ChemicalBook > CAS DataBase List > METHYL 4-AMINO-6-INDOLECARBOXYLATE

METHYL 4-AMINO-6-INDOLECARBOXYLATE

Product Name
METHYL 4-AMINO-6-INDOLECARBOXYLATE
CAS No.
121561-15-7
Chemical Name
METHYL 4-AMINO-6-INDOLECARBOXYLATE
Synonyms
4-AMINO-6-METHOXYCARBONYL INDOLE;4-AMino-6-Methylcarboxylateindole;Methyl 4-AMinoindole-6-carboxylate;METHYL 4-AMINO-6-INDOLECARBOXYLATE;Methyl 4-AMino-6-indolecarboxylate Hy;Methyl4-amino-1H-indole-6-carboxylate;4-AMINOINDOLE-6-CARBOXYLIC ACID METHYL ESTER;METHYL 4-AMINO-6-INDOLECARBOXYLATE USP/EP/BP;4-AMINO-6-INDOLE CARBOXYLIC ACID METHYL ESTER;Methyl 4-Amino-6-indolecarboxylate Hydrochloride
CBNumber
CB2689535
Molecular Formula
C10H10N2O2
Formula Weight
190.2
MOL File
121561-15-7.mol
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METHYL 4-AMINO-6-INDOLECARBOXYLATE Property

Melting point:
160-163 °C(Solv: benzene (71-43-2))
Boiling point:
429.8±25.0 °C(Predicted)
Density 
1.339±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
17.03±0.30(Predicted)
Appearance
Light brown to brown Solid
CAS DataBase Reference
121561-15-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M333170
Product name
Methyl4-Amino-1H-indole-6-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
Y3318
Product name
Methyl4-amino-1H-indole-6-carboxylate
Packaging
250mg
Price
$224
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0077587
Product name
METHYL 4-AMINO-6-INDOLECARBOXYLATE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0077587
Product name
METHYL 4-AMINO-6-INDOLECARBOXYLATE
Purity
95.00%
Packaging
10G
Price
$1334.03
Updated
2021/12/16
Matrix Scientific
Product number
132948
Product name
Methyl4-amino-1H-indole-6-carboxylate
Purity
97%
Packaging
5g
Price
$2160
Updated
2021/12/16
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METHYL 4-AMINO-6-INDOLECARBOXYLATE Chemical Properties,Usage,Production

Uses

In the pharmaceutical field, methyl 4-amino-6-indolecarboxylate is mainly used as an organic synthesis intermediate to synthesize a variety of drug compounds, such as methyl 4-amino-6-indolecarboxylate hydrochloride, which is used in drug synthesis.

Synthesis

597562-13-5

121561-15-7

To a solution of methyl 4-[(E)-2-(dimethylamino)vinyl]-3,5-dinitrobenzoate (D200) (10 g, 34 mmol, 1 eq.) in methanol (250 ml) was added 10% palladium charcoal (50% wet, 1.0 g, 5% w/w). The reaction mixture was stirred under hydrogen atmosphere for 7 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The residue was ground with ethyl acetate/isohexane mixed solvent to afford methyl 4-amino-1H-indole-6-carboxylate (D201) (5 g, 77% yield) as a dark pink solid. Mass spectrometry analysis showed [M+H]+ = 191.0 and retention time (RT) = 1.20 min.

References

[1] Tetrahedron Letters, 2007, vol. 48, # 45, p. 7990 - 7993
[2] Patent: WO2004/50619, 2004, A1. Location in patent: Page 57
[3] Patent: WO2005/58915, 2005, A1. Location in patent: Page/Page column 18

METHYL 4-AMINO-6-INDOLECARBOXYLATE Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Cuprous iodide Palladium Nitric acid Methanol p-Toluic acid N,N-Dimethylformamide dimethyl acetal Thionyl chloride Sulfuric acid

Preparation Products

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View Lastest Price from METHYL 4-AMINO-6-INDOLECARBOXYLATE manufacturers

Career Henan Chemical Co
Product
METHYL 4-AMINO-6-INDOLECARBOXYLATE 121561-15-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

121561-15-7, METHYL 4-AMINO-6-INDOLECARBOXYLATERelated Search:

4-BENZYLOXY-6-INDOLE CARBOXYLIC ACID METHYL ESTER 4-HYDROXY-1H-INDOLE-6-CARBOXYLIC ACID METHYL ESTER 1H-Indole-6-carboxylic acid, 4-chloro-, Methyl ester 1H-Indole, 4-broMo-6-chloro- 1H-Indole-6-carboxylic acid, 4-fluoro-, Methyl ester METHYL 4-CHLORO-3-METHYLBENZOATE METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE METHYL 4-(TRIFLUOROMETHYL)NICOTINATE METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE 1H-Indole, 4-broMo-6-(phenylMethoxy)- 4-NITRO-6-INDOLECARBOXYLIC ACID METHYL ESTER METHYL 6-AMINO-4-INDOLECARBOXYLATE,Methyl 6-Amino-4-indolecarboxylate Hydrochloride Indole-6-carboxylic acid Methyl indole-6-carboxylate 6-HYDROXYMETHYLINDOLE Indole-6-carboxaldehyde 4-Aminoindole METHYL 4-AMINO-6-INDOLECARBOXYLATE

  • Methyl 4-Amino-6-indolecarboxylate Hydrochloride
  • 4-AMINO-6-METHOXYCARBONYL INDOLE
  • Methyl4-amino-1H-indole-6-carboxylate
  • 4-amino-6-indole carboxylic acid methyl ester ,95%
  • 4-amino-1H-indole-6-carboxylic acid methyl ester hydrochloride
  • 1H-Indole-6-carboxylic acid, 4-aMino-, Methyl ester
  • 4-AMino-6-Methylcarboxylateindole
  • Methyl 4-AMino-6-indolecarboxylate Hy
  • Methyl 4-AMinoindole-6-carboxylate
  • 4-AMINOINDOLE-6-CARBOXYLIC ACID METHYL ESTER
  • 4-AMINO-6-INDOLE CARBOXYLIC ACID METHYL ESTER
  • METHYL 4-AMINO-6-INDOLECARBOXYLATE
  • 1H-Indole-6-carboxylicacid,4-amino-,methylester(9CI)
  • METHYL 4-AMINO-6-INDOLECARBOXYLATE USP/EP/BP
  • 121561-15-7
  • 12156-15-7
  • Acids and Derivatives
  • Heterocycles
  • Indole/indoline/oxindole
  • Indole
  • Heterocyclic Compounds
  • AMINOACID