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N,N-Dimethylformamide dimethyl acetal

Product Name
N,N-Dimethylformamide dimethyl acetal
CAS No.
4637-24-5
Chemical Name
N,N-Dimethylformamide dimethyl acetal
Synonyms
DMF-DMA;1,1-dimethoxy-n,n-dimethyl-methanamin;DMF-DIMETHYLACETAL;1,1-DIMETHOXYTRIMETHYLAMINE;(Dimethylamino)dimethoxymethane;DIMETHYLFORMAMIDEDIMETHYLACETAL;N-(Dimethoxymethyl)dimethylamine;Dimethoxy-N,N-dimethylmethanamine;N,N-Dimethylformamide dimethyl acetal, 95% (1,1-Dimethoxytrimethylamine);METHYL-8
CBNumber
CB8178244
Molecular Formula
C5H13NO2
Formula Weight
119.16
MOL File
4637-24-5.mol
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N,N-Dimethylformamide dimethyl acetal Property

Melting point:
-85°C
Boiling point:
102-103 °C/720 mmHg (lit.)
Density 
0.897 g/mL at 25 °C (lit.)
vapor pressure 
34.5hPa at 20℃
refractive index 
n20/D 1.396(lit.)
Flash point:
45 °F
storage temp. 
Store below +30°C.
solubility 
Miscible with most organic solvents.
form 
Solid
pka
5.00±0.50(Predicted)
color 
White to off-white
PH
7 (H2O)
explosive limit
1.3-17.7%(V)
Water Solubility 
hydrolysis
Sensitive 
Moisture Sensitive
BRN 
506020
Exposure limits
ACGIH: TWA 200 ppm; STEL 250 ppm (Skin)
OSHA: TWA 200 ppm(260 mg/m3)
NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3)
LogP
0.750 (est)
CAS DataBase Reference
4637-24-5(CAS DataBase Reference)
NIST Chemistry Reference
Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5)
EPA Substance Registry System
Methanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5)
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Safety

Hazard Codes 
F,Xn,Xi
Risk Statements 
11-22-36/37/38-36/38-20-20/21/22-10-52
Safety Statements 
16-26-36/37-36/37/39-33-29-7/9
RIDADR 
UN 3271 3/PG 2
WGK Germany 
1
F 
21
Autoignition Temperature
155 °C
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29225000
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H317May cause an allergic skin reaction

H318Causes serious eye damage

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.03068
Product name
N,N-Dimethylformamide dimethyl acetal
Purity
for synthesis
Packaging
25mL
Price
$56.8
Updated
2025/07/31
Sigma-Aldrich
Product number
140732
Product name
N,N-Dimethylformamide dimethyl acetal
Purity
technical grade, 94%
Packaging
25ml
Price
$57.76
Updated
2025/07/31
Sigma-Aldrich
Product number
140732
Product name
N,N-Dimethylformamide dimethyl acetal
Purity
technical grade, 94%
Packaging
2.5l
Price
$1340
Updated
2025/07/31
Sigma-Aldrich
Product number
8.03068
Product name
N,N-Dimethylformamide dimethyl acetal
Purity
for synthesis
Packaging
1mL
Price
$34.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03068
Product name
N,N-Dimethylformamide dimethyl acetal
Purity
for synthesis
Packaging
100mL
Price
$163
Updated
2024/03/01
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N,N-Dimethylformamide dimethyl acetal Chemical Properties,Usage,Production

Chemical Properties

clear colourless liquid

Uses

N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

Uses

Used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.

Uses

1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes.

Definition

ChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica ions

General Description

Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.

