3-Acetylpyridine
Identification Description Regulatory Status Usage Natural occurrence Aroma- Product Name
- 3-Acetylpyridine
- CAS No.
- 350-03-8
- Chemical Name
- 3-Acetylpyridine
- Synonyms
- 3-Acetylpiridine;methylpyridylketone;1-(3-PYRIDINYL)ETHANONE;Ethanone,1-(3-pyridinyl)-;NSC 761;FEMA 3424;Imatinib-int A;3-ActylPyridine;3-ACETOPYRIDINE;3-ACETYLPYRIDNE
- CBNumber
- CB9286704
- Molecular Formula
- C7H7NO
- Formula Weight
- 121.14
- MOL File
- 350-03-8.mol
3-Acetylpyridine Property
- Melting point:
- 11-13 °C (lit.)
- Boiling point:
- 220 °C (lit.)
- Density
- 1.102 g/mL at 25 °C (lit.)
- vapor pressure
- 0.3Pa at 20℃
- FEMA
- 3424 | 3-ACETYLPYRIDINE
- refractive index
- n20/D 1.534(lit.)
- Flash point:
- 302 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Liquid
- pka
- pK1: 3.256(+1) (25°C)
- Specific Gravity
- 1.102
- color
- Clear colorless to yellow
- PH
- 6.5-7.5 (H2O, 20℃)
- Odor
- at 1.00 % in dipropylene glycol. sweet nutty dry hawthorn phenolic woody popcorn
- Odor Type
- nutty
- biological source
- synthetic
- Water Solubility
- SOLUBLE IN HOT WATER
- Merck
- 14,6116
- JECFA Number
- 1316
- BRN
- 107751
- InChIKey
- WEGYGNROSJDEIW-UHFFFAOYSA-N
- LogP
- 0.34 at 13℃
- CAS DataBase Reference
- 350-03-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanone, 1-(3-pyridinyl)-(350-03-8)
- EPA Substance Registry System
- Ethanone, 1-(3-pyridinyl)- (350-03-8)
Safety
- Hazard Codes
- T,Xi,Xn
- Risk Statements
- 25-36/38-36/37/38-20/21/22
- Safety Statements
- 45-37/39-28A-26-36
- RIDADR
- UN 2810 6.1/PG 3
- WGK Germany
- 3
- RTECS
- OB5425000
- F
- 8-10
- Hazard Note
- Irritant
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29333999
- Toxicity
- LD50 orl-rat: 46 mg/kg JACTDZ 1,681,92
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- W342408
- Product name
- 3-Acetylpyridine
- Purity
- ≥98%, FG
- Packaging
- 1 unit
- Price
- $51.87
- Updated
- 2025/07/31
- Product number
- W342408
- Product name
- 3-Acetylpyridine
- Purity
- ≥98%, FG
- Packaging
- 1 unit
- Price
- $51.87
- Updated
- 2025/07/31
- Product number
- W342408
- Product name
- 3-Acetylpyridine
- Purity
- ≥98%, FG
- Packaging
- 100g
- Price
- $113.05
- Updated
- 2025/07/31
- Product number
- W342408
- Product name
- 3-Acetylpyridine
- Purity
- ≥98%, FG
- Packaging
- 1kg
- Price
- $461.7
- Updated
- 2025/07/31
- Product number
- Y0001694
- Product name
- Imatinib impurity H
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 130 mg
- Price
- $236
- Updated
- 2025/07/31
3-Acetylpyridine Chemical Properties,Usage,Production
Identification
Description
A colorless liquid with sweet, nutty, popcorn-like aroma.
Regulatory Status
CoE: Used provisionally. Bev.: 2 ppm; Food: 3 ppm
FDA: n/a
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2004).
Usage
Reported uses (ppm): (FEMA, 1994)
Natural occurrence
Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.
Aroma
Powerful, almost choking, Cigar-tobaccotype odor, which becomes pleasant only at extreme dilution, then also more typical tobacco-like. In certain types of flower bases, substitutes for flower absolutes, etc. this chemical can produce interesting and desirable effects, Lily, Jasmin, Tuberose, etc. are types of floral fragrances that may benefit from this effect.
Chemical Properties
A colorless liquid with sweet, nutty, popcorn-like aroma
Occurrence
Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.
