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Hydroxyapatite

Product Name
Hydroxyapatite
CAS No.
1306-06-5
Chemical Name
Hydroxyapatite
Synonyms
HA;TRICALCIUM PHOSPHATE;CALCIUM HYDROXYAPATITE;HYDROXYLAPATITE;TRIBASIC CALCIUM PHOSPHATE;Apatite HAP;DURAPATITE;CALCIUM PHOSPHATE HYDROXIDE;BONE ASH;APATITE HAP, MONOCLINIC
CBNumber
CB2131094
Molecular Formula
Ca5HO13P3
Formula Weight
502.31
MOL File
1306-06-5.mol
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Hydroxyapatite Property

Melting point:
1100 °C(lit.)
Density 
3.076 g/cm3(Temp: 18 °C)
storage temp. 
2-8°C
solubility 
H2O: 0.3 mg/mL, clear, colorless
form 
solid
color 
White
Water Solubility 
insoluble H2O [MER06]
Merck 
13,3500
CAS DataBase Reference
1306-06-5(CAS DataBase Reference)
EPA Substance Registry System
Hydroxylapatite (Ca5(OH)(PO4)3) (1306-06-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
MY8434000
3-10
TSCA 
Yes
HS Code 
28352600
Hazardous Substances Data
1306-06-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
391947
Product name
Hydroxylapatite, fast flow
Packaging
100g
Price
$701
Updated
2024/03/01
Sigma-Aldrich
Product number
21223
Product name
Hydroxyapatite
Purity
purum p.a., ≥90% (as Ca3(PO4)2, KT)
Packaging
1kg
Price
$194
Updated
2024/03/01
Sigma-Aldrich
Product number
04238
Product name
Hydroxyapatite
Purity
≥90% (calculated on glowed substance)
Packaging
1kg
Price
$136
Updated
2024/03/01
Alfa Aesar
Product number
J60076
Product name
Hydroxylapatite, fast flow
Packaging
10g
Price
$85.65
Updated
2024/03/01
Alfa Aesar
Product number
J60076
Product name
Hydroxylapatite, fast flow
Packaging
50g
Price
$373
Updated
2024/03/01
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Hydroxyapatite Chemical Properties,Usage,Production

Description

Calcium hydroxyapatite has a unique structure in that it is conductive along the hydroxide channels. OH- ions lie at (1/4/,1/4,1/4) and (3/4/,3/4,3/4) on the c-axis and charge-carrying protons are responsible for the observed conductivities in M10(PO4)6(OH)2. The H+ migration between the electroattractive ion (O2) to give molecular H2O in matrix channels carries charge and the resulting conductivity.
The unit cell consists of two triangular prismatic subcells forming a rhombic prism with vertical sides. There are two horizontal mirror planes at the OH levels of 1/4 and 3/4 of the c-axis. In addition, there is a center of inversion exactly in the center of each vertical face of each subcell.

Chemical Properties

Tricalcium phosphate is an odorless and tasteless powder that is stable in air. Tribasic calcium phosphate consists of a variable mixture of calcium phosphates having the approximate composition of 10CaO·3P2O5·H2O.

Chemical Properties

white powder

Occurrence

Occurs in nature as the minerals: oxydapatit, voelicherite, whitlockite.

Uses

Hydroxyapatite and tricalcium phosphate are bioactive ceramic materials and they find applications as bone grafts, fillers and coating material for metal implants.

Uses

Prosthetic aid (artificial bone and teeth).

Uses

In the 1970s, it was found that sintered calcium hydroxyapatite, (Ca10(PO4)6(OH)2 (abbreviated as CaHap), possessed excellent biocompatibility and nontoxicity with femur and mandible bones. Since then, CaHap has been used as a biomaterial for artificial teeth and bones and as a filler for cements and polymers. Today, bone fillers made of CaHap are widely used in the medical and dental fields. In the 1980s, it was found that sintered CaHap has a good compatibility with skin tissues. Hence, percutaneous devices based on CaHap have been developed and applications have included continuous ambulatory peritoneal dialysis and intravenous hyperalimentation systems, blood pressure measurement and blood access for nutrition. Recently, many researchers have studied the chemistry of apatites, particularly CaHap, and have found various applications, such as artificial teeth and bones, ion exchangers, adsorbents for chromatography to separate proteins and enzymes, catalysts, ionic conductors, temperature and gas sensors, etc.

Preparation

The technical product is also known as “bone ash.” Commercial preparation from phosphate rock.

Definition

The major constituent of bone and tooth mineral. It is finely divided, crystalline, nonstoichiometric material rich in surface ions (carbonate, magnesium, citrate), which are readily replaced by fluoride ion, thus affording protection to the teeth.

brand name

Alveograf (Sterling Winthrop); Periograf (Sterling Winthrop).

General Description

Bone and tooth implant materials have been prepared from polycrystalline hydroxyapatite. The compressive, flexural, torsional and dynamic torsional strengths of polycrystalline hydroxyapatite were investigated. Electrophoretic deposition of hydroxyapatite on to flat titanium plate material has been studied.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Modified hydroxylapatite, also frequently called hydroxyapatite and better known as bone mineral, makes up ~50% of our bones. Hydroxylapatite is a natural form of the mineral calcium apatite, whose formula is usually denoted as Ca10(PO4)6(OH)2. Modifications of hydroxylapatite can also be found in the teeth, and a chemically identical substance is often used as filler for replacement of bones, and so on. Nevertheless, despite similar or identical chemical compositions, the response of the body to these compounds can be quite different.

