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Papaverine hydrochloride

Product Name
Papaverine hydrochloride
CAS No.
61-25-6
Chemical Name
Papaverine hydrochloride
Synonyms
PAPAVERINE HCL;paph;dipav;BOC-azide;1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE HYDROCHLORIDE;lapav;vasal;dynovas;optenyl;pameion
CBNumber
CB7689772
Molecular Formula
C20H22ClNO4
Formula Weight
375.85
MOL File
61-25-6.mol
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Papaverine hydrochloride Property

Melting point:
226°C (dec.)
storage temp. 
Amber Vial, Refrigerator
solubility 
H2O: 25 mg/mL
form 
powder
color 
white
PH
pH (20g/l, 25℃) : 3.0~4.0
Water Solubility 
freely soluble
Sensitive 
Light Sensitive
Merck 
14,7019
BRN 
3921435
Stability:
Stable, but may be light sensitive.
CAS DataBase Reference
61-25-6(CAS DataBase Reference)
EPA Substance Registry System
Papaverine hydrochloride (61-25-6)
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Safety

Hazard Codes 
Xn,C,F
Risk Statements 
22-34-11
Safety Statements 
22-45-36/37/39-26-16
RIDADR 
UN 1544 6.1/PG 3
WGK Germany 
1
RTECS 
NW8575000
8
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29391900
Toxicity
LD50 in mice, rats (mg/kg): 27.5, 20 i.v.; 150, 370 s.c. (Levis)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P3510
Product name
Papaverine hydrochloride
Purity
powder
Packaging
5g
Price
$51.7
Updated
2024/03/01
Sigma-Aldrich
Product number
1496008
Product name
Papaverine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Alfa Aesar
Product number
B25412
Product name
Papaverine hydrochloride, 99%
Packaging
5g
Price
$47.3
Updated
2024/03/01
Alfa Aesar
Product number
B25412
Product name
Papaverine hydrochloride, 99%
Packaging
25g
Price
$125
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1182
Product name
Papaverine hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$180
Updated
2024/03/01
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Papaverine hydrochloride Chemical Properties,Usage,Production

Description

Papaverine Hydrochloride, USP, is the hydrochloride of an alkaloid obtained from opium or prepared synthetically. It belongs to the benzylisoquinoline group of alkaloids. It does not contain a phenanthrene group as do morphine and codeine.
Papaverine Hydrochloride, USP, is 6,7-dimethoxy-1-veratrylisoquinoline hydrochloride and contains, on the dried basis, not less than 98.5% of CHNO.HCI. The molecular weight is 375.85. The structural formula is as shown.
Papaverine Hydrochloride occurs as white crystals or white crystalline powder. One gram dissolves in about 30 mL of water and in 120 mL of alcohol. It is soluble in chloroform and practically insoluble in ether.
Papaverine Hydrochloride Injection, USP, is a clear, colorless to pale-yellow solution.
Papaverine Hydrochloride, for parenteral administration, is a smooth-muscle relaxant that is available in vials containing 30 mg/mL. Each vial also contains edetate disodium 0.005%. The 10 mL vials also contain chlorobutanol 0.5% as a preservative. pH may be adjusted with sodium citrate and/or citric acid.

Chemical Properties

PAPAVERINE HYDROCHLORIDE is Crystalline Solid

Physical properties

Appearance: colorless prismatic or acicular crystal. Melting point: 147–148? °C. Relative density: 1.337 (20/4?°C). Solubility: very soluble in benzene, acetone, hot ethanol, and glacial acetic acid; soluble in concentrated sulfuric acid; slightly soluble in ether, chloroform, and carbon tetrachloride; and insoluble in water. The common crystalline salt is hydrochloride salt, papaverine hydrochloride.

History

Human beings have a long history of using opium poppy as food and narcotics, which can be dated back to the Neolithic age. The opium, which is the dried product of the opium poppy juice, is widely used as analgesics in the old and new civilizations of the old continent except the Chinese civilization.
In 1848, German chemist Georg Merck successfully isolated a new alkaloid from the opium liquor for the first time and named it as “papaverine” . He also determined the correct molecular formula of papaverine as C20 H21NO4 and prepared the papaverine hydrochloride and nitrate by recrystallization method. Then, Goldschmiedt et?al. put forward the molecular structure of papaverine by studying its oxidation products in 1883 and determined the isoquinoline ring as the core structure of papaverine in 1888 .
Since the content of papaverine in plants is very low (less than 1%) and can hardly meet the clinical needs, so Pictet and Gams proposed a synthetic method of papaverine in 1909, which makes the large-scale industrialized production of papaverine possible .
Study on the pharmacology of papaverine was first published in 1914 by Professor Pal of Vienna, who found that papaverine possessed smooth muscle relaxation effect without causing smooth muscle paralysis and can be used for the treatment of hypertension, angina, and acute uremia .

