ChemicalBook > CAS DataBase List > 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid

4-(4-Methylpiperazin-1-ylmethyl)benzoic acid

Product Name
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
CAS No.
106261-48-7
Chemical Name
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
Synonyms
Imatinib-int G;Imatinib Imp.S;Imatinib Impurity S;Imatinib Impurity 42;Imatinib Impurity 36;Imatinib impurities5;4-(4-Methyl-1-piperazinylmethyl)benzoicAci;4-(4-Methyl-1-piperazinylMethyl)benzoic Acid;4-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID;4-(4-MethyIpiperazin-1-yImethyI)benzoic Acid
CBNumber
CB61449907
Molecular Formula
C13H18N2O2
Formula Weight
234.29
MOL File
106261-48-7.mol
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4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Property

Melting point:
310-312 °C
Boiling point:
377.2±32.0 °C(Predicted)
Density 
1.174±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
4.31±0.10(Predicted)
Appearance
White to off-white Solid
Water Solubility 
Slightly soluble in water.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
M219350
Product name
4-(4-Methylpiperazin-1-ylmethyl)benzoicAcid
Packaging
250mg
Price
$40
Updated
2021/12/16
ChemScene
Product number
CS-D0423
Product name
4-((4-Methylpiperazin-1-yl)methyl)benzoicacid
Packaging
5g
Price
$84
Updated
2021/12/16
ChemScene
Product number
CS-D0423
Product name
4-((4-Methylpiperazin-1-yl)methyl)benzoicacid
Packaging
10g
Price
$126
Updated
2021/12/16
ChemScene
Product number
CS-D0423
Product name
4-((4-Methylpiperazin-1-yl)methyl)benzoicacid
Packaging
25g
Price
$253
Updated
2021/12/16
Matrix Scientific
Product number
072050
Product name
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
Purity
95+%
Packaging
1g
Price
$347
Updated
2021/12/16
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4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Chemical Properties,Usage,Production

Uses

4-(4-Methyl-1-piperazinylmethyl)benzoic acid is used as Imatinib intermediate, as pharmaceutical intermediate.

Synthesis

728936-43-4

106261-48-7

GENERAL STEPS: Methyl 4-(4-methylpiperazin-1-ylmethyl)benzoate hydrochloride (1.25 g) was dissolved in potassium hydroxide-methanol solution (0.93 g KOH dissolved in 15 ml methanol). Water (0.75 ml) was added and the mixture was heated to reflux for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 6 with 2 M hydrochloric acid solution. the solvent was removed by evaporation and the residue was dried under vacuum. The resulting residue contained 4-(4-methylpiperazin-1-ylmethyl)benzoic acid and the inorganic salt, which could be used in the subsequent reaction without further purification, assuming 100% yield of the title compound.1H NMR (400 MHz, d6-DMSO) δ: 2.27 (s, 3H), 2.44 (bs, 2H), 3.18-3.95 (m, 8H), 7.41 ( d, 2H, J=8Hz), 7.89 (d, 2H, J=8.1Hz).

References

[1] Patent: WO2004/63191, 2004, A1. Location in patent: Page 74

4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid manufacturers

Nanjing Fred Technology Co., Ltd
Product
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid 106261-48-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%HPLC
Supply Ability
10tons
Release date
2023-12-06
Career Henan Chemical Co
Product
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid 106261-48-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-20

106261-48-7, 4-(4-Methylpiperazin-1-ylmethyl)benzoic acidRelated Search:

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