1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

Product Name: 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
CAS No.: 55314-16-4
Chemical Name: 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
Synonyms: 4G-951;Imatinib Impurity 19;Imatinib Impurity 74;Imatinib EP Impurity A;Imatinib USP Impurity A;Nilotinib??Intermediates?B;Imatinib Related Compound A;Imatinib Dimethylamino Impurity;3-Dimethylamino-1-pyridin-3-yl-pr;3-[3-(Dimethylamino)acryloyl]pyridine
CBNumber: CB1406106
Molecular Formula: C10H12N2O
Formula Weight: 176.22
MOL File: 55314-16-4.mol

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1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Property

Melting point:: 86-88
Boiling point:: 281.4±36.0 °C(Predicted)
Density: 1.070±0.06 g/cm3(Predicted)
vapor pressure: 0.049Pa at 20℃
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in chloroform and dichloromethane.
form: powder to crystal
pka: 6.19±0.70(Predicted)
color: Light yellow to Brown
InChI: InChI=1S/C10H12N2O/c1-12(2)7-5-10(13)9-4-3-6-11-8-9/h3-8H,1-2H3
InChIKey: MZLRFUCMBQWLNV-FNORWQNLSA-N
SMILES: C(C1=CC=CN=C1)(=O)C=CN(C)C
LogP: 0.26 at 20℃ and pH7.2
Surface tension: 71.8mN/m at 1.008g/L and 20℃
CAS DataBase Reference: 55314-16-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3949
Product name: 2-(Dimethylamino)vinyl 3-Pyridyl Ketone
Purity: >98.0%(GC)
Packaging: 1g
Price: $68
Updated: 2023/06/20

TCI Chemical

Product number: D3949
Product name: 2-(Dimethylamino)vinyl 3-Pyridyl Ketone
Purity: >98.0%(GC)
Packaging: 5g
Price: $204
Updated: 2023/06/20

TRC

Product number: D462145
Product name: 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one
Packaging: 2g
Price: $195
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22332
Product name: 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one
Packaging: 5G
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: B886
Product name: 3-(Dimethylamino)-1-(3-pyridinyl)-2-propene-1-one
Packaging: 500g
Price: $235
Updated: 2021/12/16

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1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Chemical Properties,Usage,Production

Description

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours.

Chemical Properties

Off-White Solid

Uses

Rasagiline intermediate

Uses

3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate.

Synthesis

350-03-8

4637-24-5

55314-16-4

Example-2: Preparation of 3-dimethylamino-1-pyridin-3-ylacrylone A: 3-acetylpyridine (25 g, 0.20 mol), N,N-dimethylformamide dimethyl acetal (37 g, 0.31 mol) and acetic acid (2.5 mL) were mixed and heated to react for 2 hrs at 90-95°C while successive removal of methanol generated. Upon completion of the reaction, the excess methanol in the reaction was removed by distillation under reduced pressure. The reaction mixture was diluted with water and extracted with dichloromethane (125 mL). The organic layer was washed with water and subsequently concentrated to dryness under reduced pressure to afford 34 g (92% yield) of 1-(3-pyridinyl)-3-(dimethylamino)-2-propen-1-one with a purity of 99.1% by HPLC analysis.

Solubility in organics

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane.

References

[1] Synlett, 2016, vol. 27, # 15, p. 2233 - 2236
[2] RSC Advances, 2018, vol. 8, # 47, p. 26828 - 26836
[3] Molecules, 2009, vol. 14, # 10, p. 4166 - 4179
[4] Patent: WO2011/39782, 2011, A1. Location in patent: Page/Page column 14
[5] Organic Process Research and Development, 2008, vol. 12, # 3, p. 490 - 495

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide N,N-Dimethylformamide dimethyl acetal 3-Acetylpyridine

Preparation Products

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1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Suppliers

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View Lastest Price from 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one manufacturers

Shandong Jihui Chemical Co., Ltd.

