ChemicalBook > CAS DataBase List > 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Product Name
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No.
2328-12-3
Chemical Name
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
Synonyms
7-DiMethoxy-1;TIMTEC-BB SBB003285;LABOTEST-BB LT00453025;HeliaMine Hydrochloride;4-tetrahydroisoquinoline hydrochloride;6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoL;6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolineHCl;isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-;6,7-Dimethoxy-1,2,3,4-tetrahydroisochinoline*HCl;6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline,chloride
CBNumber
CB0306261
Molecular Formula
C11H16ClNO2
Formula Weight
229.7
MOL File
2328-12-3.mol
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6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Property

Melting point:
260-265 °C(lit.)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble25mg/mL, clear, colorless (1N NaOH in methanol)
form 
Shiny Flakes or Crystalline Powder
color 
White to slightly beige
Water Solubility 
soluble 25mg/mL, clear, colorless (1N NaOH in methanol)
BRN 
3634126
InChI
InChI=1S/C11H15NO2.ClH/c1-13-10-5-8-3-4-12-7-9(8)6-11(10)14-2;/h5-6,12H,3-4,7H2,1-2H3;1H
InChIKey
SHOWAGCIRTUYNA-UHFFFAOYSA-N
SMILES
C12CCNCC=1C=C(OC)C(OC)=C2.Cl
CAS DataBase Reference
2328-12-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
NX5017980
HazardClass 
IRRITANT
HS Code 
29334900
Toxicity
mouse,LD50,intraperitoneal,272mg/kg (272mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Yakugaku Zasshi. Journal of Pharmacy. Vol. 88, Pg. 1197, 1968.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
291919
Product name
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
Purity
97%
Packaging
5g
Price
$23
Updated
2023/06/20
Sigma-Aldrich
Product number
291919
Product name
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
Purity
97%
Packaging
25g
Price
$45.4
Updated
2023/01/07
TCI Chemical
Product number
D2472
Product name
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$35
Updated
2025/07/31
TCI Chemical
Product number
D2472
Product name
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$88
Updated
2025/07/31
TRC
Product number
H235090
Product name
HeliamineHydrochloride
Packaging
100g
Price
$475
Updated
2021/12/16
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6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to slightly beige shiny flakes or

Uses

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride has been used as starting material for the synthesis of more complex isoquinolines and quinolizidines.

Definition

ChEBI: 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is a member of isoquinolines.

General Description

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is also referred as heliamine. It is an alkaloid isolated from mexican cereoid, Backebergia militaris.

Synthesis

50-00-0

120-20-7

2328-12-3

In a 250 mL single neck flask, 3,4-dimethoxyphenethylamine (18.1 g, 100 mmol), paraformaldehyde (3.6 g, 120 mmol) and anhydrous ethanol (30 mL) were added sequentially. Upon completion of the reaction, the mixture was cooled to room temperature and white crystals were collected by filtration to yield 14.2 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride in 61.8% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 20, p. 5285 - 5289
[2] Patent: CN107573325, 2018, A. Location in patent: Paragraph 0109; 0110; 0111
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 9, p. 2420 - 2427
[4] Pharmazie, 1990, vol. 45, # 6, p. 408 - 410
[5] Journal of the American Chemical Society, 1934, vol. 56, p. 1769

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Suppliers

Americas 1 Canada 1 China 145 Europe 1 Germany 7 India 4 Japan 3 South Korea 1 Switzerland 1 Ukraine 3 United Kingdom 8 United States 23 Global 198
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View Lastest Price from 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride manufacturers

Shanghai UCHEM Inc.
Product
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 2328-12-3
Price
US $15.00-368.00/g
Min. Order
25g
Purity
0.98
Supply Ability
25kg
Release date
2023-12-22
Zhuozhou Wenxi import and Export Co., Ltd
Product
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 2328-12-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride 2328-12-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

2328-12-3, 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochlorideRelated Search:

Diphenyldimethoxysilane Dimethylamine hydrochloride Dimethyldimethoxysilane Isoquinoline Topotecan hydrochloride 1,1-Dimethoxyethane Dimethoxymethane D-TUBOCURARINE CHLORIDE BOLDINE DIMETHYL ETHER TETRAHYDROPALMATINE HYDROCHLORIDE Emetine OXYACANTHINE HYDROCHLORIDE BERBAMINE DIHYDROCHLORIDE Emetine dihydrochloride ISOCORYDINE HYDROCHLORIDE 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 1-BENZYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 5,6,7,8-TETRAHYDROISOQUINOLINE

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