Flammability and Explosibility

Highly flammable

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications

Synthesis

124-41-4

68-12-2

4637-24-5

A method for synthesizing N,N-dimethylformamide dimethyl acetal, comprising the steps of (1) heating N,N-dimethylformamide to 70°C, mixing with dimethyl sulfate in a molar ratio of 1:1 and reacting for 4 hours after the end of dropwise addition to obtain the imine complex, and then cooling to room temperature; (2) adding solid sodium methanol to 200 solvent oil, dispersing it by ultrasonication, adjusting the temperature to 25 ℃ and maintained, dropwise addition of the imine complex, the reaction for 2 hours and then filtered, the filtrate often pressure fractionation, collection of 105-108 ℃ fraction, to obtain N,N-dimethylformamide dimethyl acetal, the yield was 75.3%, purity of 97%; wherein the molar ratio of sodium methanol to the imine complex is 1:1. The synthesis of the N,N-dimethylformamide dimethyl acetal of Example 6 is the same as that of Example 2, the The difference is that the organic solvent of this embodiment is a mixed solvent oil: D40 solvent oil, D60 solvent oil and 260 solvent oil, with a volume ratio of 2:1:1, to obtain N,N-dimethylformamide dimethyl acetal with a yield of 85.4% and a purity of 97%.

References

[1] Patent: CN106083611, 2016, A. Location in patent: Paragraph 0034-0037; 0048-0049

N,N-Dimethylformamide dimethyl acetal Preparation Products And Raw materials

Raw materials

Preparation Products

(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE (1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL 1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-TERT-BUTYL 6-METHYL 3-FORMYL-1H-INDOLE-1,6-DICARBOXYLATE ETHYL 1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE 3-BROMOCHROMONE 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBONITRILE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE METHYL 4-AMINO-6-INDOLECARBOXYLATE Indole-6-carboxaldehyde ETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE (1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANAMINE ETHYL 2-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 7-Hydroxyindole 6-HYDROXYMETHYLINDOLE ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-AMINE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANAMINE 3-NITROBENZO[B]FURAN-5-OL ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONITRILE 3-NITROISONICOTINALDEHYDE (5-METHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL 2-AMINO-4-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID [1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOL-4-YL]METHANOL 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-AMINE (5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL 4-(Pyridin-3-yl)pyrimidin-2-amine 1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBONITRILE Indole-7-carboxaldehyde 4-Aminomethyl-1-methylpyrazole 5-Hydroxyindole Indole-6-carboxylic acid 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXAMIDE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE
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N,N-Dimethylformamide dimethyl acetal Suppliers

Americas 1 Austria 1 Belgium 4 Canada 7 China 578 Europe 4 France 3 Germany 15 India 78 Japan 8 Norway 1 Singapore 1 Slovakia 1 South Korea 1 Switzerland 4 United Kingdom 17 United States 57 Global 781
Acros Organics (Part of Thermo Fisher Scientific )
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Belgium
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Alkemi BVBA
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Belgium
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Acros Organics
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Belgium
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Maybridge Chemical Co., Ltd.
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View Lastest Price from N,N-Dimethylformamide dimethyl acetal manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
N,N-Dimethylformamide Dimethyl Acetal 4637-24-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-27
Shaanxi Didu New Materials Co. Ltd
Product
N,N-Dimethylformamide dimethyl acetal 4637-24-5
Price
US $1.50/g
Min. Order
1g
Purity
99.0% Min
Supply Ability
10 Tons
Release date
2025-06-25
Shaanxi Dideu New Materials Co. Ltd
Product
N,N-Dimethylformamide dimethyl acetal 4637-24-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-12

4637-24-5, N,N-Dimethylformamide dimethyl acetalRelated Search:

N,N-Dimethylformamide Dimethyl fumarate Dimethyl carbonate 1,1-Di-tert-butoxytrimethylamine Dimethyl ether ETHANE Dimethylamine Dimethyl sulfate Dimethyl sulfide Dimethyl sulfoxide N,N'-Dimethylpiperazine N,N'-Diemthyl-N-Methyllisonipecotamide N,N-Dimethylallylamine N,N-Dimethylacrylamide N,N-Dimethylglycine Acetal N,N-DIMETHYLFORMAMIDE DIBENZYL ACETAL 2-Dimethylamino-1,3-dioxolane

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