ChemicalBook > CAS DataBase List > 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

Product Name
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
CAS No.
55314-16-4
Chemical Name
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
Synonyms
4G-951;Imatinib Impurity 19;Imatinib Impurity 74;Imatinib EP Impurity A;Imatinib USP Impurity A;Nilotinib??Intermediates?B;Imatinib Related Compound A;Imatinib Dimethylamino Impurity;3-Dimethylamino-1-pyridin-3-yl-pr;3-[3-(Dimethylamino)acryloyl]pyridine
CBNumber
CB1406106
Molecular Formula
C10H12N2O
Formula Weight
176.22
MOL File
55314-16-4.mol
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1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Property

Melting point:
86-88
Boiling point:
281.4±36.0 °C(Predicted)
Density 
1.070±0.06 g/cm3(Predicted)
vapor pressure 
0.049Pa at 20℃
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in chloroform and dichloromethane.
form 
powder to crystal
pka
6.19±0.70(Predicted)
color 
Light yellow to Brown
InChIKey
MZLRFUCMBQWLNV-FNORWQNLSA-N
LogP
0.26 at 20℃ and pH7.2
Surface tension
71.8mN/m at 1.008g/L and 20℃
CAS DataBase Reference
55314-16-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D3949
Product name
2-(Dimethylamino)vinyl 3-Pyridyl Ketone
Purity
>98.0%(GC)
Packaging
1g
Price
$68
Updated
2023/06/20
TCI Chemical
Product number
D3949
Product name
2-(Dimethylamino)vinyl 3-Pyridyl Ketone
Purity
>98.0%(GC)
Packaging
5g
Price
$204
Updated
2023/06/20
Alfa Aesar
Product number
H54187
Product name
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%
Packaging
5g
Price
$208
Updated
2021/12/16
Alfa Aesar
Product number
H54187
Product name
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%
Packaging
1g
Price
$53.2
Updated
2021/12/16
Alfa Aesar
Product number
H54187
Product name
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%
Packaging
250mg
Price
$17.8
Updated
2021/12/16
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1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Chemical Properties,Usage,Production

Description

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours.

Chemical Properties

Off-White Solid

Uses

Rasagiline intermediate

Uses

3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate.

Solubility in organics

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane.

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide N,N-Dimethylformamide dimethyl acetal 3-Acetylpyridine

Preparation Products

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View Lastest Price from 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
Dideu Industries Group Limited
Product
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 55314-16-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

55314-16-4, 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-oneRelated Search:

3-Dimethylaminopropylamine 4-Dimethylaminobenzaldehyde 4-Dimethylaminopyridine 2-Aminopyridine 3-Aminopyridine 4-Dimethylaminobenzoic acid N-Desmethyl Imatinib N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine 1-[2-[BIS(TERT-BUTYL)PHOSPHINO]PHENYL]-3,5-DIPHENYL-1H-PYRAZOLE 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone 1-(4,6-dibromothieno[3,4-b]thiophen-2-yl)-2-ethylhexan-1-one 1-(4,6-dibroMo-3-fluorothieno[3,4-b]thiophen-2-yl)-2ethylhexan-1-one 1-(2,3-Dichlorophenyl)piperazine hydrochloride N-DESMETHYL IMATINIB 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide Imatinib Impurity 7 Imatinib Meta-methyl-piperazine Impurity 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid

  • 2-DiMethylaMino-1-(3-pyridyl)-2-propene-1-one
  • 3-[3-(Dimethylamino)acryloyl]pyridine
  • 2-(Dimethylamino)ethenyl 3-Pyridyl Ketone 3-(Dimethylamino)-1-(3-pyridyl)-2-propen-1-one 3-[3-(Dimethylamino)acryloyl]pyridine
  • (E)-3-DIMETHYLAMINO-1-PYRIDIN-3-YL-PROPENONE
  • 3-diMethylaMino-1-(3-pyridyl)-2-propen-1-one, 3-(N,N-diMethylaMino)-1-(pyridin-3-yl)prop-2-en-1-one, 3-(diMethylaMino)-1-(pyridin-3-yl)prop-2-en-1-one
  • 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one
  • (2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one
  • (E)-3-dimethylamino-1-(3-pyridyl)prop-2-en-1-one
  • 3-dimethylamino-1-(3-pyridyl)prop-2-en-1-one
  • 3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one
  • 4G-951
  • Imatinib Dimethylamino Impurity
  • Imatinib USP Impurity A
  • 3-(DIMETHYLAMINO)-1-(3-PYRIDINYL)-2-PROPEN-1-ONE
  • 1-(3-PYRIDYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE
  • Imatinib Related Compound A
  • 3-(Dimethylamino)-1-pyridin-3-ylprop-2-en-1-one
  • 2-propen-1-one,3-（dimethylamino）-1-（3-pyridinyl）
  • 3-Dimethylamino-1-(pyridin-3-yl)propenone
  • 1-(3-PYRIDYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE 95%
  • 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one ,97%
  • 3-(Dimethylamino)-1-(3-pyridinyl)-2-propene-1-one
  • Imatinib Impurity 19
  • 2-(DiMethylaMino)vinyl 3-Pyridyl Ketone
  • Imatinib EP Impurity A
  • 2-(Dimethylamino)vinyl3-PyridylKetone&gt
  • Imatinib Dimethylamino Impurity Certified Reference Standard
  • 2-(Dimethylamino)ethenyl 3-Pyridyl Ketone
  • 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one ISO 9001：2015 REACH
  • Imatinib EP Impurity A (Imatinib Dimethylamino Impurity)
  • Nilotinib??Intermediates?B
  • 1 - (3-pyridyl) - 3 - (dimethylamino) - 2-propene-1-one
  • 3-Dimethylamino-1-pyridin-3-yl-pr
  • Imatinib Dimethylamino ImpurityQ: What is Imatinib Dimethylamino Impurity Q: What is the CAS Number of Imatinib Dimethylamino Impurity Q: What is the storage condition of Imatinib Dimethylamino Impurity Q: What are the applications of Imatinib Dimethylamino Impurity
  • 2-(Dimethylamino)vinyl 3-Pyridyl Ketone, ≥ 95.0%
  • Imatinib Impurity 74
  • 55314-16-4
  • Intermediate of Imatinib
  • Intermediates
  • Chemical Amines
  • Amines
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • Heterocycles