METHYL 4-AMINO-6-INDOLECARBOXYLATE
- Product Name
- METHYL 4-AMINO-6-INDOLECARBOXYLATE
- CAS No.
- 121561-15-7
- Chemical Name
- METHYL 4-AMINO-6-INDOLECARBOXYLATE
- Synonyms
- 4-AMINO-6-METHOXYCARBONYL INDOLE;4-AMino-6-Methylcarboxylateindole;Methyl 4-AMinoindole-6-carboxylate;METHYL 4-AMINO-6-INDOLECARBOXYLATE;Methyl 4-AMino-6-indolecarboxylate Hy;Methyl4-amino-1H-indole-6-carboxylate;4-AMINOINDOLE-6-CARBOXYLIC ACID METHYL ESTER;METHYL 4-AMINO-6-INDOLECARBOXYLATE USP/EP/BP;4-AMINO-6-INDOLE CARBOXYLIC ACID METHYL ESTER;Methyl 4-Amino-6-indolecarboxylate Hydrochloride
- CBNumber
- CB2689535
- Molecular Formula
- C10H10N2O2
- Formula Weight
- 190.2
- MOL File
- 121561-15-7.mol
METHYL 4-AMINO-6-INDOLECARBOXYLATE Property
- Melting point:
- 160-163 °C(Solv: benzene (71-43-2))
- Boiling point:
- 429.8±25.0 °C(Predicted)
- Density
- 1.339±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 17.03±0.30(Predicted)
- Appearance
- Light brown to brown Solid
- CAS DataBase Reference
- 121561-15-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M333170
- Product name
- Methyl4-Amino-1H-indole-6-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Y3318
- Product name
- Methyl4-amino-1H-indole-6-carboxylate
- Packaging
- 250mg
- Price
- $224
- Updated
- 2021/12/16
- Product number
- CHM0077587
- Product name
- METHYL 4-AMINO-6-INDOLECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- CHM0077587
- Product name
- METHYL 4-AMINO-6-INDOLECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1334.03
- Updated
- 2021/12/16
- Product number
- 132948
- Product name
- Methyl4-amino-1H-indole-6-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $2160
- Updated
- 2021/12/16
METHYL 4-AMINO-6-INDOLECARBOXYLATE Chemical Properties,Usage,Production
Uses
In the pharmaceutical field, methyl 4-amino-6-indolecarboxylate is mainly used as an organic synthesis intermediate to synthesize a variety of drug compounds, such as methyl 4-amino-6-indolecarboxylate hydrochloride, which is used in drug synthesis.
Synthesis
597562-13-5
121561-15-7
To a solution of methyl 4-[(E)-2-(dimethylamino)vinyl]-3,5-dinitrobenzoate (D200) (10 g, 34 mmol, 1 eq.) in methanol (250 ml) was added 10% palladium charcoal (50% wet, 1.0 g, 5% w/w). The reaction mixture was stirred under hydrogen atmosphere for 7 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The residue was ground with ethyl acetate/isohexane mixed solvent to afford methyl 4-amino-1H-indole-6-carboxylate (D201) (5 g, 77% yield) as a dark pink solid. Mass spectrometry analysis showed [M+H]+ = 191.0 and retention time (RT) = 1.20 min.
References
[1] Tetrahedron Letters, 2007, vol. 48, # 45, p. 7990 - 7993
[2] Patent: WO2004/50619, 2004, A1. Location in patent: Page 57
[3] Patent: WO2005/58915, 2005, A1. Location in patent: Page/Page column 18
METHYL 4-AMINO-6-INDOLECARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 4-AMINO-6-INDOLECARBOXYLATE manufacturers
- Product
- METHYL 4-AMINO-6-INDOLECARBOXYLATE 121561-15-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08