H-DL-TIC-OH
- Product Name
- H-DL-TIC-OH
- CAS No.
- 67123-97-1
- Chemical Name
- H-DL-TIC-OH
- Synonyms
- DL-Tic-OH;NSC 14794;H-DL-TIC-OH;AKOS BB-6895;3-CARBOXY-1,2,3,4-TETRAHYDROISOQUINOLINE;1,2,3,4-Tetrahydroisoquinoline-3Carboxylic;DL-3-Carboxy-1,2,3,4-tetrahydroisoquinoline;rac 3-Carboxy-1,2,3,4-tetrahydroisoquinoline;1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;3-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro-
- CBNumber
- CB1349115
- Molecular Formula
- C10H11NO2
- Formula Weight
- 177.2
- MOL File
- 67123-97-1.mol
H-DL-TIC-OH Property
- Melting point:
- 358°C
- Boiling point:
- 372.0±42.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Sodium Hydroxide, Water
- form
- Solid
- pka
- 2.21±0.20(Predicted)
- color
- White
- CAS DataBase Reference
- 67123-97-1
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T4195
- Product name
- H-DL-Tic-OH
- Packaging
- 5G
- Price
- $99
- Updated
- 2025/07/31
- Product number
- T293750
- Product name
- rac1,2,3,4-Tetrahydroisoquinoline-3-carboxylicAcid
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- T293750
- Product name
- rac1,2,3,4-Tetrahydroisoquinoline-3-carboxylicAcid
- Packaging
- 10g
- Price
- $945
- Updated
- 2021/12/16
- Product number
- 13732
- Product name
- rac1,2,3,4-Tetrahydroisoquinoline-3-carboxylicAcid
- Packaging
- 5G
- Price
- $1640
- Updated
- 2021/12/16
- Product number
- CS-W004987
- Product name
- 1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacid
- Purity
- 99.74%
- Packaging
- 10g
- Price
- $55
- Updated
- 2021/12/16
H-DL-TIC-OH Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
rac 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (cas# 67123-97-1) is a compound useful in organic synthesis.
Synthesis
50-00-0
150-30-1
67123-97-1
D,L-phenylalanine (50 g, 3.03 mol) was used as raw material to prepare its suspension. Concentrated hydrochloric acid (325 mL) and 37% formaldehyde solution (110 mL) were added to the suspension under vigorous stirring and heated to a mild reflux condition and maintained for 30 min. Subsequently, additional formaldehyde (50 mL) and concentrated hydrochloric acid (110 mL) were added and the reaction continued to heat for 4 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was collected by filtration. The solid was washed with methanol (30 mL) and dried to afford the target compound 3-carboxy-1,2,3,4-tetrahydroisoquinoline in a yield of 64.09 g (98.9% yield) with a melting point of 295-298 °C (decomposition temperature >326 °C) (Literature reference: Julian PL, J. Chem. Soc. 1948, 70, 180-183) as an enantiomeric mixtures. Its NMR hydrogen spectrum (DMSO-d6) data are as follows: δ 3.10-3.18 (1H, m, CH), 3.28-3.34 (1H, m, CH), 4.27 (2H, s, CH2), 4.39 (1H, m, CH), 7.25-7.27 (4H, m, 4*ArH), 9.89 (1H, brs, exchangeable, NH) , 10.06 (1H, brs, exchangeable, OH). Mass spectral data: m/z 177.0 (M+H)+.
References
[1] Patent: US2009/117125, 2009, A1. Location in patent: Page/Page column 15
[2] Bulletin of the Chemical Society of Japan, 1991, vol. 64, # 12, p. 3729 - 3731
[3] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1325 - 1344
[4] Journal of the American Chemical Society, 1948, vol. 70, p. 180,182
[5] Journal of Organic Chemistry, 1951, vol. 16, p. 430
H-DL-TIC-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from H-DL-TIC-OH manufacturers
- Product
- H-DL-TIC-OH 67123-97-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- H-DL-TIC-OH 67123-97-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- H-DL-TIC-OH 67123-97-1
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- G/KG/T
- Release date
- 2019-12-23