6-Hydroxyindole

Product Name: 6-Hydroxyindole
CAS No.: 2380-86-1
Chemical Name: 6-Hydroxyindole
Synonyms: 1H-INDOL-6-OL;INDOLOL;6-INDOLOL;6(1H)-indolol;6-Hydroyindole;6-HydroxyindoL;6-HYDROXYINDOLE;6-carboxylindoline;6-Hydroxyindole,97%;6-Hydroxy-1H-indole
CBNumber: CB1116076
Molecular Formula: C8H7NO
Formula Weight: 133.15
MOL File: 2380-86-1.mol

More

Less

6-Hydroxyindole Property

Melting point:: 125-128 °C
Boiling point:: 343.2±15.0 °C(Predicted)
Density: 1.327±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Slightly, Heated), Methanol (Slightly)
pka: 10.07±0.40(Predicted)
form: Shiny Crystalline Powder
color: White to off-white
Cosmetics Ingredients Functions: HAIR DYEING
Cosmetic Ingredient Review (CIR): 6-Hydroxyindole (2380-86-1)
InChI: InChI=1S/C8H7NO/c10-7-2-1-6-3-4-9-8(6)5-7/h1-5,9-10H
InChIKey: XAWPKHNOFIWWNZ-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(O)=C2)C=C1
CAS DataBase Reference: 2380-86-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,N,Xn
Risk Statements: 36/37/38-51/53-43-41-22
Safety Statements: 37/39-26-61-24-2
RIDADR: UN 3077
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT, KEEP COLD
HazardClass: 9
PackingGroup: Ⅲ
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Aquatic Chronic 2
Eye Dam. 1
Skin Sens. 1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 18805
Product name: 6-Hydroxyindole
Purity: ≥99.0% (GC)
Packaging: 1g
Price: $270
Updated: 2025/07/31

TCI Chemical

Product number: H1247
Product name: 1H-Indol-6-ol
Purity: min. 95.0 %
Packaging: 200MG
Price: $60
Updated: 2025/07/31

TCI Chemical

Product number: H1247
Product name: 1H-Indol-6-ol
Purity: min. 95.0 %
Packaging: 1G
Price: $180
Updated: 2025/07/31

TRC

Product number: H953933
Product name: 6-Hydroxyindole
Packaging: 500mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-W002438
Product name: 6-Hydroxyindole
Purity: 99.61%
Packaging: 5g
Price: $175
Updated: 2021/12/16

More

Less

6-Hydroxyindole Chemical Properties,Usage,Production

Chemical Properties

White to off-white shiny crystalline powder

Uses

Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
Reactant for asymmetrical synthesis of notoamide J as a potential biosynthetic precursor of prenylated indole alkaloids
Reactant for preparation of (quinolinyloxymethyl)isoxazolecarboxylate esters antituberculosis agents
Reactant for preparation of indolyl(propanolamine) derivatives as HIV inhibitors
Reactant for preparation of indoleoxyacetic acid derivatives as peroxisome proliferator-activated receptor agonists
Reactant for preparation of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitors

Synthesis Reference(s)

Journal of Medicinal Chemistry, 35, p. 2419, 1992 DOI: 10.1021/jm00091a010

Synthesis

Regioselective chloroacetylation of 1-pivaloylindole followed by Baeyer-Villiger oxidation offers introduction of an oxygen function into the 6-position of the indole ring. Deacylation of 6-chloroacetyl-1-pivaloylindole gives 6-hydroxyindole. The overall yield of 6-hydroxyindole from indole is 54%.

[1] K. TERANISHI; T. G; S I NAKATSUKA. ChemInform Abstract: Facile Synthesis of 6-Hydroxyindole (VII) and 6-Methoxyindole (IX) via Regioselective Friedel-Crafts Acylation and Baeyer-Villiger Oxidation.[J]. ChemInform, 1995, 26 9. DOI:10.1002/chin.199509120.

