4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
- Product Name
- 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
- CAS No.
- 106261-48-7
- Chemical Name
- 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
- Synonyms
- Imatinib-int G;Imatinib Imp.S;Imatinib Impurity S;Imatinib Impurity 42;Imatinib Impurity 36;Imatinib impurities5;4-(4-Methyl-1-piperazinylmethyl)benzoicAci;4-(4-Methyl-1-piperazinylMethyl)benzoic Acid;4-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID;4-(4-MethyIpiperazin-1-yImethyI)benzoic Acid
- CBNumber
- CB61449907
- Molecular Formula
- C13H18N2O2
- Formula Weight
- 234.29
- MOL File
- 106261-48-7.mol
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Property
- Melting point:
- 310-312 °C
- Boiling point:
- 377.2±32.0 °C(Predicted)
- Density
- 1.174±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.31±0.10(Predicted)
- Appearance
- White to off-white Solid
- Water Solubility
- Slightly soluble in water.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M219350
- Product name
- 4-(4-Methylpiperazin-1-ylmethyl)benzoicAcid
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- CS-D0423
- Product name
- 4-((4-Methylpiperazin-1-yl)methyl)benzoicacid
- Packaging
- 5g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CS-D0423
- Product name
- 4-((4-Methylpiperazin-1-yl)methyl)benzoicacid
- Packaging
- 10g
- Price
- $126
- Updated
- 2021/12/16
- Product number
- CS-D0423
- Product name
- 4-((4-Methylpiperazin-1-yl)methyl)benzoicacid
- Packaging
- 25g
- Price
- $253
- Updated
- 2021/12/16
- Product number
- 072050
- Product name
- 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $347
- Updated
- 2021/12/16
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Chemical Properties,Usage,Production
Uses
4-(4-Methyl-1-piperazinylmethyl)benzoic acid is used as Imatinib intermediate, as pharmaceutical intermediate.
Synthesis
728936-43-4
106261-48-7
GENERAL STEPS: Methyl 4-(4-methylpiperazin-1-ylmethyl)benzoate hydrochloride (1.25 g) was dissolved in potassium hydroxide-methanol solution (0.93 g KOH dissolved in 15 ml methanol). Water (0.75 ml) was added and the mixture was heated to reflux for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 6 with 2 M hydrochloric acid solution. the solvent was removed by evaporation and the residue was dried under vacuum. The resulting residue contained 4-(4-methylpiperazin-1-ylmethyl)benzoic acid and the inorganic salt, which could be used in the subsequent reaction without further purification, assuming 100% yield of the title compound.1H NMR (400 MHz, d6-DMSO) δ: 2.27 (s, 3H), 2.44 (bs, 2H), 3.18-3.95 (m, 8H), 7.41 ( d, 2H, J=8Hz), 7.89 (d, 2H, J=8.1Hz).
References
[1] Patent: WO2004/63191, 2004, A1. Location in patent: Page 74
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid manufacturers
- Product
- 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid 106261-48-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%HPLC
- Supply Ability
- 10tons
- Release date
- 2023-12-06
- Product
- 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid 106261-48-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20