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N-Desmethyl Imatinib

Product Name
N-Desmethyl Imatinib
CAS No.
404844-02-6
Chemical Name
N-Desmethyl Imatinib
Synonyms
N-DesmethyL;Imatinib EP Impurity C;CGP-74588;STI 509-00;Norimatinib;no mesylate;Imatinib Imp.F;N-methylimatinib;DesMethyl IMatinib;Imatinib Impurity F
CBNumber
CB41176575
Molecular Formula
C28H29N7O
Formula Weight
479.58
MOL File
404844-02-6.mol
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N-Desmethyl Imatinib Property

Melting point:
99-101°C
Density 
1.268±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml
form 
A lyophilized solid
pka
13.28±0.70(Predicted)
color 
Light yellow to yellow
biological source
synthetic
InChIKey
BQQYXPHRXIZMDM-UHFFFAOYSA-N
SMILES
C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)(=O)C1=CC=C(CN2CCNCC2)C=C1
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Safety

Safety Statements 
24/25
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H341Suspected of causing genetic defects

H351Suspected of causing cancer

H360May damage fertility or the unborn child

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00958
Product name
<I>N</I>-Desmethyl imatinib
Purity
&#8805;95%, research grade
Packaging
5 mg
Price
$285
Updated
2025/07/31
Sigma-Aldrich
Product number
SMB00958
Product name
<I>N</I>-Desmethyl imatinib
Purity
&#8805;95%, research grade
Packaging
25 mg
Price
$1140
Updated
2025/07/31
Cayman Chemical
Product number
16947
Product name
N-Desmethyl Imatinib
Purity
≥95%
Packaging
500μg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
16947
Product name
N-Desmethyl Imatinib
Purity
≥95%
Packaging
1mg
Price
$71
Updated
2024/03/01
Cayman Chemical
Product number
16947
Product name
N-Desmethyl Imatinib
Purity
≥95%
Packaging
5mg
Price
$275
Updated
2024/03/01
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N-Desmethyl Imatinib Chemical Properties,Usage,Production

Description

N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.

Chemical Properties

Off-White to Pale-Yellow Solid

Uses

aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes

Uses

anti-epileptic

Uses

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

Definition

ChEBI: N-Demethylated piperazine is a member of benzamides.

References

[1] DRUKER B J. Translation of the Philadelphia chromosome into therapy for CML.[J]. Blood, 2008: 4808-4817. DOI: 10.1182/blood-2008-07-077958
[2] MüLLER B A. Imatinib and its successors–how modern chemistry has changed drug development.[J]. Current pharmaceutical design, 2009, 15 2: 120-133. DOI: 10.2174/138161209787002933
[3] OBACH R S. Pharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy.[J]. Pharmacological Reviews, 2013, 65 2: 578-640. DOI: 10.1124/pr.111.005439

N-Desmethyl Imatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Desmethyl Imatinib Suppliers

Canada 2 China 187 France 1 India 7 United Kingdom 1 United States 17 Global 215
Hangzhou Yinghui Industrial Co.,Ltd
Tel
15355417531
Email
2028755477@qq.com
Country
China
ProdList
152
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
zwchem@163.com
Country
China
ProdList
617
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
Advantage
52
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View Lastest Price from N-Desmethyl Imatinib manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
N-Desmethyl imatinib 404844-02-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-13
Dideu Industries Group Limited
Product
N-Desmethyl Imatinib 404844-02-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-06
Career Henan Chemical Co
Product
N-Desmethyl Imatinib 404844-02-6
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-19

404844-02-6, N-Desmethyl ImatinibRelated Search:

Imatinib 1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine iMatinib related substance B 2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID Imatinib (Piperidine)-N-oxide 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Guanidine, N-(2-methyl-3-nitrophenyl)- Imatinib Impurity 7 N-DESMETHYL IMATINIB 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide IMatinib Para-diaMinoMethylbenzene Imatinib Meta-methyl-piperazine Impurity iMatinib related substance C 3-Acetylpyridine Imatinib EP Impurity J N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE Imatinib EP Impurity D Imatinib (Pyridine)-N-oxide

  • CGP-74588
  • N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide
  • Norimatinib
  • STI 509-00
  • Imatinib impurity 6/Imatinib EP Impurity C/N-Desmethyl Imatinib/N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide
  • Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-
  • IMATINIB METABOLITE N-DESMETHYL IMATINIB (N-DESMETHYL IMATINIB)
  • N-{4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide
  • DesMethyl IMatinib
  • DesMethyl IMatinib-d8
  • iMatinib related substance A
  • IMatinib N-DesMethyl IMpurity
  • Imatinib Impurity F
  • Imatinib metabolite N-Desmethyl Imatinib
  • Imatinib EP Impurity C
  • Imatinib EP Impurity C (N-Desmethyl Imatinib)
  • Imatinib Imp.F
  • Imatinib Impurity 6(Imatinib EP Impurity C)
  • N-Desmethyl Imatinib Impurity
  • N-DesmethyL
  • no mesylate
  • Imatinib Impurity 6（EP-C）
  • Imatinib EP Impurity C (Imatinib N-Desmethyl Impurity)
  • Imatinib Impurity C (Imatinib (Piperazine)-N1- Oxide) (crude)
  • Imatinib Impurity C (Imatinib (Piperidine)-N4- Oxide)
  • N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4...
  • Imatinib N-Desmethyl ImpurityQ: What is Imatinib N-Desmethyl Impurity Q: What is the CAS Number of Imatinib N-Desmethyl Impurity Q: What is the storage condition of Imatinib N-Desmethyl Impurity Q: What are the applications of Imatinib N-Desmethyl Impurity
  • Desmethyl imatinib D4Q: What is Desmethyl imatinib D4 Q: What is the CAS Number of Desmethyl imatinib D4 Q: What is the storage condition of Desmethyl imatinib D4 Q: What are the applications of Desmethyl imatinib D4
  • N-methylimatinib
  • N-Desmethyl lmatinib
  • N-Desmethyl imatinib, 10 mM in DMSO
  • <i>N</i>-Desmethyl imatinib
  • Inhibitor,N Desmethyl imatinib,v-Abl,PDGFR,inhibit,NDesmethyl imatinib,Drug Metabolite,Imatinib,N-Desmethyl imatinib,c-Kit
  • N-Demethylimatinib(Impurity)
  • 4-[(1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino] phenyl]benzamide
  • Imatinib Mesylate Imp C (pharmeuropa): N-4-methyl-3-4-(3-pyridinyl)-2-pyrimidinylaminophenyl-4-(1-piperazinyl methyl)benzamide
  • 404844-02-6
  • C28H29N7O
  • Metabolite Reference Standard
  • Isotopically Labeled Pharmaceutical Reference Standard
  • Intermediates & Fine Chemicals
  • Metabolites
  • Pharmaceuticals
  • Tyrosine Kinase Inhibitors
  • Various Metabolites and Impurities