Isoquinolin-6-ol

Product Name: Isoquinolin-6-ol
CAS No.: 7651-82-3
Chemical Name: Isoquinolin-6-ol
Synonyms: 6-Isoquinolinol;isoquinolin-6-ol;Einecs 231-612-8;Isoquinoline-6-ol;2H-Isoquinolin-6-one;6-HYDROXYISOQUINOLINE;6-Hydroxyisoquinoline96%;Isoquinolin-6-ol ISO 9001：2015 REACH;6-Hydroxyisoquinoline, 98% (Custom work);Isoquinolin-6-ol, 6-Hydroxy-2-azanaphthalene
CBNumber: CB8197713
Molecular Formula: C9H7NO
Formula Weight: 145.16
MOL File: 7651-82-3.mol

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Isoquinolin-6-ol Property

Melting point:: 220 °C
Boiling point:: 332.1±15.0 °C(Predicted)
Density: 1.260±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
pka: 9.15±0.10(Predicted)
color: Pale yellow
InChI: InChI=1S/C9H7NO/c11-9-2-1-8-6-10-4-3-7(8)5-9/h1-6,11H
InChIKey: GPVPDRHTRGTSIH-UHFFFAOYSA-N
SMILES: C1C2=C(C=C(O)C=C2)C=CN=1
CAS DataBase Reference: 7651-82-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: H942915
Product name: 6-Hydroxyisoquinoline
Packaging: 500mg
Price: $50
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-1-P4
Product name: 6-Hydroxyisoquinoline
Purity: 98%
Packaging: 1g
Price: $56
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-1-P4
Product name: 6-Hydroxyisoquinoline
Purity: 98%
Packaging: 250mg
Price: $20
Updated: 2021/12/16

Matrix Scientific

Product number: 069893
Product name: 6-Hydroxyisoquinoline
Purity: 97%
Packaging: 5g
Price: $127
Updated: 2021/12/16

AK Scientific

Product number: W8332
Product name: 6-Hydroxyisoquinoline
Packaging: 5g
Price: $212
Updated: 2021/12/16

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Isoquinolin-6-ol Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

6-Hydroxyisoquinoline is used in proteomics research such as in preparation of isoquinoline derivatives which act as protease inhibitors against trypsin. It was also used as a reagent in the study of a novel series of compounds that act as Wnt signaling pathway inhibitors and obtained by scaffold hybridization strategy from two known porcupine inhibitor classes.

Synthesis

52986-70-6

7651-82-3

(c) 6-Methoxyisoquinoline (16 g, 0.1 mol) was mixed with 48% aqueous hydrobromic acid (600 mL) and heated to reflux for 6 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water (H2O) and the pH was adjusted to alkaline with solid sodium carbonate (Na2CO3). The precipitated solid product was collected by filtration and recrystallized with isopropanol to give the final 6-hydroxyisoquinoline (12 g, 82% yield) with a melting point of 205°C. Literature reports a melting point of 218°-220°C (Lit.* 220°C).

References

[1] Patent: US4812573, 1989, A
[2] Patent: WO2004/43904, 2004, A1. Location in patent: Page 59
[3] Patent: WO2004/43931, 2004, A1. Location in patent: Page 36-37
[4] Journal of the American Chemical Society, 1947, vol. 69, p. 1944
[5] European Journal of Organic Chemistry, 2003, # 9, p. 1681 - 1686

Isoquinolin-6-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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Isoquinolin-6-ol Suppliers

China 128 France 1 Germany 1 India 5 United Kingdom 3 United States 17 Global 155

Tongchuang Pharma(Suzhou). Co., Ltd.

Tel: 0512-63263366 18912765016
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Energy Chemical

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Shanghai Longsheng chemical Co.,Ltd.

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ZEROSCHEM.CO.,LTD.

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China DongFan Chemical Co.,LTD

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Shandong Xiya Chemical Co., Ltd

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Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
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View Lastest Price from Isoquinolin-6-ol manufacturers

Henan Bao Enluo International TradeCo.，LTD

Product: Isoquinolin-6-ol 7651-82-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 50000tons
Release date: 2023-08-08

Career Henan Chemical Co

Product: Isoquinolin-6-ol 7651-82-3
Price: US $5.50/KG
Min. Order: 1IU
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-14

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Isoquinolin-6-ol ISO 9001：2015 REACH

Isoquinoline-6-ol

6-Hydroxyisoquinoline, 98% (Custom work)

7651-82-3

651-82-3

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