Uses

Smooth muscle relaxant found in opium. Vasodilator (cerebral)

Uses

Papaverine hydrochloride is as effective as sodium diclofenac for the short-term relief of acute renal colic pain and may be advantageous in patients with contraindications for nonsteroidal anti-inflammatory drugs. However, sodium diclofenac appears to provide a longer effective analgesia.
Papaverine hydrochloride belongs to the group of benzylisoquinoline alkaloid. It is obtained from opium poppy.
Papaverine hydrochloride has been used:
in oxygenated Krebs solution for tissue mechanics analysis
as a vasodilator in heparinized horse serum in tissue uptake technique
as an inhibitor of H-MPP+ uptake into stably transfected 293 cells expressing either extraneuronal monoamine transporter (EMT) human or EMT rat

Uses

Anti-spasmodic, The treatment of erectile dysfunction

Indications

Papaverine is mainly used for the treatment of ischemia caused by cerebral, cardiac, and peripheral vascular spasm, as well as visceral spasm of the kidney, gallbladder, or gastrointestinal tract.

brand name

Pavabid (Hoechst Marion Roussel).

General Description

White powder. pH (0.05 molar solution) 3.9. pH (2% aqueous solution) 3.3.

General Description

Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency.
Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.

Air & Water Reactions

Water soluble.

Reactivity Profile

Papaverine hydrochloride is sensitive to light. .

Health Hazard

SYMPTOMS: Symptoms of exposure to Papaverine hydrochloride may include sleepiness, slowed respiration and slowed heart beat.

Fire Hazard

Flash point data for Papaverine hydrochloride are not available, but Papaverine hydrochloride is probably combustible.

Biochem/physiol Actions

Papaverine is originally used to resolve male impotence.

Pharmacology

As a vasodilator, papaverine is a nonspecific antispasmodic drug of smooth muscle, which is especially effective on pulmonary artery, coronary artery, and great vessels, producing systemic and nonspecific hypotensive and smooth muscle relaxation effect. Papaverine has a direct effect on the smooth muscle cells by inhibiting phosphodiesterase, thus increasing the intracellular concentration of cyclic adenosine monophosphate (cAMP), which further removes the catalase calcium from cytoplasmic of vascular smooth muscle, leading to the direct smooth muscle relaxation without nerve. Papaverine can also inhibit the cardiac conduction, directly act on myocardial cells, and prolong the refractory period. No effect of papaverine on the central nervous system has been found. High dose of papaverine can cause hypotension and tachycardia.

Clinical Use

Papaverine hydrochloride is used for the treatment of ischemia induced by brain, heart, and peripheral vascular spasm, as well as visceral spasm of the kidney, bladder, or gastrointestinal tract. Besides, papaverine is also suitable for angina and arterial embolism, occasionally used for the treatment of erectile dysfunction. In recent years, papaverine hydrochloride also combines with other drugs like nimodipine to treat the vasospasm and crisis triggered by subarachnoid hemorrhage and calculi-induced acute renal colic. The main adverse effects of papaverine include liver function damage, exaggerated respiration induced by rapid parenteral administration, facial flushing, heart rate acceleration, as well as hypotension with vertigo. In addition, overdose of papaverine can lead to blurred vision, diplopia, lethargy, and weakness.

Safety Profile

Poison by ingestion, intraperitoneal, intraduodenal, intravenous, and subcutaneous routes. Human systemic effects: metabolic acidosis, pulse rate increase. An experimental teratogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also PAPAVERINE

Purification Methods

Recrystallise it from H2O. It sublimes at 140o/0.1mm. Its solubility in H2O is 5%. [Saunders & Srivastava J Pharm Pharmacol 3 78 1951, Biggs Trans Faraday Soc 50 800 1954.] The free base has m 148-150o, The picrate has m 186-189o(dec, 186-186.5o(dec) [Bobbitt J Org Chem 22 1729 1957]. [Beilstein 21 II 202, 21 III/IV 2788, 21/6 V 182.]

Papaverine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Papaverine hydrochloride Suppliers

Qinghai Pharmaceutical Factory Co., Ltd.
Tel
0971-5506700
Fax
NULL
Email
xcf@qhzhiyao.com、sqj@qhzhiyao.com
Country
China
ProdList
9
Advantage
58
Zhejiang Boxiao Bio-Pharmaceutical Co., Ltd.
Tel
0571-63280982
Email
sales@bx-biopharm.com
Country
China
ProdList
49
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
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View Lastest Price from Papaverine hydrochloride manufacturers

Weijer International Trade (Hebei) Co., Ltd
Product
Papaverine hydrochloride 61-25-6
Price
US $50.00/KG
Min. Order
1KG
Purity
>99%
Supply Ability
20tons
Release date
2023-03-16
Shaanxi Dideu Medichem Co. Ltd
Product
Papaverine Hydrochloride 61-25-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-11
Dideu Industries Group Limited
Product
Papaverine hydrochloride 61-25-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-12

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