ChemicalBook > CAS DataBase List > 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Product Name
1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
CAS No.
119083-00-0
Chemical Name
1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
Synonyms
BUTTPARK 99\18-23;1-Methyl-5-(trifluoromethyl)pyrazole-4-carboxylic Acid;1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID;1H-Pyrazole-4-carboxylic acid, 1-methyl-5-(trifluoromethyl)-;1-Methyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ,97%
CBNumber
CB7377576
Molecular Formula
C6H5F3N2O2
Formula Weight
194.11
MOL File
119083-00-0.mol
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1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Property

Melting point:
121.0 to 125.0 °C
Boiling point:
285.6±40.0 °C(Predicted)
Density 
1.56±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
2.93±0.36(Predicted)
color 
White to Light yellow
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Safety

Safety Statements 
24/25
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2753
Product name
1-Methyl-5-(trifluoromethyl)pyrazole-4-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
200mg
Price
$73
Updated
2025/07/31
TCI Chemical
Product number
M2753
Product name
1-Methyl-5-(trifluoromethyl)pyrazole-4-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$220
Updated
2025/07/31
Frontier Specialty Chemicals
Product number
T11436
Product name
1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
Purity
98%
Packaging
5g
Price
$360
Updated
2021/12/16
Apolloscientific
Product number
PC905485
Product name
1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
Purity
95%
Packaging
1g
Price
$385
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
T11436
Product name
1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
Purity
98%
Packaging
1g
Price
$120
Updated
2021/12/16
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1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

231285-86-2

119083-00-0

The general procedure for the synthesis of 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid from ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate is as follows: Preparation of intermediate 65b: Ethyl 1-methyl-5-(trifluoromethyl)pyrazole-4-carboxylate (2.91 g, 13.0 mmol) was dissolved in THF (52 mL) and cooled to 0 °C. Subsequently, a solution of lithium hydroxide (627 mg, 26.1 mmol) in water (26 mL) was slowly added. The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the mixture was acidified to pH 1-2 with 1 M HCl and extracted with EtOAc (4 x 50 mL). The organic layers were combined, washed with brine (50 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford 1-methyl-5-(trifluoromethyl)pyrazole-4-carboxylic acid (2.39 g, 12.33 mmol, 94% yield) as an off-white solid. The product characterization data are as follows: 1H NMR (CDCl3, 400 MHz) δ/ppm: 8.02 (1H, s), 4.13 (3H, q, J = 2.0 Hz) Exchangeable protons. 19F NMR (CDCl3, 400 MHz) δ/ppm: -57.2. MS Method 2: RT: 1.16 min, m/z 193.0 [M-H]-.

References

[1] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00615; 00618; 00619

1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate p-Toluenesulfonic acid Acetic anhydride Triethyl orthoformate Triethylamine Methylhydrazine Sodium hydroxide N,N-Dimethylformamide dimethyl acetal

Preparation Products

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1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Suppliers

Americas 1 Belgium 1 China 56 Europe 1 Germany 1 India 2 Japan 1 Ukraine 1 United Kingdom 1 United States 9 Global 74
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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Nanjing Habo Medical Technology Co., Ltd.
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025-85760892 13376080562
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025-85766769
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sales@habotech.com
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China
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86-0571-85151182
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Syntechem Co.,Ltd
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Fax
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Japan
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320-37350700
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+32 (0)37350701
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sales@tcieurope.eu
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+1-888-520-1075 / +1-503-283-1987
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sales@tciamerica.com
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SynAsst Chemical.
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021-60343070
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021-35122006
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China
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Shanghai YuLue Chemical Co., Ltd.
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021-60345187 13671753212
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021-34702061
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View Lastest Price from 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 119083-00-0
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-07-31

119083-00-0, 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACIDRelated Search:

ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-(4-NITROPHENYL)-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID ETHYL 2-(4-NITROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID,1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ,97% 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL 1-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-(4-Phenyl-thiazol-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID ETHYL 1-(4-PHENYL-1,3-THIAZOL-2-YL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 2-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE ETHYL 1-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 4-CHLORO-2-METHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID 4-CHLORO-1-METHYL-5-TRIFLUOROMETHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID 4-CHLORO-1-METHYL-5-TRIFLUOROMETHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID HYDRAZIDE

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