ChemicalBook > CAS DataBase List > 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Product Name: 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
CAS No.: 119083-00-0
Chemical Name: 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
Synonyms: BUTTPARK 99\18-23;1-Methyl-5-(trifluoromethyl)pyrazole-4-carboxylic Acid;1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID;1H-Pyrazole-4-carboxylic acid, 1-methyl-5-(trifluoromethyl)-;1-Methyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ,97%
CBNumber: CB7377576
Molecular Formula: C6H5F3N2O2
Formula Weight: 194.11
MOL File: 119083-00-0.mol

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1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Property

Melting point:: 121.0 to 125.0 °C
Boiling point:: 285.6±40.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 2.93±0.36(Predicted)
color: White to Light yellow

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Safety

Safety Statements: 24/25
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2753
Product name: 1-Methyl-5-(trifluoromethyl)pyrazole-4-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $73
Updated: 2025/07/31

TCI Chemical

Product number: M2753
Product name: 1-Methyl-5-(trifluoromethyl)pyrazole-4-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $220
Updated: 2025/07/31

Frontier Specialty Chemicals

Product number: T11436
Product name: 1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
Purity: 98%
Packaging: 5g
Price: $360
Updated: 2021/12/16

Apolloscientific

Product number: PC905485
Product name: 1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
Purity: 95%
Packaging: 1g
Price: $385
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: T11436
Product name: 1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
Purity: 98%
Packaging: 1g
Price: $120
Updated: 2021/12/16

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1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

231285-86-2

119083-00-0

The general procedure for the synthesis of 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid from ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate is as follows: Preparation of intermediate 65b: Ethyl 1-methyl-5-(trifluoromethyl)pyrazole-4-carboxylate (2.91 g, 13.0 mmol) was dissolved in THF (52 mL) and cooled to 0 °C. Subsequently, a solution of lithium hydroxide (627 mg, 26.1 mmol) in water (26 mL) was slowly added. The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the mixture was acidified to pH 1-2 with 1 M HCl and extracted with EtOAc (4 x 50 mL). The organic layers were combined, washed with brine (50 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford 1-methyl-5-(trifluoromethyl)pyrazole-4-carboxylic acid (2.39 g, 12.33 mmol, 94% yield) as an off-white solid. The product characterization data are as follows: 1H NMR (CDCl3, 400 MHz) δ/ppm: 8.02 (1H, s), 4.13 (3H, q, J = 2.0 Hz) Exchangeable protons. 19F NMR (CDCl3, 400 MHz) δ/ppm: -57.2. MS Method 2: RT: 1.16 min, m/z 193.0 [M-H]-.

References

[1] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00615; 00618; 00619

1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate p-Toluenesulfonic acid Acetic anhydride Triethyl orthoformate Triethylamine Methylhydrazine Sodium hydroxide N,N-Dimethylformamide dimethyl acetal

Preparation Products

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View Lastest Price from 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 119083-00-0
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-31

119083-00-0, 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACIDRelated Search:

1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

BUTTPARK 99\18-23

1-Methyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ,97%

1-Methyl-5-(trifluoromethyl)pyrazole-4-carboxylic Acid

1H-Pyrazole-4-carboxylic acid, 1-methyl-5-(trifluoromethyl)-

119083-00-0

Building Blocks

Pyrazole