6-Hydroxypyrimidine-4-carboxylic acid
- Product Name
- 6-Hydroxypyrimidine-4-carboxylic acid
- CAS No.
- 6299-87-2
- Chemical Name
- 6-Hydroxypyrimidine-4-carboxylic acid
- Synonyms
- 6-oxo-3,6-dihydropyrimidine-4-carboxylic acid;6-oxo-1,6-dihydropyriMidine-4-carboxylic acid;NSC45047;4-Carboxypyrimidin-6-ol;Pyrimidin-6-ol-4-carboxylic acid;Hydroxy-4-pyriMidinecarboxylic acid;6-Oxo-3H-Pyrimidine-4-CarboxylicAci;6-oxo-3H-pyrimidine-4-carboxylic acid;6-HYDROXY-4-PYRIMIDINECARBOXYLIC ACID;4-Oxo-1H-pyrimidine-6-carboxylic acid
- CBNumber
- CB81010903
- Molecular Formula
- C5H4N2O3
- Formula Weight
- 140.1
- MOL File
- 6299-87-2.mol
6-Hydroxypyrimidine-4-carboxylic acid Property
- Melting point:
- 268-270 °C
- Boiling point:
- 305.2±52.0 °C(Predicted)
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder to crystal
- pka
- 2.77±0.20(Predicted)
- color
- White to Light yellow to Light red
- InChI
- InChI=1S/C5H4N2O3/c8-4-1-3(5(9)10)6-2-7-4/h1-2H,(H,9,10)(H,6,7,8)
- InChIKey
- QYGHXDAYBIFGKI-UHFFFAOYSA-N
- SMILES
- C1NC(=O)C=C(C(O)=O)N=1
- CAS DataBase Reference
- 6299-87-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S362735
- Product name
- 6-HYDROXY-4-PYRIMIDINECARBOXYLIC ACID
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $113
- Updated
- 2025/07/31
- Product number
- S362735
- Product name
- 6-HYDROXY-4-PYRIMIDINECARBOXYLIC ACID
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $106
- Updated
- 2023/06/20
- Product number
- H1392
- Product name
- 6-Hydroxy-4-pyrimidinecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $103
- Updated
- 2025/07/31
- Product number
- H1392
- Product name
- 6-Hydroxy-4-pyrimidinecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $34
- Updated
- 2025/07/31
- Product number
- H953728
- Product name
- 6-Hydroxypyrimidine-4-carboxylicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
6-Hydroxypyrimidine-4-carboxylic acid Chemical Properties,Usage,Production
Uses
As the main formic acid derivative, 6-Hydroxypyrimidine-4-carboxylic acid has the antibacterial ability of formic acid, while overcoming the irritation and corrosiveness of formic acid. It is widely used in feed and aquaculture. As an organic acid with a relatively simple structure, 6-Hydroxypyrimidine-4-carboxylic acid has good acidification and nutritional functions.
Synthesis
3473-63-0
40876-98-0
6299-87-2
In a 1 L round bottom flask, 55 g of sodium ethoxyzine acetate (1.05 eq., 0.26 mol) and 26 g of formamidine acetate (1 eq., 0.25 mol) were added to a 500 mL aqueous solution containing 10 g of sodium hydroxide. The reaction mixture was stirred at room temperature for 16 hours. Subsequently, concentrated hydrochloric acid was added slowly and dropwise to the reaction mixture until the pH dropped to 1, at which point fine solids precipitated. The mixture was continued to be stirred at 0°C for 1 hour to complete the precipitation. The solid product was collected by filtration and washed sequentially with water and ether. The resulting white solid was dried in a vacuum oven preheated to 40°C for 20 hours. Finally, grinding in methanol afforded the target compound 6-hydroxy-4-pyrimidinecarboxylic acid in 25% yield.1H NMR (dβ-DMSO) data were as follows: δ 12.88 (1H, OH), 8.24 (s, 1H), 6.83 (s, 1H).
References
[1] Patent: WO2010/20432, 2010, A2. Location in patent: Page/Page column 91
[2] European Journal of Medicinal Chemistry, 2018, vol. 149, p. 30 - 44
[3] Patent: US2011/21500, 2011, A1. Location in patent: Page/Page column 39
[4] Patent: US2011/59954, 2011, A1. Location in patent: Page/Page column 71
[5] Patent: US2011/172218, 2011, A1. Location in patent: Page/Page column 28
6-Hydroxypyrimidine-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6-Hydroxypyrimidine-4-carboxylic acid Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 6-Hydroxypyrimidine-4-carboxylic acid manufacturers
- Product
- 6-Oxo-3H-pyrimidine-4-carboxylic acid 6299-87-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-09
- Product
- 6-Oxo-3H-pyrimidine-4-carboxylic acid 6299-87-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 6-Oxo-3H-pyrimidine-4-carboxylic acid 6299-87-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09