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N,N-Dimethylformamide dimethyl acetal

Product Name
N,N-Dimethylformamide dimethyl acetal
CAS No.
4637-24-5
Chemical Name
N,N-Dimethylformamide dimethyl acetal
Synonyms
DMF-DMA;1,1-dimethoxy-n,n-dimethyl-methanamin;DMF-DIMETHYLACETAL;1,1-DIMETHOXYTRIMETHYLAMINE;(Dimethylamino)dimethoxymethane;DIMETHYLFORMAMIDEDIMETHYLACETAL;N-(Dimethoxymethyl)dimethylamine;Dimethoxy-N,N-dimethylmethanamine;N,N-Dimethylformamide dimethyl acetal, 95% (1,1-Dimethoxytrimethylamine);METHYL-8
CBNumber
CB8178244
Molecular Formula
C5H13NO2
Formula Weight
119.16
MOL File
4637-24-5.mol
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N,N-Dimethylformamide dimethyl acetal Property

Melting point:
-85°C
Boiling point:
102-103 °C/720 mmHg (lit.)
Density 
0.897 g/mL at 25 °C (lit.)
vapor pressure 
34.5hPa at 20℃
refractive index 
n20/D 1.396(lit.)
Flash point:
45 °F
storage temp. 
Store below +30°C.
solubility 
Miscible with most organic solvents.
form 
Solid
pka
5.00±0.50(Predicted)
color 
White to off-white
PH
7 (H2O)
explosive limit
1.3-17.7%(V)
Water Solubility 
hydrolysis
Sensitive 
Moisture Sensitive
BRN 
506020
Exposure limits
ACGIH: TWA 200 ppm; STEL 250 ppm (Skin)
OSHA: TWA 200 ppm(260 mg/m3)
NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3)
LogP
0.750 (est)
CAS DataBase Reference
4637-24-5(CAS DataBase Reference)
NIST Chemistry Reference
Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5)
EPA Substance Registry System
Methanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5)
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Safety

Hazard Codes 
F,Xn,Xi
Risk Statements 
11-22-36/37/38-36/38-20-20/21/22-10-52
Safety Statements 
16-26-36/37-36/37/39-33-29-7/9
RIDADR 
UN 3271 3/PG 2
WGK Germany 
1
F 
21
Autoignition Temperature
155 °C
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29225000
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H317May cause an allergic skin reaction

H318Causes serious eye damage

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.03068
Product name
N,N-Dimethylformamide dimethyl acetal
Purity
for synthesis
Packaging
1mL
Price
$34.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03068
Product name
N,N-Dimethylformamide dimethyl acetal
Purity
for synthesis
Packaging
25mL
Price
$64.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03068
Product name
N,N-Dimethylformamide dimethyl acetal
Purity
for synthesis
Packaging
100mL
Price
$163
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03068
Product name
N,N-Dimethylformamide dimethyl acetal
Purity
for synthesis
Packaging
500mL
Price
$399
Updated
2024/03/01
Sigma-Aldrich
Product number
140732
Product name
N,N-Dimethylformamide dimethyl acetal
Purity
technical grade, 94%
Packaging
25ml
Price
$64.6
Updated
2024/03/01
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N,N-Dimethylformamide dimethyl acetal Chemical Properties,Usage,Production

Chemical Properties

clear colourless liquid

Uses

N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

Uses

Used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.

Uses

1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes.

Definition

ChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica ions

General Description

Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.

Flammability and Explosibility

Highly flammable

N,N-Dimethylformamide dimethyl acetal Preparation Products And Raw materials

Raw materials

Preparation Products

(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE (1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL 1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-TERT-BUTYL 6-METHYL 3-FORMYL-1H-INDOLE-1,6-DICARBOXYLATE ETHYL 1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE 3-BROMOCHROMONE 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBONITRILE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE METHYL 4-AMINO-6-INDOLECARBOXYLATE Indole-6-carboxaldehyde ETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE (1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANAMINE ETHYL 2-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 7-Hydroxyindole 6-HYDROXYMETHYLINDOLE ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-AMINE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANAMINE 3-NITROBENZO[B]FURAN-5-OL ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONITRILE 3-NITROISONICOTINALDEHYDE (5-METHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL 2-AMINO-4-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID [1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOL-4-YL]METHANOL 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-AMINE (5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL 4-(Pyridin-3-yl)pyrimidin-2-amine 1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBONITRILE Indole-7-carboxaldehyde 4-Aminomethyl-1-methylpyrazole 5-Hydroxyindole Indole-6-carboxylic acid 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXAMIDE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE
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N,N-Dimethylformamide dimethyl acetal Suppliers

Americas 1 Austria 1 Belgium 4 Canada 7 China 530 Europe 4 France 3 Germany 15 India 79 Japan 8 Norway 1 Singapore 1 Slovakia 1 South Korea 1 Switzerland 4 United Kingdom 17 United States 58 Global 735
CM Fine Chemicals
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Matrix Fine Chemicals GmbH
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SIGMA-RBI
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Biosynth AG
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Switzerland
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View Lastest Price from N,N-Dimethylformamide dimethyl acetal manufacturers

Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
Product
N,N-Dimethylformamide dimethyl acetal 4637-24-5
Price
US $12000.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200 tons
Release date
2024-04-16
Hebei Chuanghai Biotechnology Co,.LTD
Product
N,N-Dimethylformamide dimethyl acetal 4637-24-5
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-14
Nanjing Liskon Biological Technology Co., Ltd
Product
N,N-Dimethylformamide dimethyl acetal 4637-24-5
Price
US $0.00/KG
Min. Order
25KG
Purity
≥99.0%
Supply Ability
5tons
Release date
2024-06-14

4637-24-5, N,N-Dimethylformamide dimethyl acetalRelated Search:

N,N-Dimethylformamide Dimethyl fumarate Acetal Dimethyl carbonate 1,1-Di-tert-butoxytrimethylamine Dimethyl ether ETHANE Dimethylamine Dimethyl sulfate Dimethyl sulfide Dimethyl sulfoxide N,N'-Dimethylpiperazine N,N'-Diemthyl-N-Methyllisonipecotamide N,N-Dimethylallylamine N,N-Dimethylacrylamide N,N-Dimethylglycine N,N-DIMETHYLFORMAMIDE DIBENZYL ACETAL 2-Dimethylamino-1,3-dioxolane

  • 1,1-dimethoxy-n,n-dimethyl-methanamin
  • Dimethoxy(dimethylamino)methane
  • Dimethoxy-N,N-dimethylmethanamine
  • N-(Dimethoxymethyl)dimethylamine
  • N,N-Dimethylfirmanmidedimethylacetal
  • N,N-Dimethylformamide dimethyl acetal, 95% (1,1-Dimethoxytrimethylamine)
  • N,N-Dimethylformamide dimethyl acetal, ca 97%
  • Methanamine, 1,1-dimethoxy-N,N-dimethyl-
  • esterate m
  • n,n-dimethylformamide dimethyl acetal solution
  • N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL (DMF-DMA)
  • 1,1-Dimethoxytrimethylamin
  • N,N -DIMETHYL FORMAMIDE DIMETHYL ACETYL
  • N,N'-Dimethylformanimide dimethyl acetal
  • N,N-Dimethylformamide Dimethyl Acetal [for Esterification] (0.5ml*10)
  • (Dimethylamino)dimethoxymethane
  • (Dimethylamino)formaldehyde
  • Dimethoxy-N,N-dimethylmethylamine
  • N,N-Dimethylformamide dimethyl acetal ,95%
  • (Dimethylamino)formaldehyde dimethyl acetal
  • Dimethyl(dimethoxymethyl)amine
  • Dimethylaminomethanal dimethyl acetal
  • N,N-Dimethyl-α,α-dimethoxymethanamine
  • N,N-Dimethylformamide Dimethyl Acetal [for Esterification]
  • 1,1-Dimethoxy-N,N-dimethylmethylamine, 1,1-Dimethoxytrimethylamine
  • N,N-Dimethylformamide dim
  • Trimethylamine, 1,1-dimethoxy-
  • N,N-DIMETHYLDIMETHOXYMETHYLAMINE
  • N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL
  • N-DIMETHOXYMETHYL-N,N-DIMETHYLAMINE
  • DIMETHYLFORMAMIDEDIMETHYLACETAL
  • DMF-DIMETHYLACETAL
  • DMF-DMA
  • AURORA KA-683
  • METHYL-8 REAGENT
  • METHYL-8(R) REAGENT
  • METHYL-8
  • DMFDMA (DMFA)
  • 1,1-DIMETHOXYTRIMETHYLAMINE
  • 1,1-DIMETHOXY-N,N-DIMETHYL METHANAMINE
  • 1,1-DIMETHOXY-N,N-DIMETHYLMETHYLAMINE
  • dimethylformamidediemthylacetal
  • N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL, 9 4%
  • N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL, D ERIVATIZATION GRADE
  • DMFDMA [N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL]
  • DmfDmaAcetal
  • N,N-Dimethylformamide dimethyl acetal, 97+%
  • N,N-dimethyl for mamide dimethyl acctel
  • DMFDMA [N
  • N-DiMethylforMaMide diMethyl acetal]
  • N,N-DiMethylforMaMide diMethylacetal(DMFDA)
  • N,N-DiMethylforMaMide diMethyl acetal, ca. 97% 100GR
  • N,N-DiMethylforMaMide diMethyl acetal, ca. 97% 25GR
  • N,N-DiMethylforMaMide diMethyl acetal, ca. 97% 500GR
  • N,N-Dimethylformamide dimethyl acetal, ca. 97%
  • N,N-Dimethylformamide Dimethyl Acetal￡¨DMADMF￡
  • N,N-DiMethylforMaMide diMethyl acetal, ca. 97%, AcroSeal
  • N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL FO