ChemicalBook > CAS DataBase List > N-Desmethyl Imatinib

N-Desmethyl Imatinib

Product Name: N-Desmethyl Imatinib
CAS No.: 404844-02-6
Chemical Name: N-Desmethyl Imatinib
Synonyms: N-DesmethyL;Imatinib EP Impurity C;CGP-74588;STI 509-00;Norimatinib;no mesylate;Imatinib Imp.F;N-methylimatinib;DesMethyl IMatinib;Imatinib Impurity F
CBNumber: CB41176575
Molecular Formula: C28H29N7O
Formula Weight: 479.58
MOL File: 404844-02-6.mol

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N-Desmethyl Imatinib Property

Melting point:: 99-101°C
Density: 1.268±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml
form: A lyophilized solid
pka: 13.28±0.70(Predicted)
color: Light yellow to yellow
biological source: synthetic
InChIKey: BQQYXPHRXIZMDM-UHFFFAOYSA-N
SMILES: C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)(=O)C1=CC=C(CN2CCNCC2)C=C1

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Safety

Safety Statements: 24/25
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H341Suspected of causing genetic defects

H351Suspected of causing cancer

H360May damage fertility or the unborn child

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00958
Product name: N-Desmethyl imatinib
Purity: ≥95%, research grade
Packaging: 5 mg
Price: $285
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB00958
Product name: N-Desmethyl imatinib
Purity: ≥95%, research grade
Packaging: 25 mg
Price: $1140
Updated: 2025/07/31

Cayman Chemical

Product number: 16947
Product name: N-Desmethyl Imatinib
Purity: ≥95%
Packaging: 500μg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 16947
Product name: N-Desmethyl Imatinib
Purity: ≥95%
Packaging: 1mg
Price: $71
Updated: 2024/03/01

Cayman Chemical

Product number: 16947
Product name: N-Desmethyl Imatinib
Purity: ≥95%
Packaging: 5mg
Price: $275
Updated: 2024/03/01

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N-Desmethyl Imatinib Chemical Properties,Usage,Production

Description

N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC₅₀ = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.

Chemical Properties

Off-White to Pale-Yellow Solid

Uses

aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes

Uses

anti-epileptic

Uses

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

Definition

ChEBI: N-Demethylated piperazine is a member of benzamides.

References

[1] DRUKER B J. Translation of the Philadelphia chromosome into therapy for CML.[J]. Blood, 2008: 4808-4817. DOI: 10.1182/blood-2008-07-077958
[2] MüLLER B A. Imatinib and its successors–how modern chemistry has changed drug development.[J]. Current pharmaceutical design, 2009, 15 2: 120-133. DOI: 10.2174/138161209787002933
[3] OBACH R S. Pharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy.[J]. Pharmacological Reviews, 2013, 65 2: 578-640. DOI: 10.1124/pr.111.005439

N-Desmethyl Imatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Desmethyl Imatinib manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: N-Desmethyl imatinib 404844-02-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-13

Dideu Industries Group Limited

Product: N-Desmethyl Imatinib 404844-02-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-06

Career Henan Chemical Co

Product: N-Desmethyl Imatinib 404844-02-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-19

404844-02-6, N-Desmethyl ImatinibRelated Search:

Imatinib 1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine iMatinib related substance B 2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID Imatinib (Piperidine)-N-oxide 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Guanidine, N-(2-methyl-3-nitrophenyl)- Imatinib Impurity 7 N-DESMETHYL IMATINIB 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide IMatinib Para-diaMinoMethylbenzene Imatinib Meta-methyl-piperazine Impurity iMatinib related substance C 3-Acetylpyridine Imatinib EP Impurity J N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE Imatinib EP Impurity D Imatinib (Pyridine)-N-oxide

CGP-74588

N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide

Norimatinib

STI 509-00

Imatinib impurity 6/Imatinib EP Impurity C/N-Desmethyl Imatinib/N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide

Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-

IMATINIB METABOLITE N-DESMETHYL IMATINIB (N-DESMETHYL IMATINIB)

N-{4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide

DesMethyl IMatinib

DesMethyl IMatinib-d8

iMatinib related substance A

IMatinib N-DesMethyl IMpurity

Imatinib Impurity F

Imatinib metabolite N-Desmethyl Imatinib

Imatinib EP Impurity C

Imatinib EP Impurity C (N-Desmethyl Imatinib)

Imatinib Imp.F

Imatinib Impurity 6(Imatinib EP Impurity C)

N-Desmethyl Imatinib Impurity

N-DesmethyL

no mesylate

Imatinib Impurity 6（EP-C）

Imatinib EP Impurity C (Imatinib N-Desmethyl Impurity)

Imatinib Impurity C (Imatinib (Piperazine)-N1- Oxide) (crude)

Imatinib Impurity C (Imatinib (Piperidine)-N4- Oxide)

N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4...

Imatinib N-Desmethyl ImpurityQ: What is Imatinib N-Desmethyl Impurity Q: What is the CAS Number of Imatinib N-Desmethyl Impurity Q: What is the storage condition of Imatinib N-Desmethyl Impurity Q: What are the applications of Imatinib N-Desmethyl Impurity

Desmethyl imatinib D4Q: What is Desmethyl imatinib D4 Q: What is the CAS Number of Desmethyl imatinib D4 Q: What is the storage condition of Desmethyl imatinib D4 Q: What are the applications of Desmethyl imatinib D4

N-methylimatinib

N-Desmethyl lmatinib

N-Desmethyl imatinib, 10 mM in DMSO

N-Desmethyl imatinib

Inhibitor,N Desmethyl imatinib,v-Abl,PDGFR,inhibit,NDesmethyl imatinib,Drug Metabolite,Imatinib,N-Desmethyl imatinib,c-Kit

N-Demethylimatinib(Impurity)

4-[(1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino] phenyl]benzamide

Imatinib Mesylate Imp C (pharmeuropa): N-4-methyl-3-4-(3-pyridinyl)-2-pyrimidinylaminophenyl-4-(1-piperazinyl methyl)benzamide

404844-02-6

C28H29N7O

Metabolite Reference Standard

Isotopically Labeled Pharmaceutical Reference Standard

Intermediates & Fine Chemicals

Metabolites

Pharmaceuticals

Tyrosine Kinase Inhibitors

Various Metabolites and Impurities