Isoquinolin-6-ol
- Product Name
- Isoquinolin-6-ol
- CAS No.
- 7651-82-3
- Chemical Name
- Isoquinolin-6-ol
- Synonyms
- 6-Isoquinolinol;isoquinolin-6-ol;Einecs 231-612-8;Isoquinoline-6-ol;2H-Isoquinolin-6-one;6-HYDROXYISOQUINOLINE;6-Hydroxyisoquinoline96%;Isoquinolin-6-ol ISO 9001：2015 REACH;6-Hydroxyisoquinoline, 98% (Custom work);Isoquinolin-6-ol, 6-Hydroxy-2-azanaphthalene
- CBNumber
- CB8197713
- Molecular Formula
- C9H7NO
- Formula Weight
- 145.16
- MOL File
- 7651-82-3.mol
Isoquinolin-6-ol Property
- Melting point:
- 220 °C
- Boiling point:
- 332.1±15.0 °C(Predicted)
- Density
- 1.260±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 9.15±0.10(Predicted)
- color
- Pale yellow
- InChI
- InChI=1S/C9H7NO/c11-9-2-1-8-6-10-4-3-7(8)5-9/h1-6,11H
- InChIKey
- GPVPDRHTRGTSIH-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=C(O)C=C2)C=CN=1
- CAS DataBase Reference
- 7651-82-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- H942915
- Product name
- 6-Hydroxyisoquinoline
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 4H01-1-P4
- Product name
- 6-Hydroxyisoquinoline
- Purity
- 98%
- Packaging
- 250mg
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 4H01-1-P4
- Product name
- 6-Hydroxyisoquinoline
- Purity
- 98%
- Packaging
- 500mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 069893
- Product name
- 6-Hydroxyisoquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 4H01-1-P4
- Product name
- 6-Hydroxyisoquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
Isoquinolin-6-ol Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
6-Hydroxyisoquinoline is used in proteomics research such as in preparation of isoquinoline derivatives which act as protease inhibitors against trypsin. It was also used as a reagent in the study of a novel series of compounds that act as Wnt signaling pathway inhibitors and obtained by scaffold hybridization strategy from two known porcupine inhibitor classes.
Synthesis
52986-70-6
7651-82-3
(c) 6-Methoxyisoquinoline (16 g, 0.1 mol) was mixed with 48% aqueous hydrobromic acid (600 mL) and heated to reflux for 6 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water (H2O) and the pH was adjusted to alkaline with solid sodium carbonate (Na2CO3). The precipitated solid product was collected by filtration and recrystallized with isopropanol to give the final 6-hydroxyisoquinoline (12 g, 82% yield) with a melting point of 205°C. Literature reports a melting point of 218°-220°C (Lit.* 220°C).
References
[1] Patent: US4812573, 1989, A
[2] Patent: WO2004/43904, 2004, A1. Location in patent: Page 59
[3] Patent: WO2004/43931, 2004, A1. Location in patent: Page 36-37
[4] Journal of the American Chemical Society, 1947, vol. 69, p. 1944
[5] European Journal of Organic Chemistry, 2003, # 9, p. 1681 - 1686
Isoquinolin-6-ol Preparation Products And Raw materials
Raw materials
Preparation Products
Isoquinolin-6-ol Suppliers
- Tel
- --
- Fax
- --
- info@activate-scientific.com
- Country
- Germany
- ProdList
- 2856
- Advantage
- 61
View Lastest Price from Isoquinolin-6-ol manufacturers
- Product
- Isoquinolin-6-ol 7651-82-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-08-08
- Product
- Isoquinolin-6-ol 7651-82-3
- Price
- US $5.50/KG
- Min. Order
- 1IU
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-14