6-Hydroxypyrimidine-4-carboxylic acid

Product Name: 6-Hydroxypyrimidine-4-carboxylic acid
CAS No.: 6299-87-2
Chemical Name: 6-Hydroxypyrimidine-4-carboxylic acid
Synonyms: 6-oxo-3,6-dihydropyrimidine-4-carboxylic acid;6-oxo-1,6-dihydropyriMidine-4-carboxylic acid;NSC45047;4-Carboxypyrimidin-6-ol;Pyrimidin-6-ol-4-carboxylic acid;Hydroxy-4-pyriMidinecarboxylic acid;6-Oxo-3H-Pyrimidine-4-CarboxylicAci;6-oxo-3H-pyrimidine-4-carboxylic acid;6-HYDROXY-4-PYRIMIDINECARBOXYLIC ACID;4-Oxo-1H-pyrimidine-6-carboxylic acid
CBNumber: CB81010903
Molecular Formula: C5H4N2O3
Formula Weight: 140.1
MOL File: 6299-87-2.mol

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6-Hydroxypyrimidine-4-carboxylic acid Property

Melting point:: 268-270 °C
Boiling point:: 305.2±52.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder to crystal
pka: 2.77±0.20(Predicted)
color: White to Light yellow to Light red
InChI: InChI=1S/C5H4N2O3/c8-4-1-3(5(9)10)6-2-7-4/h1-2H,(H,9,10)(H,6,7,8)
InChIKey: QYGHXDAYBIFGKI-UHFFFAOYSA-N
SMILES: C1NC(=O)C=C(C(O)=O)N=1
CAS DataBase Reference: 6299-87-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S362735
Product name: 6-HYDROXY-4-PYRIMIDINECARBOXYLIC ACID
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $113
Updated: 2025/07/31

Sigma-Aldrich

Product number: S362735
Product name: 6-HYDROXY-4-PYRIMIDINECARBOXYLIC ACID
Purity: AldrichCPR
Packaging: 50MG
Price: $106
Updated: 2023/06/20

TCI Chemical

Product number: H1392
Product name: 6-Hydroxy-4-pyrimidinecarboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $103
Updated: 2025/07/31

TCI Chemical

Product number: H1392
Product name: 6-Hydroxy-4-pyrimidinecarboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $34
Updated: 2025/07/31

TRC

Product number: H953728
Product name: 6-Hydroxypyrimidine-4-carboxylicacid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

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6-Hydroxypyrimidine-4-carboxylic acid Chemical Properties,Usage,Production

Uses

As the main formic acid derivative, 6-Hydroxypyrimidine-4-carboxylic acid has the antibacterial ability of formic acid, while overcoming the irritation and corrosiveness of formic acid. It is widely used in feed and aquaculture. As an organic acid with a relatively simple structure, 6-Hydroxypyrimidine-4-carboxylic acid has good acidification and nutritional functions.

Synthesis

3473-63-0

40876-98-0

6299-87-2

In a 1 L round bottom flask, 55 g of sodium ethoxyzine acetate (1.05 eq., 0.26 mol) and 26 g of formamidine acetate (1 eq., 0.25 mol) were added to a 500 mL aqueous solution containing 10 g of sodium hydroxide. The reaction mixture was stirred at room temperature for 16 hours. Subsequently, concentrated hydrochloric acid was added slowly and dropwise to the reaction mixture until the pH dropped to 1, at which point fine solids precipitated. The mixture was continued to be stirred at 0°C for 1 hour to complete the precipitation. The solid product was collected by filtration and washed sequentially with water and ether. The resulting white solid was dried in a vacuum oven preheated to 40°C for 20 hours. Finally, grinding in methanol afforded the target compound 6-hydroxy-4-pyrimidinecarboxylic acid in 25% yield.1H NMR (dβ-DMSO) data were as follows: δ 12.88 (1H, OH), 8.24 (s, 1H), 6.83 (s, 1H).

References

[1] Patent: WO2010/20432, 2010, A2. Location in patent: Page/Page column 91
[2] European Journal of Medicinal Chemistry, 2018, vol. 149, p. 30 - 44
[3] Patent: US2011/21500, 2011, A1. Location in patent: Page/Page column 39
[4] Patent: US2011/59954, 2011, A1. Location in patent: Page/Page column 71
[5] Patent: US2011/172218, 2011, A1. Location in patent: Page/Page column 28

6-Hydroxypyrimidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

6-AMINO-PYRIMIDINE-4-CARBOXYLIC ACID

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6-Hydroxypyrimidine-4-carboxylic acid Suppliers

Americas 1 China 201 Europe 2 Germany 3 India 6 Japan 1 United Kingdom 5 United States 20 Global 239

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View Lastest Price from 6-Hydroxypyrimidine-4-carboxylic acid manufacturers

Dideu Industries Group Limited

Product: 6-Oxo-3H-pyrimidine-4-carboxylic acid 6299-87-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-Oxo-3H-pyrimidine-4-carboxylic acid 6299-87-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-Oxo-3H-pyrimidine-4-carboxylic acid 6299-87-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acidRelated Search:

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6-Oxo-3H-pyrimidine-4-carboxylic acid ISO 9001：2015 REACH

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6299-87-2

Heterocycle-Pyrimidine series

Building Blocks

PYRIMIDINE

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