L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

Description

Product Name: L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
CAS No.: 74163-81-8
Chemical Name: L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Synonyms: Tic-OH;(S)-TIC;L-TIC HCL;L-1,2,3,4-Tetrahydro;Icatibant Impurity 14;Quinapril Bicyclic Acid;Quinapril EP Impurity A;(S)-1,2,3,4-Tetrahydro-3-isoquinoL;Quinapril Hydrochloride Impurity A;(3S)-1,2,3,4-Tetrahydroisoquinoline
CBNumber: CB0197924
Molecular Formula: C10H11NO2
Formula Weight: 177.2
MOL File: 74163-81-8.mol

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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Property

Melting point:: >300 °C(lit.)
alpha: -157.4 º (24 ºC)
Boiling point:: 309.12°C (rough estimate)
Density: 1.1607 (rough estimate)
refractive index: -166 ° (C=1, 1mol/L NaOH)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: soluble in Hot Water, Basic Water
pka: 2.21±0.20(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: [α]20/D 168°, c = 1.8 in 1.4 M NaOH
BRN: 4842199
InChIKey: BWKMGYQJPOAASG-VIFPVBQESA-N
CAS DataBase Reference: 74163-81-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 421626
Product name: (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid
Purity: 97%
Packaging: 5g
Price: $25
Updated: 2024/03/01

TCI Chemical

Product number: T1515
Product name: (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $72
Updated: 2024/03/01

TCI Chemical

Product number: T1515
Product name: (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $208
Updated: 2024/03/01

Alfa Aesar

Product number: L14422
Product name: (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, 97%
Packaging: 1g
Price: $23.65
Updated: 2024/03/01

Alfa Aesar

Product number: L14422
Product name: (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, 97%
Packaging: 5g
Price: $65.65
Updated: 2024/03/01

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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Chemical Properties,Usage,Production

Description

(S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a quinoline derivative, which is used as an intermediate in the synthesis of quinapril. Quinapril, a product developed by Pfizer, was approved by the US FDA in 1991 for the treatment of hypertension, congestive heart failure and angioedema.

Chemical Properties

white to light yellow crystal powde

Uses

(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Quinapril EP Impurity A) is a Quinapril intermediate.

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Suppliers

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View Lastest Price from L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid manufacturers

Hebei Duling International Trade Co. LTD

Product: L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 74163-81-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000tons
Release date: 2022-10-16

Henan Aochuang Chemical Co.,Ltd.

Product: L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 74163-81-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 74163-81-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

74163-81-8, L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acidRelated Search:

Tetrahydrofuran 1,2,3,4-Tetrahydroquinoline 1,2,3,4-TETRAHYDROISOQUINOLINE Tetramethylammonium hydroxide pentahydrate Isoquinoline Potassium hydrogen phthalate Isoquinoline-1-carboxylic acid 5,6,7,8-TETRAHYDROISOQUINOLINE cis-1,2,3,6-Tetrahydrophthalic anhydride 2-Tetrahydrofuroic acid H-TLE-OTBU HCL H-Tic-OMe·HCl L-tert-Leucine methyl ester hydrochloride H-Tic-OtBu·HCl (S)-6,7-Dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride Quinapril hydrochloride Moexipril (S)-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE,L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE

(S)-TIC

(S)-N-tert-1,2,3,4-tetrahydroisoquinoline -3-carboxamide

L-1,2,3,4-Tetrahydro

4-Tetrahydro-3-Isoquinolinecarboxylic acid

[S]-1,2,3,4-Tetrahydro-3-Isoquinolingcarboxylic Acid

(S)-1, 2, 3, 4-tetrahydro-3-isoquinolinecarboxylic acid (for Quinapril)

L-1,2,3,4-Tetrahydroisoquinoline-3-CarboxylicAcid98%

(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYLESTHER

(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLICACIDHYDROCHLORIDE

L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC

(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxlicacid

(S)-1,2,3,4-Tetrahydro-3-isoquinoline-carboxylic aci

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

1,2,3,4-Tetrahydroisoquinoline-3-carboxxylic acid

(S)-1,2,3,4-TERTRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID

(3S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECA

(S)-1,2,3,4-Tetrahydro-3-isoquinoline-carboxylic acid hydrochloride, 95+%

(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacid,97%

(<i>S</i>)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

Quinapril Bicyclic Acid

(S)-1,2,3,4-TETRAHYDO-3-ISOQUINOLINECARBOXYLIC ACID HCL

(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HCL SALT

(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HYDROCHLORIDE

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HCL

S-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE

(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid≥ 98% (HPLC)

Tic-OH

(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid,99%e.e.

(3S)-1,2,3,4-Tetrahydro-3-isoquinolinecarbocylic acid for synthesis

L-TIC HCL

L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE

3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-,(3S)-

Quinapril EP Impurity A

Quinapril Impurity 1（Quinapril EP Impurity A）

(3S)-1,2,3,4-Tetrahydroisoquinoline

(S)-1,2,3,4-Tetrahydro-3-isoquinoL

[S]-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINGCARBOXYLIC ACID (CAS:74163-81-8)

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid USP/EP/BP

(S)-(-) 1,2,3, 4-Tetrahydroisoquinoline -3-Carboxylic Acid pure, 98%

(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

Quinapril Hydrochloride EP Impurity A

(-)-1,2,3,4-Tetrahydro-isoquinolin-3-carboxylic acid

Quinapril Hydrochloride Impurity A

Icatibant Impurity 14

74163-81-8

Others

Peptide Synthesis

Unnatural Amino Acid Derivatives

Specialty Synthesis

Carboxylic Acids

(intermediate of quinapril)

Carboxylic Acids

Quinolines, Isoquinolines & Quinoxalines

chiral

Amino Acids

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals