5-Methoxy-2-methylaniline

Product Name: 5-Methoxy-2-methylaniline
CAS No.: 50868-72-9
Chemical Name: 5-Methoxy-2-methylaniline
Synonyms: NSC 229308;Einecs 256-816-4;6-METHYL-M-ANISIDINE;5-methoxy-o-toluidine;5-Methoxy-2-methylani;LABOTEST-BB LTBB000645;3-Amino-4-methylanisole;5-Methoxy-2-Methylanilin;2-amino-4-methoxytoluene;3-Methoxy-6-methylaniline
CBNumber: CB3401640
Molecular Formula: C8H11NO
Formula Weight: 137.18
MOL File: 50868-72-9.mol

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5-Methoxy-2-methylaniline Property

Melting point:: 43-46 °C (lit.)
Boiling point:: 253°C(lit.)
Density: 1.0630 (rough estimate)
refractive index: 1.5647 (estimate)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Powder
pka: 4.03±0.10(Predicted)
color: Off-white to pale grey to yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C8H11NO/c1-6-3-4-7(10-2)5-8(6)9/h3-5H,9H2,1-2H3
InChIKey: RPJXLEZOFUNGNZ-UHFFFAOYSA-N
SMILES: C1(N)=CC(OC)=CC=C1C

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: 6.1
HS Code: 29222990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 335436
Product name: 5-Methoxy-2-methylaniline
Purity: 97%
Packaging: 1g
Price: $44.8
Updated: 2023/06/20

Sigma-Aldrich

Product number: 335436
Product name: 5-Methoxy-2-methylaniline
Purity: 97%
Packaging: 5g
Price: $196
Updated: 2023/06/20

TCI Chemical

Product number: M3009
Product name: 5-Methoxy-2-methylaniline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $47
Updated: 2024/03/01

TCI Chemical

Product number: M3009
Product name: 5-Methoxy-2-methylaniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $186
Updated: 2024/03/01

TRC

Product number: M336795
Product name: 5-Methoxy-2-methylaniline
Packaging: 1g
Price: $45
Updated: 2021/12/16

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5-Methoxy-2-methylaniline Chemical Properties,Usage,Production

Chemical Properties

White to gray to tan crystalline powder

Uses

5-Methoxy-2-methylaniline was used in the preparation of N-(5-methoxy-2-methylphenyl)acetamide.

Uses

5-Methoxy-2-methylaniline was used in the preparation of N-(5-methoxy-2-methylphenyl)acetamide.

Synthesis

17484-36-5

50868-72-9

Under nitrogen atmosphere, 4-methoxy-1-methyl-3-nitrobenzene (18.0 g, 108 mmol) was dissolved in 160 mL of 1,2-dimethoxyethane (DME), followed by the addition of 10% Pd/C catalyst (0.9 g). Hydrazine hydrate (16.17 g, 323 mmol) was slowly added dropwise to the above solution. The reaction mixture was heated to reflux and stirred continuously for 4 hours. After that, 3 mL of hydrazine hydrate was added additionally and stirring was continued under reflux conditions for 2 days. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to remove the solvent to give the crude product 5-methoxy-2-methylaniline as a yellow oil. After further vacuum drying, the product solidified to a pale yellow solid in a yield of 14.8 g (100% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 6.94 (d, J = 7.53 Hz, 1H), 6.28 (d, J = 7.53 Hz, 1H), 6.26 (s, 1H), 3.78 (s, 3H), 3.5 (br, 1H), 2.10 (s, 3H), 1.6 (br, 1H).

References

[1] Patent: WO2009/117097, 2009, A1. Location in patent: Page/Page column 70-71
[2] Tetrahedron, 2018, vol. 74, # 12, p. 1294 - 1306
[3] Justus Liebigs Annalen der Chemie, 1882, vol. 215, p. 83
[4] Journal of the Chemical Society, 1929, p. 870
[5] Journal of the Chemical Society, 1925, vol. 127, p. 995

5-Methoxy-2-methylaniline Preparation Products And Raw materials

Raw materials

Acetonitrile Potassium carbonate Glycine Palladium Palladium on activated carbon 5% Pd 4-Methyl-3-nitrophenol Dimethyl sulfate

Preparation Products

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5-Methoxy-2-methylaniline Suppliers

Americas 1 China 134 Europe 1 Germany 1 India 8 Japan 1 Switzerland 1 United Kingdom 1 United States 10 Global 158

Shanghai Harvest Chemical Industrial Co., Ltd.

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Energy Chemical

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Beijing Eternalchem Co,. Ltd.

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Shanghai Ennopharm Co., Ltd.

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View Lastest Price from 5-Methoxy-2-methylaniline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Methoxy-2-methylaniline 50868-72-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-07

Career Henan Chemical Co

Product: 5-Methoxy-2-methylaniline 50868-72-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

50868-72-9, 5-Methoxy-2-methylanilineRelated Search:

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5-Methoxy-2-Methylaniline, 97% 1GR

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NSC 229308

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5-Methoxy-2-Methylanilin

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50868-72-9

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