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Tetrahydropapaverine hydrochloride

Product Name
Tetrahydropapaverine hydrochloride
CAS No.
6429-04-5
Chemical Name
Tetrahydropapaverine hydrochloride
Synonyms
TETRAHYDROALKALI HYDROCHLORIDE;TETRAHYDROPAPAVERINE HCL;Norlaudanosine Hydrochloride;1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride;Nsc118072;Norlaudanosine HCl;NorlaudanosineHydrochloride>DL-NORLAUDANOSINE HYDROCHLORIDE;AtracuriuM Besylate intermediate;rac-Nor Laudanosine Hydrochloride
CBNumber
CB1501216
Molecular Formula
C20H25NO4.HCl
Formula Weight
379.8814
MOL File
6429-04-5.mol
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Tetrahydropapaverine hydrochloride Property

Melting point:
216.0 to 220.0 °C
storage temp. 
Sealed in dry,2-8°C
Water Solubility 
Soluble in water
solubility 
Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
form 
powder to crystal
color 
White to Almost white
InChI
InChI=1S/C20H25NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-6,10-12,16,21H,7-9H2,1-4H3;1H
InChIKey
VMPLLPIDRGXFTQ-UHFFFAOYSA-N
SMILES
C12C=C(C(OC)=CC=1CCNC2CC1=CC=C(OC)C(OC)=C1)OC.Cl
CAS DataBase Reference
6429-04-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xn
Risk Statements 
22
Safety Statements 
36
RTECS 
NX5070700
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S426016
Product name
DL-NORLAUDANOSINE HYDROCHLORIDE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$185
Updated
2025/07/31
Sigma-Aldrich
Product number
S426016
Product name
DL-NORLAUDANOSINE HYDROCHLORIDE
Purity
AldrichCPR
Packaging
50MG
Price
$179
Updated
2024/03/01
TCI Chemical
Product number
N0918
Product name
Norlaudanosine Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
N0918
Product name
Norlaudanosine Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$165
Updated
2025/07/31
Usbiological
Product number
289841
Product name
Tetrahydropapaverine HCl
Packaging
5g
Price
$340
Updated
2021/12/16
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Tetrahydropapaverine hydrochloride Chemical Properties,Usage,Production

Uses

Tetrahydropapaverine hydrochloride is an organic amine compound that can be used as atracuramide intermediate.

Biological Activity

Tetrahydropapaverine (Norlaudanosine), a TIQs, is an analogue of Salsolinol and Tetrahydropapaveroline, and has neurotoxic effects on dopamine neurons.

Synthesis

5884-22-0

6429-04-5

Crude 3,4-dihydroisoquinoline hydrochloride 12 (6.48 g) was suspended in methanol (50 mL) under argon protection and cooled to 0 °C. Sodium borohydride (0.8 g, 21 mmol) was slowly added to this suspension. The reaction mixture was stirred at room temperature for 10 minutes and then concentrated. Subsequently, brine (16 mL) and acetonitrile (30 mL) were added to the concentrate and the mixture was then partitioned between ethyl acetate (30 mL) and water (30 mL). The aqueous layer was extracted twice with a solvent mixture of ethyl acetate-acetonitrile (30 mL, 1:1). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated to give a yellow oil. This oily substance was dissolved in methanol (10 mL), 5% hydrochloric acid solution in methanol (20 mL) was added and concentrated again. The residue was crystallized by the addition of ether, and the solid was collected by filtration and washed with ether to give finally 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (6-HCl, 4.67 g, 89% yield, after a 3-step reaction) as a white solid with a melting point of 211-215 °C. The 1H NMR (DMSO-d6) data were as follows: δ 2.91 (1H, m), 3.16-3.24 (3H, m), 3.36 (1H, m), 3.56 (1H, m), 3.60 (3H, s), 3.80 (3H, s), 3.85 (6H, s), 4.73 (1H, m), 6.17 (1H, s), 6.58 ( 1H, s), 6.72 (1H, d, J = 8.0 Hz), 6.77-6.79 (2H, m), 9.77 (1H, br s), 10.35 (1H, br s). The 1H NMR (D2O) data were as follows: δ 3.01-3.05 (2H, m), 3.16-3.29 (2H, m), 3.41 (1H, m), 3.53 (1H, m), 3.60 (3H, s), 3.72 (3H, s), 3.83 (6H, s), 4.73 (1H, m), 6.36 (1H, s), 6.73 ( 1H, s), 6.83-6.89 (2H, m), 7.00 (1H, m).

References

[1] Heterocycles, 2014, vol. 8, # 2, p. 1311 - 1321

Tetrahydropapaverine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Tetrahydropapaverine hydrochloride Suppliers

Americas 1 Canada 1 China 255 Europe 1 Germany 1 India 9 Japan 1 United Kingdom 4 United States 24 Global 297
Jin Hesheng New Material Technology (Shandong) Co., LTD
Tel
17660279964 17660279964
Email
17660279964@139.com
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China
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Shandong Shenghe Pharmaceutical Technology Co. LTD
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13585296001
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haizaofu@163.com
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China
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Gansu Songsheng Pharmaceutical Co. , Ltd.
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13705130158
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sales@unitechemical.com
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China
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Lianyungang Shenghe Biotechnology Co., Ltd.
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13585296001 13585296001
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haizaofu@163.com
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China
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Jinan Chengquan Chemical Co., Ltd
Tel
13616405505
Email
zhulinsun1@126.com
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China
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Nanjing Yiyuan
Tel
18915107665 18061915908
Email
wwwang2011@163.com
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China
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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market03@meryer.com
Country
China
ProdList
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
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24529
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
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View Lastest Price from Tetrahydropapaverine hydrochloride manufacturers

Chongqing Soarwin Technology Co., Ltd
Product
Tetrahydropapaverine hydrochloride 6429-04-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
20 tons
Release date
2025-04-11
Shaanxi Dideu New Materials Co. Ltd
Product
Tetrahydropapaverine hydrochloride 6429-04-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-29
Shaanxi Dideu Medichem Co. Ltd
Product
Tetrahydropapaverine hydrochloride 6429-04-5
Price
US $0.10/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
1000Tons
Release date
2024-07-05

6429-04-5, Tetrahydropapaverine hydrochlorideRelated Search:

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  • 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDETETRAHYDROPAPAVERINE HYDROCHLORIDE
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  • Isoquinoline,1-[(3,4-diMethoxyphenyl)Methyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-,hydrochloride (1:1)
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  • AtracuriuM Besylate intermediate
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  • Tetrahydropapaverine (hydrochloride) (Papaverine Impurity)
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  • 6429-04-5
  • 6429-4-5
  • 6249-04-5
  • 164298-04-5
  • 64929-04-5
  • C20H25NO4HCl
  • C20H25NO4ClH
  • C20H25NO4HCI
  • Inhibitors