N,N-Dimethylformamide dimethyl acetal
- Product Name
- N,N-Dimethylformamide dimethyl acetal
- CAS No.
- 4637-24-5
- Chemical Name
- N,N-Dimethylformamide dimethyl acetal
- Synonyms
- DMF-DMA;1,1-dimethoxy-n,n-dimethyl-methanamin;DMF-DIMETHYLACETAL;1,1-DIMETHOXYTRIMETHYLAMINE;(Dimethylamino)dimethoxymethane;DIMETHYLFORMAMIDEDIMETHYLACETAL;N-(Dimethoxymethyl)dimethylamine;Dimethoxy-N,N-dimethylmethanamine;N,N-Dimethylformamide dimethyl acetal, 95% (1,1-Dimethoxytrimethylamine);METHYL-8
- CBNumber
- CB8178244
- Molecular Formula
- C5H13NO2
- Formula Weight
- 119.16
- MOL File
- 4637-24-5.mol
N,N-Dimethylformamide dimethyl acetal Property
- Melting point:
- -85°C
- Boiling point:
- 102-103 °C/720 mmHg (lit.)
- Density
- 0.897 g/mL at 25 °C (lit.)
- vapor pressure
- 34.5hPa at 20℃
- refractive index
- n20/D 1.396(lit.)
- Flash point:
- 45 °F
- storage temp.
- Store below +30°C.
- solubility
- Miscible with most organic solvents.
- form
- Solid
- pka
- 5.00±0.50(Predicted)
- color
- White to off-white
- PH
- 7 (H2O)
- explosive limit
- 1.3-17.7%(V)
- Water Solubility
- hydrolysis
- Sensitive
- Moisture Sensitive
- BRN
- 506020
- Exposure limits
- ACGIH: TWA 200 ppm; STEL 250 ppm (Skin)
OSHA: TWA 200 ppm(260 mg/m3)
NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3) - LogP
- 0.750 (est)
- CAS DataBase Reference
- 4637-24-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5)
- EPA Substance Registry System
- Methanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5)
Safety
- Hazard Codes
- F,Xn,Xi
- Risk Statements
- 11-22-36/37/38-36/38-20-20/21/22-10-52
- Safety Statements
- 16-26-36/37-36/37/39-33-29-7/9
- RIDADR
- UN 3271 3/PG 2
- WGK Germany
- 1
- F
- 21
- Autoignition Temperature
- 155 °C
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29225000
- Toxicity
- LD50 orally in Rabbit: > 5000 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H317May cause an allergic skin reaction
H318Causes serious eye damage
H332Harmful if inhaled
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 8.03068
- Product name
- N,N-Dimethylformamide dimethyl acetal
- Purity
- for synthesis
- Packaging
- 25mL
- Price
- $56.8
- Updated
- 2025/07/31
- Product number
- 140732
- Product name
- N,N-Dimethylformamide dimethyl acetal
- Purity
- technical grade, 94%
- Packaging
- 25ml
- Price
- $57.76
- Updated
- 2025/07/31
- Product number
- 140732
- Product name
- N,N-Dimethylformamide dimethyl acetal
- Purity
- technical grade, 94%
- Packaging
- 2.5l
- Price
- $1340
- Updated
- 2025/07/31
- Product number
- 8.03068
- Product name
- N,N-Dimethylformamide dimethyl acetal
- Purity
- for synthesis
- Packaging
- 1mL
- Price
- $34.2
- Updated
- 2024/03/01
- Product number
- 8.03068
- Product name
- N,N-Dimethylformamide dimethyl acetal
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $163
- Updated
- 2024/03/01
N,N-Dimethylformamide dimethyl acetal Chemical Properties,Usage,Production
Chemical Properties
clear colourless liquid
Uses
N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.
Uses
Used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.
Uses
1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes.
Definition
ChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica ions
General Description
Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.
Flammability and Explosibility
Highly flammable
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications
Synthesis
124-41-4
68-12-2
4637-24-5
A method for synthesizing N,N-dimethylformamide dimethyl acetal, comprising the steps of (1) heating N,N-dimethylformamide to 70°C, mixing with dimethyl sulfate in a molar ratio of 1:1 and reacting for 4 hours after the end of dropwise addition to obtain the imine complex, and then cooling to room temperature; (2) adding solid sodium methanol to 200 solvent oil, dispersing it by ultrasonication, adjusting the temperature to 25 ℃ and maintained, dropwise addition of the imine complex, the reaction for 2 hours and then filtered, the filtrate often pressure fractionation, collection of 105-108 ℃ fraction, to obtain N,N-dimethylformamide dimethyl acetal, the yield was 75.3%, purity of 97%; wherein the molar ratio of sodium methanol to the imine complex is 1:1. The synthesis of the N,N-dimethylformamide dimethyl acetal of Example 6 is the same as that of Example 2, the The difference is that the organic solvent of this embodiment is a mixed solvent oil: D40 solvent oil, D60 solvent oil and 260 solvent oil, with a volume ratio of 2:1:1, to obtain N,N-dimethylformamide dimethyl acetal with a yield of 85.4% and a purity of 97%.
References
[1] Patent: CN106083611, 2016, A. Location in patent: Paragraph 0034-0037; 0048-0049
N,N-Dimethylformamide dimethyl acetal Preparation Products And Raw materials
Raw materials
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View Lastest Price from N,N-Dimethylformamide dimethyl acetal manufacturers
- Product
- N,N-Dimethylformamide Dimethyl Acetal 4637-24-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-27
- Product
- N,N-Dimethylformamide dimethyl acetal 4637-24-5
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 10 Tons
- Release date
- 2025-06-25
- Product
- N,N-Dimethylformamide dimethyl acetal 4637-24-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-12