min. 97.0 %
- Packaging
- 5G
- Price
- $93
- Updated
- 2025/07/31
- Product number
- B6167
- Product name
- tert-Butyl 4-Bromobutanoate
- Purity
- min. 97.0 %
- Packaging
- 25G
- Price
- $369
- Updated
- 2025/07/31
- Product number
- B682040
- Product name
- t-Butyl4-Bromobutyrate
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FB140514
- Product name
- tert-Butyl 4-bromobutanoate
- Packaging
- 5G
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 113978
- Product name
- tert-Butyl 4-bromobutanoate
- Purity
- 97%
- Packaging
- 25g
- Price
- $168
- Updated
- 2021/12/16
T-BUTYL 4-BROMOBUTYRATE Chemical Properties,Usage,Production
Uses
t-Butyl 4-Bromobutyrate. is a potent CB1 receptor antagonist involved in the cannabinoid-1 receptor signalling process. Inhibition of this receptor has been demonstrated to inhibit feeding behaviors. Antiinflammatory.
Synthesis
2623-87-2
75-65-0
110661-91-1
The general procedure for the synthesis of tert-butyl 4-bromobutyrate from 4-bromobutyric acid and tert-butanol was as follows: 4-bromobutyric acid (2.57 g, 15.39 mmol, 1 eq.) was dissolved in dichloromethane (20 mL), magnesium sulfate (7.74 g, 64.30 mmol, 4.2 eq.), tert-butanol (5.70 g, 76.95 mmol, 5 eq.) and concentrated sulfuric acid (0.25 mL). The reaction mixture was stirred at room temperature for 2 days. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous sodium bicarbonate and the reaction mixture was extracted with dichloromethane. The organic layers were combined, washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by medium pressure silica gel column chromatography (eluent: n-hexane/ethyl acetate=50/50) to afford the target compound tert-butyl 4-bromobutyrate (1.17 g, 5.24 mmol, 47% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and 13C NMR (100 MHz, CDCl3): 1H NMR δ 1.27 (s, 9H), 1.91-1.98 (m, 2H), 2.22 (t, 2H, J=7.2Hz), 3.27 (t, 2H, J=6.5Hz); 13C NMR δ 27.9 , 28.0, 32.8, 33.7, 80.5, 171.7.
References
[1] Tetrahedron Asymmetry, 2004, vol. 15, # 8, p. 1247 - 1258
[2] ACS Combinatorial Science, 2016, vol. 18, # 12, p. 710 - 722
[3] Angewandte Chemie - International Edition, 2010, vol. 49, # 15, p. 2738 - 2742
[4] European Journal of Organic Chemistry, 2003, # 8, p. 1486 - 1493
[5] Patent: US2018/52109, 2018, A1. Location in patent: Paragraph 0156; 0157; 0158; 0159
T-BUTYL 4-BROMOBUTYRATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from T-BUTYL 4-BROMOBUTYRATE manufacturers
- Product
- T-BUTYL 4-BROMOBUTYRATE 110661-91-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-15
- Product
- T-BUTYL 4-BROMOBUTYRATE 110661-91-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03