Product: 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: Purity: 99%
Supply Ability: 500tons
Release date: 2025-07-21

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Dideu Industries Group Limited

Product: 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-25

55314-16-4, 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-oneRelated Search:

3-Dimethylaminopropylamine 4-Dimethylaminobenzaldehyde 4-Dimethylaminopyridine 2-Aminopyridine 3-Aminopyridine 4-Dimethylaminobenzoic acid N-Desmethyl Imatinib N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine 1-[2-[BIS(TERT-BUTYL)PHOSPHINO]PHENYL]-3,5-DIPHENYL-1H-PYRAZOLE 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone 1-(4,6-dibromothieno[3,4-b]thiophen-2-yl)-2-ethylhexan-1-one 1-(4,6-dibroMo-3-fluorothieno[3,4-b]thiophen-2-yl)-2ethylhexan-1-one 1-(2,3-Dichlorophenyl)piperazine hydrochloride N-DESMETHYL IMATINIB 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide Imatinib Impurity 7 Imatinib Meta-methyl-piperazine Impurity 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid

2-DiMethylaMino-1-(3-pyridyl)-2-propene-1-one

3-[3-(Dimethylamino)acryloyl]pyridine

2-(Dimethylamino)ethenyl 3-Pyridyl Ketone 3-(Dimethylamino)-1-(3-pyridyl)-2-propen-1-one 3-[3-(Dimethylamino)acryloyl]pyridine

(E)-3-DIMETHYLAMINO-1-PYRIDIN-3-YL-PROPENONE

3-diMethylaMino-1-(3-pyridyl)-2-propen-1-one, 3-(N,N-diMethylaMino)-1-(pyridin-3-yl)prop-2-en-1-one, 3-(diMethylaMino)-1-(pyridin-3-yl)prop-2-en-1-one

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one

(2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one

(E)-3-dimethylamino-1-(3-pyridyl)prop-2-en-1-one

3-dimethylamino-1-(3-pyridyl)prop-2-en-1-one

3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one

4G-951

Imatinib Dimethylamino Impurity

Imatinib USP Impurity A

3-(DIMETHYLAMINO)-1-(3-PYRIDINYL)-2-PROPEN-1-ONE

1-(3-PYRIDYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE

Imatinib Related Compound A

3-(Dimethylamino)-1-pyridin-3-ylprop-2-en-1-one

2-propen-1-one,3-（dimethylamino）-1-（3-pyridinyl）

3-Dimethylamino-1-(pyridin-3-yl)propenone

1-(3-PYRIDYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE 95%

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one ,97%

3-(Dimethylamino)-1-(3-pyridinyl)-2-propene-1-one

Imatinib Impurity 19

2-(DiMethylaMino)vinyl 3-Pyridyl Ketone

Imatinib EP Impurity A

2-(Dimethylamino)vinyl3-PyridylKetone&gt

Imatinib Dimethylamino Impurity Certified Reference Standard

2-(Dimethylamino)ethenyl 3-Pyridyl Ketone

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one ISO 9001：2015 REACH

Imatinib EP Impurity A (Imatinib Dimethylamino Impurity)

Nilotinib??Intermediates?B

1 - (3-pyridyl) - 3 - (dimethylamino) - 2-propene-1-one

3-Dimethylamino-1-pyridin-3-yl-pr

Imatinib Dimethylamino ImpurityQ: What is Imatinib Dimethylamino Impurity Q: What is the CAS Number of Imatinib Dimethylamino Impurity Q: What is the storage condition of Imatinib Dimethylamino Impurity Q: What are the applications of Imatinib Dimethylamino Impurity

2-(Dimethylamino)vinyl 3-Pyridyl Ketone, ≥ 95.0%

Imatinib Impurity 74

3-Dimethylamino-1-pyridin-3-yl-2-propen-1-one

55314-16-4

Intermediate of Imatinib

Intermediates

Chemical Amines

Amines

Bases & Related Reagents

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals

Heterocycles