4-Methyl-3-nitrophenol

Product Name: 4-Methyl-3-nitrophenol
CAS No.: 2042-14-0
Chemical Name: 4-Methyl-3-nitrophenol
Synonyms: 3-NITR;NSC 41205;Nitropcresol;NITRO-4-CRESOL;-3-nitrophenoL;3-NITRO-P-CRESOL;p-Cresol, 3-nitro-;TIMTEC-BB SBB008513;3-Nitro-p-cresol>3-NITRO-4-METHYLPHENOL
CBNumber: CB9185900
Molecular Formula: C7H7NO3
Formula Weight: 153.14
MOL File: 2042-14-0.mol

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4-Methyl-3-nitrophenol Property

Melting point:: 78-81 °C (lit.)
Boiling point:: 266.03°C (rough estimate)
Density: 1.2744 (estimate)
vapor pressure: 0.084Pa at 25℃
refractive index: 1.5744 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Ethyl Acetate, Methanol
form: Powder
pka: 8.66±0.10(Predicted)
color: Pale Yellow Crystalline
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C7H7NO3/c1-5-2-3-6(9)4-7(5)8(10)11/h2-4,9H,1H3
InChIKey: BQEXDUKMTVYBRK-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(C)C([N+]([O-])=O)=C1
LogP: 2.18 at 25℃
CAS DataBase Reference: 2042-14-0(CAS DataBase Reference)
NIST Chemistry Reference: 4-Methyl-3-nitrophenol(2042-14-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-36
RIDADR: 2446
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29089990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 139815
Product name: 4-Methyl-3-nitrophenol
Purity: 98%
Packaging: 25g
Price: $76
Updated: 2025/07/31

TCI Chemical

Product number: N0210
Product name: 3-Nitro-p-cresol
Purity: >98.0%(T)
Packaging: 5g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: N0210
Product name: 3-Nitro-p-cresol
Purity: >98.0%(T)
Packaging: 25g
Price: $53
Updated: 2025/07/31

TRC

Product number: N496625
Product name: 3-Nitro-4-methylphenol
Packaging: 1g
Price: $50
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK210436
Product name: 4-Methyl-3-nitrophenol
Purity: 98%
Packaging: 5g
Price: $32
Updated: 2021/12/16

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4-Methyl-3-nitrophenol Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Crystalline Solid

Uses

3-Nitro-4-methylphenol (cas# 2042-14-0) is a compound useful in organic synthesis.

Synthesis Reference(s)

Synthesis, p. 735, 1986 DOI: 10.1055/s-1986-31759

Synthesis

119-32-4

2042-14-0

General procedure for the synthesis of 4-methyl-3-nitrophenol from 4-methyl-3-nitroaniline: 4-methyl-3-nitroaniline (200 mg, 1.31 mmol) was dissolved in a 3:1 mixture of H2SO4-H2O. The resulting mixture was heated to 100 °C and kept for 30 min. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and NaNO2 solution was added slowly and dropwise. After the dropwise addition was completed, the reaction was continued for 1 hour, after which the mixture was heated to reflux. After the reaction was complete, the reaction mixture was extracted several times with EtOAc, the organic phases were combined and dried with anhydrous Na2SO4, and subsequently concentrated. The crude product was purified by fast column chromatography (eluent ratio: petroleum ether-ethyl acetate 9:1) to give a yellow solid in 70% yield. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.48 (s, 1H), 7.17 (d, J = 8.4 Hz, 1H), 7.01 (dd, J = 8.4, 2.4 Hz, 1H), 5.84 (s, 1H), 2.48 (s, 3H) ppm.

References

[1] Chemistry - A European Journal, 2009, vol. 15, # 12, p. 2742 - 2746
[2] Patent: WO2016/128541, 2016, A1. Location in patent: Page/Page column 92; 93
[3] Patent: WO2017/162834, 2017, A1. Location in patent: Page/Page column 85
[4] Justus Liebigs Annalen der Chemie, 1882, vol. 215, p. 83
[5] Chemische Berichte, 1882, vol. 15, p. 2992

4-Methyl-3-nitrophenol Preparation Products And Raw materials

Raw materials

Preparation Products

6-Hydroxyindole 4-BENZYLOXY-2-NITROTOLUENE 6-Methoxy-1H-indole-3-carboxylic acid 4-Methyl-3-nitroanisole 6-Benzyloxyindole 6-Methoxyindole 5-Methoxy-2-methylaniline 6-Methoxy-1H-indole-3-carbaldehyde

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4-Methyl-3-nitrophenol Suppliers

Americas 1 Belgium 1 Canada 1 China 237 Europe 3 Germany 3 India 6 Japan 3 Slovakia 1 Switzerland 4 Ukraine 1 United Kingdom 11 United States 34 Global 306

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View Lastest Price from 4-Methyl-3-nitrophenol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Methyl-3-nitrophenol 2042-14-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: 1000kg
Release date: 2022-09-29

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Methyl-3-nitrophenol 2042-14-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-12

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Methyl-3-nitrophenol 2042-14-0
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-21

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Oxygen Compounds

Phenols

Organic Building Blocks

Building Blocks

Pyrimidines

Phenoles and thiophenoles

Aromatics Compounds

Naphthyridine,Quinoline

Aromatics

Aromatic Phenols

Intermediates of Dyes and Pigments