6-Hydroxyindole Preparation Products And Raw materials

Raw materials

Aluminium-nickel Benzyl chloride Ethanol N,N-Dimethylformamide Acetone NICKEL BORIDE Potassium carbonate Hydrazine hydrate Palladium Tetrahydrofuran Palladium chloride N,N-Dimethylformamide dimethyl acetal 4-Methyl-3-nitrophenol Pyrrolidine

Preparation Products

More

Less

6-Hydroxyindole Suppliers

Belgium 1 China 349 Europe 2 France 1 Germany 4 India 7 Japan 1 Slovakia 1 Switzerland 5 Ukraine 1 United Kingdom 18 United States 62 Global 452

Hubei jian chu biological technology co., LTD

Tel: 027-65528353 13554206703
Email: HBJC3279834739@foxmail.com
Country: China
ProdList: 1009
Advantage: 58

Cangzhou Dimai Technology Co., Ltd

Tel: 1351-2466848 13512466848
Fax: QQ:94204388
Email: hbdypharm@163.com
Country: China
ProdList: 254
Advantage: 58

Honghanyanxin Pharm

Tel: 0551-62626652 19334025048
Email: sales-honghanyanxin@aliyun.com
Country: China
ProdList: 1251
Advantage: 58

Beijing Baize-Ruicheng Pharmaceutical Technology Co., Ltd.

Tel: 17813701174
Email: 17813701174@163.com
Country: China
ProdList: 30
Advantage: 58

Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd

Tel: 13970866816
Email: info@rochipharma.com
Country: China
ProdList: 305
Advantage: 58

Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.

Tel: 027-027-65385071 17771822910
Fax: 027-65526669
Email: shelleyl.meng@foxmail.com
Country: China
ProdList: 2352
Advantage: 58

Shanghai Rochi Pharmaceutical Co., Ltd.

Tel: 021-38751876 15000076078
Fax: 021-50275764
Email: Info@rochipharma.com
Country: China
ProdList: 611
Advantage: 55

Lihe Biotechnology (Shandong) Co., Ltd

Tel: 13176691201 15588824841
Email: lhswsd@126.com
Country: China
ProdList: 32
Advantage: 58

Hubei Yiling Biotechnology Co., Ltd

Tel: 027-027-65526929 17771822910
Email: hxry001@foxmail.com
Country: China
ProdList: 60
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

More

Less

View Lastest Price from 6-Hydroxyindole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 6-Hydroxyindole 2380-86-1
Price: US $9.85/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 m
Release date: 2024-11-29

Cangzhou Kangrui Pharma Tech Co. Ltd.,

Product: 6-Hydroxyindole 2380-86-1
Price: US $0.00-0.00/g
Min. Order: 100g
Purity: 98%
Supply Ability: 10kgs
Release date: 2025-02-28

LY Global chemicals co.,ltd .

Product: 6-Hydroxyindole 2380-86-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%Min
Supply Ability: 1000kg
Release date: 2023-03-12

2380-86-1, 6-HydroxyindoleRelated Search:

Indometacin Indole-3-butyric acid Indole-3-acetic acid Indole Indoline-2-carboxylic acid Indazole-3-carboxylic acid 3-HYDROXY-1-PHENYL-6-PYRIDAZONE 6-Cyanoindole 6-cyanopyridine-3-boronic acid 6-CHLOROINDOLE-3-ACETONITRILE 6-chloropyrazine-2-carbonitrile 6-CHLORO-2,3-DIHYDRO-1H-INDOLE 6-Cyanopyridine-2-carboxylic acid 6-Chloroindole 2,3-DIHYDRO-1H-INDOLE-6-CARBONITRILE HYDROCHLORIDE 6-Hydroxyindolin-2-one 6-Hydroxyindazole 6-Oxo-3H-pyrimidine-4-carboxylic acid

1H-INDOL-6-OL

6-INDOLOL

6-HYDROXYINDOLE

INDOLOL

5.7-dichloroindole 2380-86-1

6-Hydroyindole

6-Hydroxy-1H-indole 95%

6-Hydroxyindole in stock Factory

Indolol，6-Hydroxyindole

6-Hydroxyindole ,98%

6-Hydroxyindole,97%

6-HydroxyindoleIndolol

6-Hydroxy-1H-indole

6(1H)-indolol

6-Hydroxyindole, 97% 5GR

6-carboxylindoline

6-monohydroxyindole

6-Hydroxyindole≥ 99.5% (HPLC)

6-Hydroxyindole >=99.0% (GC)

6-Hydroxyindole, 98%, reagent grade

6-HydroxyindoL

Pindolol Impurity 10

6-Hydroxyindole, 10 mM in DMSO

2380-86-1

Indoles

Heterocyclic Building Blocks

Building Blocks

Heterocycle-Indole series

Indole

blocks

IndolesOxindoles

Indoles and derivatives

Heterocycles series

Indoline & Oxindole

Indoles