ChemicalBook > CAS DataBase List > 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
- Product Name
- 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
- CAS No.
- 55314-16-4
- Chemical Name
- 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
- Synonyms
- 4G-951;Imatinib Impurity 19;Imatinib Impurity 74;Imatinib EP Impurity A;Imatinib USP Impurity A;Nilotinib??Intermediates?B;Imatinib Related Compound A;Imatinib Dimethylamino Impurity;3-Dimethylamino-1-pyridin-3-yl-pr;3-[3-(Dimethylamino)acryloyl]pyridine
- CBNumber
- CB1406106
- Molecular Formula
- C10H12N2O
- Formula Weight
- 176.22
- MOL File
- 55314-16-4.mol
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1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Property
- Melting point:
- 86-88
- Boiling point:
- 281.4±36.0 °C(Predicted)
- Density
- 1.070±0.06 g/cm3(Predicted)
- vapor pressure
- 0.049Pa at 20℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in chloroform and dichloromethane.
- form
- powder to crystal
- pka
- 6.19±0.70(Predicted)
- color
- Light yellow to Brown
- InChI
- InChI=1S/C10H12N2O/c1-12(2)7-5-10(13)9-4-3-6-11-8-9/h3-8H,1-2H3
- InChIKey
- MZLRFUCMBQWLNV-FNORWQNLSA-N
- SMILES
- C(C1=CC=CN=C1)(=O)C=CN(C)C
- LogP
- 0.26 at 20℃ and pH7.2
- Surface tension
- 71.8mN/m at 1.008g/L and 20℃
- CAS DataBase Reference
- 55314-16-4(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29333990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- D3949
- Product name
- 2-(Dimethylamino)vinyl 3-Pyridyl Ketone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $68
- Updated
- 2023/06/20
TCI Chemical
- Product number
- D3949
- Product name
- 2-(Dimethylamino)vinyl 3-Pyridyl Ketone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $204
- Updated
- 2023/06/20
Alfa Aesar
- Product number
- H54187
- Product name
- 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%
- Packaging
- 1g
- Price
- $53.2
- Updated
- 2021/12/16
Alfa Aesar
- Product number
- H54187
- Product name
- 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%
- Packaging
- 5g
- Price
- $208
- Updated
- 2021/12/16
Alfa Aesar
- Product number
- H54187
- Product name
- 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%
- Packaging
- 250mg
- Price
- $17.8
- Updated
- 2021/12/16
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1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Chemical Properties,Usage,Production
Description
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours.
Chemical Properties
Off-White Solid
Uses
Rasagiline intermediate
Uses
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate.
Solubility in organics
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane.
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
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1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
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View Lastest Price from 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
Dideu Industries Group Limited
- Product
- 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
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