Hydroxyapatite Preparation Products And Raw materials

Raw materials

Preparation Products

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Hydroxyapatite Suppliers

Wuhan penglei Biotechnology Co., Ltd
Tel
13554168242
Email
445014292@qq.com
Country
China
ProdList
285
Advantage
58
Wuhan lanabai Pharmaceutical Chemical Co., Ltd
Tel
15307151931
Fax
QQ-2355680
Email
2355680@qq.com
Country
China
ProdList
8237
Advantage
58
Xi'AnTongZeBiotechCo.,Ltd
Tel
+86-18591971926 +86-18591971926
Email
3516471159@qq.com
Country
China
ProdList
154
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18739
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
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View Lastest Price from Hydroxyapatite manufacturers

Hebei Dangtong Import and export Co LTD
Product
Hydroxyapatite 1306-06-5
Price
US $70.00-60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20Tons
Release date
2023-10-09
Shaanxi Haibo Biotechnology Co., Ltd
Product
Hydroxyapatite 1306-06-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-12-05
Henan Fengda Chemical Co., Ltd
Product
Hydroxyapatite 1306-06-5
Price
US $35.00-1.40/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-02

1306-06-5, HydroxyapatiteRelated Search:


  • CALCIUM PHOSPHATE, HYDROXIDE PURIFIED
  • Hydroxyapatite: (Calcium hydroxyapatite)
  • Calcium phosphate hydroxide, Durapatite, Hydroxylapatite
  • CALCIUM PHOSPHATE, HYDROXIDE REAGENT
  • Apatite HAP
  • Hydroxyapatite,Calcium hydroxyphosphate, Calcium phosphate tribasic, HAp, Hydroxylapatite
  • Hydroxylapatite, for analysis 25GR
  • apatite,hydroxy
  • Bonedust
  • calciumorthophosphate,basic
  • hydroxylapatite(ca5(oh)(po4)3)
  • hydroxylapatite(ca5(oh)(po4)3)(9ci)
  • hydroxylapatite[ca5(oh)(po4)3]
  • monite
  • Food Grade Hydroxyapatite, HAP
  • Medical Grade Hydroxyapatite, HAP
  • Hydroxya
  • Hydroxylapatite, 99%, Globular, 80 μm
  • Hydroxylapatite,globular(HCa5O5P)
  • Hydroxylapatite,needle-like(HCa5O5P)
  • Hydroxylapatite,short rod-like(HCa5O5P)
  • hydroxylapatite high resolution
  • Hydroxylapatite, 97.5%, Needle-like, 20 nm
  • Hydroxylapatite, 99%, Fiber-like, Width: 10 nm
  • Hydroxylapatite, 99%, Needle-like, 20 nm
  • Hydroxylapatite, 99%, Rod-like, Width:30 nm
  • pentacalciummonohydroxyorthophosphate
  • periograf
  • supertite10
  • Hyaluronic Acid, HA
  • Hydroxylapatit
  • HYDROXYLAPATITE REAGENT GRADE POWDER
  • Hydroxylapatite, for analysis
  • Tribasic calcium phosphate, NF, Fine GranularTribasic calcium phosphate, NF, Fine GranularTribasic calcium phosphate, NF, Fine GranularTribasic calcium phosphate, NF, Fine Granular
  • CALCIUM PHOSPHATE, HYDROXIDE, REAGENTCALCIUM PHOSPHATE, HYDROXIDE, REAGENTCALCIUM PHOSPHATE, HYDROXIDE, REAGENTCALCIUM PHOSPHATE, HYDROXIDE, REAGENT
  • CALCIUM PHOSPHATE HYDROXIDE
  • CALCIUM HYDROXIDE PHOSPHATE
  • CALCIUM HYDROXYAPATITE
  • BONE ASH
  • BEEF BONE POWDER
  • APATITE HAP, MONOCLINIC
  • HA, BOVINE
  • HA
  • HYALURONIC ACID HUMAN
  • HYALURONIC ACID, BOVINE
  • HYDROXYLAPATITE
  • HYDROXYLAPATITE CERAMIC
  • HYDROXYAPATITE
  • DURAPATITE
  • COPOLY(BETA-GLUCURONIC ACID-[1->3]-BETA-N-ACETYLGLUCOSAMINE-[1->4]
  • Select-HA? Hyaluronan
  • Hydroxyapatite Microspheres
  • Hydroxyapatite powder, 10 mum, >=100 m2/g
  • Hydroxyapatite powder, 5 mum, surface area >=100 m2/g
  • HAw
  • ALTERNATING COPOLY: BETA-GLUCURONIC ACID - [1->5] - BETA - N - ACETYL GLUCOSAMINE - [1->4]
  • TRICALCIUM PHOSPHATE
  • TRIBASIC CALCIUM PHOSPHATE