Uses
3-Acetylpyridine used as an intermediate for the synthesis of risedronate sodium, inhibitor of bone resorption. It is also used in perfumery.
Uses
Used in the fragrance industry and as an intermediate in the synthesis of a number of clinical drugs, including Imatinib, Mesylate, Metyrapone, Telithromycin, and Ridogrel. An analog of nicotinamide that competes for incorporation into NAD. It has been used to chemically lesion the inferior olive nucleus, thereby eliminating climbing fibers within the cerebellar cortex.
Production Methods
Produced from Ethyl nicotinate and Ethyl acetoacetate, in principle by hydrolysis of Aceto acetylpyridine.
Preparation
Dry distillation of calcium nicotinate with calcium acetate.
Definition
It is a nicotinic acidantagonist.
Safety Profile
Poison by ingestion. Moderately toxic by intraperitoneal routeMutation data reported. A flammable liquid. When heated to decomposition emits toxic fumes of NOx,. See also KETONES
Synthesis
A mixture of 22 g/h of methyl nicotinate, 57 g/h of acetic acid and 20 g/h of water was evaporated in an evaporator and passed, together with 10 l/h of nitrogen, at 400° C., over 100 ml of catalyst, which contained 2% by weight of sodium oxide, the remainder being anatase. The catalyst was prepared by impregnating 980 g of TiO2 carrier I with a solution which contained 20 g of Na2O (as aqueous NaOH). The reaction gases were then cooled and were collected in a receiver. From the discharged two-phase mixture, the organic phase was analyzed by gas chromatography. The selectivity with respect to 3-acetylpyridine was 60%.
Purification Methods
It is purified by dissolving in HCl, extracting with Et2O to remove the possible impurity of nicotinic acid, basified with NaOH and extracted with Et2O. The dried extract is filtered, evaporated and the residual oil is distilled. If the NMR spectrum indicates further impurities, then convert it to the phenylhydrazone (m 137o, yellow needles from EtOH). This is hydrolysed with HCl [Engler & Kiby Chem Ber 22 597 1889], the phenylhydrazine HCl is removed by filtration, NaNO2 is added, the solution is basified with aqueous NaOH and extracted with Et2O as before and distilled at atmospheric pressure to give 3-acetylpyridine as a colourless oil. Purification can also be achieved by shaking with 50% aqueous KOH, extracting with Et2O, drying the extract and distilling it at atmospheric pressure or in vacuo. [Kloetzel & Chubb J Am Chem Soc 79 4226 1957.] The hydrochloride has m 180-181o (from MeOH/EtOH), the picrate has m 133.8-134.8o (from H2O), and the phenylhydrazone has m 137o (129-130o)(needles, from EtOH) [Webb & Webb J Am Chem Soc 71 2285 1949]. The ketoxime has m 112o (from EtOH or *C6H6). [Strong & McElvain J Am Chem Soc 55 816 1933, Kolloff & Hunter J Am Chem Soc 63 490 1941, Beilstein 21/7 V 394.]
3-Acetylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Acetylpyridine Suppliers
- Tel
- 0519-88995800 13815038136
- Fax
- 0519-88995808
- Country
- China
- ProdList
- 62
- Advantage
- 55
- Tel
- 021-58892003
- info@qiaochem.com
- Country
- China
- ProdList
- 6059
- Advantage
- 65
- Tel
- 021-50630626 18964684208
- Fax
- 021-50563898
- kate@tajilin.com
- Country
- China
- ProdList
- 1291
- Advantage
- 58
- Tel
- 21-53530655 18930806002
- 652583651@qq.com
- Country
- China
- ProdList
- 257
- Advantage
- 58
- Tel
- 15121167815
- bangge121@sina.com
- Country
- China
- ProdList
- 259
- Advantage
- 58
- Tel
- 027-027-59106151 15172325309
- Fax
- 027-59503710
- 1400858877@qq.com
- Country
- China
- ProdList
- 9928
- Advantage
- 58
- Tel
- 86-021-50318510
- Fax
- 021-58650104
- Country
- China
- ProdList
- 69
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- sales@jonln.com
- Country
- China
- ProdList
- 1995
- Advantage
- 65
View Lastest Price from 3-Acetylpyridine manufacturers
- Product
- 3-Acetylpyridine 350-03-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-07
- Product
- 3-Acetylpyridine 350-03-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- 3-Acetylpyridine 350-03-8
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-22