2-PhenylethylaMine Property

Melting point:

-60 °C

Boiling point:

197-200 °C (lit.)

Density 

0.962 g/mL at 20 °C (lit.)

vapor density 

4.18 (vs air)

vapor pressure 

0.4 hPa (20 °C)

FEMA 

3220 | PHENETHYLAMINE

refractive index 

n20/D 1.533(lit.)

Flash point:

195 °F

storage temp. 

Store below +30°C.

solubility 

alcohol: freely soluble(lit.)

form 

liquid

pka

9.84(at 25℃)

color 

clear, colorless

PH

11.5 (4.3g/l, H2O, 20℃)

Odor

fishy odor

PH Range

11.5 at 4.3 g/l at 20 °C

Odor Type

fishy

explosive limit

1.0-5.5%(V)

Water Solubility 

SOLUBLE

Sensitive 

Air Sensitive

Merck 

14,6026

JECFA Number

1589

BRN 

507488

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents, strong acids.

InChIKey

BHHGXPLMPWCGHP-UHFFFAOYSA-N

LogP

1.46

CAS DataBase Reference

64-04-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzeneethanamine(64-04-0)

EPA Substance Registry System

Phenethylamine (64-04-0)

Safety

Hazard Codes 

C

Risk Statements 

22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2922 8/PG 2

WGK Germany 

1

RTECS 

SG8750000

F 

9-23

Autoignition Temperature

425 °C

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29214980

Hazardous Substances Data

64-04-0(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 300 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-PhenylethylaMine Chemical Properties,Usage,Production

Chemical Properties

colourless or slightly yellow liquid with

Chemical Properties

Phenethylamine has a fish odor.

Occurrence

Reported found in the oil of bitter almonds. Also found in grapes, cabbage, kale, carrots, blue and provolone cheese, fatty fish, beer, sherry, grape wines, cocoa, cauliflower, beetroot, radish, rhubarb, sake and dried bonito.

Uses

Phenethylamine is used in manufacturing anti-depression agents and anti diabetic drugs. It is also used as the goodds for drug jiangtangling intermediate, also used for other organic synthesis.

Preparation

By reduction of benzyl cyanide with sodium metal in alcohol or with Raney-Ni.

Definition

ChEBI: A phenylethylamine having the phenyl substituent at the 2-position.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 34, p. 3905, 1986 DOI: 10.1248/cpb.34.3905
Journal of the American Chemical Society, 94, p. 6561, 1972 DOI: 10.1021/ja00773a060
Tetrahedron Letters, 21, p. 1719, 1980 DOI: 10.1016/S0040-4039(00)77819-1

General Description

Phenethylamine, a new stimulant designer drug, was analyzed by the liquid chromatography high-resolution mass spectrometry quadrupole-time-of-flight (LC-HRMS-QTOF) method.

Safety Profile

Poison by intraperitoneal, subcutaneous, intracervical, and intravenous routes. Moderately toxic by ingestion. A strong base. A skin irritant and possible sensitizer. When heated to decomposition it emits toxic fumes of NOx. See also AMINES

Purification Methods

Distil the amine from CaH2, under reduced pressure, just before use. [Beilstein 12 H 1096, 12 IV 2453.]