Ethyl 4-hydroxypyrimidine-5-carboxylate

Product Name: Ethyl 4-hydroxypyrimidine-5-carboxylate
CAS No.: 4786-52-1
Chemical Name: Ethyl 4-hydroxypyrimidine-5-carboxylate
Synonyms: 7-chloroisoquinolin-1(2H)-one;ethyl 6-oxo-1H-pyrimidine-5-carboxylate;ETHYL 4-HYDROXYPYRIMIDINE-5-CARBOXYLATE;4-hydroxy-5-pyrimidinecarboxylicaciethylester;Ethyl 1,4-dihydro-4-oxo-5-pyrimidinecarboxylate;6-Hydroxypyrimidine-5-carboxylic acid ethyl ester;6-keto-1H-pyrimidine-5-carboxylic acid ethyl ester;Ethyl 6-oxo-1,6-dihydropyrimidine-5-carboxylate LR;4-HYDROXY-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER;6-OXO-1,6-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
CBNumber: CB9680218
Molecular Formula: C7H8N2O3
Formula Weight: 168.15
MOL File: 4786-52-1.mol

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Ethyl 4-hydroxypyrimidine-5-carboxylate Property

Melting point:: 185-186 °C
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 7.70±0.40(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C7H8N2O3/c1-2-12-7(11)5-3-8-4-9-6(5)10/h3-4H,2H2,1H3,(H,8,9,10)
InChIKey: PLMIZYMXBHSARX-UHFFFAOYSA-N
SMILES: C1NC(=O)C(C(OCC)=O)=CN=1

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Safety

HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E945508
Product name: Ethyl4-hydroxypyrimidine-5-carboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: E945508
Product name: Ethyl4-hydroxypyrimidine-5-carboxylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: E945508
Product name: Ethyl4-hydroxypyrimidine-5-carboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 449282
Product name: Ethyl 4-hydroxypyrimidine-5-carboxylate
Packaging: 100mg
Price: $305
Updated: 2021/12/16

Matrix Scientific

Product number: 066325
Product name: Ethyl 4-hydroxypyrimidine-5-carboxylate
Packaging: 5g
Price: $325
Updated: 2021/12/16

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Ethyl 4-hydroxypyrimidine-5-carboxylate Chemical Properties,Usage,Production

Uses

7-Chloroisoquinolin-1(2H)-one acts as a reagent for the preparation, SAR of methoxyisoquinoline derivative and discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection. Synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5-methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-HT3 antagonists.

Synthesis

Ethyl 4-hydroxy-5-pyrimidinecarboxylate was prepared as follows:

Add 1.6g (70mmol) of sodium metal to 50mL of anhydrous ethanol, wait for the reaction to be complete, ice-water bath cooled to 0??C, add 7.3g (70mmol) formamidine acetate, followed by the slow dropwise addition of 15.1g (70mmol) diethyl ethoxymethylidene malonate , the reaction was continued at 0 ??C for 3 h. 1.6 g (70 mmol) of sodium metal dissolved in 50 mL of anhydrous ethanol was cooled to 0 ??C and added dropwise to the above reaction solution. After the reaction at room temperature overnight, the majority of the ethanol was removed to give a yellow solid. It was added to 100mL of water, heated until dissolved, and when cooled, 100mL of ether was added, stirred thoroughly, and the ether was separated to remove the raw material that had not reacted completely. Continue to heat to dissolve, use concentrated hydrochloric acid to adjust the pH of the solution to 2 ~ 3, after cooling, precipitated light yellow solid, filtered, vacuum dried, and finally obtained 9.4g of light yellow solid, the yield was 80%.

Ethyl 4-hydroxypyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 4-hydroxypyrimidine-5-carboxylate Suppliers

China 127 India 1 United Kingdom 2 United States 22 Global 152

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View Lastest Price from Ethyl 4-hydroxypyrimidine-5-carboxylate manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Ethyl-5-fluoropyrimidine 4786-52-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

Dideu Industries Group Limited

Product: Ethyl 4-hydroxypyrimidine-5-carboxylate 4786-52-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-09

Career Henan Chemical Co

Product: Ethyl 4-hydroxypyrimidine-5-carboxylate 4786-52-1
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

4786-52-1, Ethyl 4-hydroxypyrimidine-5-carboxylateRelated Search:

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6-Hydroxypyrimidine-5-carboxylic acid ethyl ester

4-hydroxy-5-pyrimidinecarboxylicaciethylester

ETHYL 4-HYDROXYPYRIMIDINE-5-CARBOXYLATE

6-OXO-1,6-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

4-HYDROXY-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

5-Pyrimidinecarboxylic acid, 1,4-dihydro-4-oxo-, ethyl ester

Ethyl 6-oxo-1,6-dihydropyrimidine-5-carboxylate LR

Ethyl 1,4-dihydro-4-oxo-5-pyrimidinecarboxylate

6-keto-1H-pyrimidine-5-carboxylic acid ethyl ester

ethyl 6-oxo-1H-pyrimidine-5-carboxylate

5-Pyrimidinecarboxylic acid, 1,6-dihydro-6-oxo-, ethyl ester

7-chloroisoquinolin-1(2H)-one

4-Hydroxy-pyrimidine-5-carboxylic acid ethyl ester (HCl salt)

Ethyl 4-hydroxypyrimidine-5-carboxylate ISO 9001：2015 REACH

Ethyl 6-oxo-1,6-dihydro-pyrimidine-5-carboxylate, CAS 4786-52-1

4786-52-1

pharmacetical

Heterocycle-Pyrimidine series

CMLLYL