1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

Product Name: 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
CAS No.: 55314-16-4
Chemical Name: 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
Synonyms: 4G-951;Imatinib Impurity 19;Imatinib Impurity 74;Imatinib EP Impurity A;Imatinib USP Impurity A;Nilotinib??Intermediates?B;Imatinib Related Compound A;Imatinib Dimethylamino Impurity;3-Dimethylamino-1-pyridin-3-yl-pr;3-[3-(Dimethylamino)acryloyl]pyridine
CBNumber: CB1406106
Molecular Formula: C10H12N2O
Formula Weight: 176.22
MOL File: 55314-16-4.mol

More

Less

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Property

Melting point:: 86-88
Boiling point:: 281.4±36.0 °C(Predicted)
Density: 1.070±0.06 g/cm3(Predicted)
vapor pressure: 0.049Pa at 20℃
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in chloroform and dichloromethane.
form: powder to crystal
pka: 6.19±0.70(Predicted)
color: Light yellow to Brown
InChI: InChI=1S/C10H12N2O/c1-12(2)7-5-10(13)9-4-3-6-11-8-9/h3-8H,1-2H3
InChIKey: MZLRFUCMBQWLNV-FNORWQNLSA-N
SMILES: C(C1=CC=CN=C1)(=O)C=CN(C)C
LogP: 0.26 at 20℃ and pH7.2
Surface tension: 71.8mN/m at 1.008g/L and 20℃
CAS DataBase Reference: 55314-16-4(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D3949
Product name: 2-(Dimethylamino)vinyl 3-Pyridyl Ketone
Purity: >98.0%(GC)
Packaging: 1g
Price: $68
Updated: 2023/06/20

TCI Chemical

Product number: D3949
Product name: 2-(Dimethylamino)vinyl 3-Pyridyl Ketone
Purity: >98.0%(GC)
Packaging: 5g
Price: $204
Updated: 2023/06/20

Alfa Aesar

Product number: H54187
Product name: 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%
Packaging: 5g
Price: $208
Updated: 2021/12/16

Alfa Aesar

Product number: H54187
Product name: 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%
Packaging: 1g
Price: $53.2
Updated: 2021/12/16

Alfa Aesar

Product number: H54187
Product name: 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%
Packaging: 250mg
Price: $17.8
Updated: 2021/12/16

More

Less

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Chemical Properties,Usage,Production

Description

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours.

Chemical Properties

Off-White Solid

Uses

Rasagiline intermediate

Uses

3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate.

Solubility in organics

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane.

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide N,N-Dimethylformamide dimethyl acetal 3-Acetylpyridine

Preparation Products

More

Less

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Suppliers

Americas 1 Canada 1 China 199 Europe 1 Germany 1 India 20 United Kingdom 6 United States 24 Global 253

Yangzhou QinYuan Pharmaceutical Co., Ltd.

Tel: 0514-80939770 13773367191
Fax: 0514-82664689
Email: yzqyyykj@163.com
Country: China
ProdList: 242
Advantage: 55

Shandong Xuanshuo Pharmaceutical Technology Co. LTD

Tel: 15269103900
Email: suchangzhou@shiningpharm.com
Country: China
ProdList: 265
Advantage: 58

Minglong (Xianning) Pharmaceutical Co., LTD

Tel: 155-7155-6913 15571556913
Email: 354024111@qq.com
Country: China
ProdList: 2618
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

More

Less

View Lastest Price from 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Dideu Industries Group Limited

Product: 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

55314-16-4, 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-oneRelated Search:

3-Dimethylaminopropylamine 4-Dimethylaminobenzaldehyde 4-Dimethylaminopyridine 2-Aminopyridine 3-Aminopyridine 4-Dimethylaminobenzoic acid N-Desmethyl Imatinib N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine 1-[2-[BIS(TERT-BUTYL)PHOSPHINO]PHENYL]-3,5-DIPHENYL-1H-PYRAZOLE 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone 1-(4,6-dibromothieno[3,4-b]thiophen-2-yl)-2-ethylhexan-1-one 1-(4,6-dibroMo-3-fluorothieno[3,4-b]thiophen-2-yl)-2ethylhexan-1-one 1-(2,3-Dichlorophenyl)piperazine hydrochloride N-DESMETHYL IMATINIB 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide Imatinib Impurity 7 Imatinib Meta-methyl-piperazine Impurity 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid

2-DiMethylaMino-1-(3-pyridyl)-2-propene-1-one

3-[3-(Dimethylamino)acryloyl]pyridine

2-(Dimethylamino)ethenyl 3-Pyridyl Ketone 3-(Dimethylamino)-1-(3-pyridyl)-2-propen-1-one 3-[3-(Dimethylamino)acryloyl]pyridine

(E)-3-DIMETHYLAMINO-1-PYRIDIN-3-YL-PROPENONE

3-diMethylaMino-1-(3-pyridyl)-2-propen-1-one, 3-(N,N-diMethylaMino)-1-(pyridin-3-yl)prop-2-en-1-one, 3-(diMethylaMino)-1-(pyridin-3-yl)prop-2-en-1-one

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one

(2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one

(E)-3-dimethylamino-1-(3-pyridyl)prop-2-en-1-one

3-dimethylamino-1-(3-pyridyl)prop-2-en-1-one

3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one

4G-951

Imatinib Dimethylamino Impurity

Imatinib USP Impurity A

3-(DIMETHYLAMINO)-1-(3-PYRIDINYL)-2-PROPEN-1-ONE

1-(3-PYRIDYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE

Imatinib Related Compound A

3-(Dimethylamino)-1-pyridin-3-ylprop-2-en-1-one

2-propen-1-one,3-（dimethylamino）-1-（3-pyridinyl）

3-Dimethylamino-1-(pyridin-3-yl)propenone

1-(3-PYRIDYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE 95%

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one ,97%

3-(Dimethylamino)-1-(3-pyridinyl)-2-propene-1-one

Imatinib Impurity 19

2-(DiMethylaMino)vinyl 3-Pyridyl Ketone

Imatinib EP Impurity A

2-(Dimethylamino)vinyl3-PyridylKetone&gt

Imatinib Dimethylamino Impurity Certified Reference Standard

2-(Dimethylamino)ethenyl 3-Pyridyl Ketone

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one ISO 9001：2015 REACH

Imatinib EP Impurity A (Imatinib Dimethylamino Impurity)

Nilotinib??Intermediates?B

1 - (3-pyridyl) - 3 - (dimethylamino) - 2-propene-1-one

3-Dimethylamino-1-pyridin-3-yl-pr

Imatinib Dimethylamino ImpurityQ: What is Imatinib Dimethylamino Impurity Q: What is the CAS Number of Imatinib Dimethylamino Impurity Q: What is the storage condition of Imatinib Dimethylamino Impurity Q: What are the applications of Imatinib Dimethylamino Impurity

2-(Dimethylamino)vinyl 3-Pyridyl Ketone, ≥ 95.0%

Imatinib Impurity 74

55314-16-4

Intermediate of Imatinib

Intermediates

Chemical Amines

Amines

Bases & Related Reagents

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals

Heterocycles