Description References
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Glycolic acid

Description References
Product Name
Glycolic acid
CAS No.
79-14-1
Chemical Name
Glycolic acid
Synonyms
2-HYDROXYACETIC ACID;GLYCOLATE;glycolic;HYDROXYACETIC ACID;HOCH2COOH;GLYCOLLIC ACID;Glycolic acid 70%;GLYCOLIC ACID SIGMAULTRA;glycolate (hydroxyacetate);GLYCOLIC ACID, HIGH PURITY, 70 WT.% SOLU TION IN WATER
CBNumber
CB9463563
Molecular Formula
C2H4O3
Formula Weight
76.05
MOL File
79-14-1.mol
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Glycolic acid Property

Melting point:
75-80 °C (lit.)
Boiling point:
112 °C
Density 
1.25 g/mL at 25 °C
vapor pressure 
10.8 hPa (80 °C)
refractive index 
n20/D 1.424
Flash point:
112°C
storage temp. 
Store below +30°C.
solubility 
H2O: 0.1 g/mL, clear
pka
3.83(at 25℃)
form 
Solution
color 
White to off-white
PH
2 (50g/l, H2O, 20℃)
Odor
at 100.00 %. odorless very mild buttery
Odor Type
buttery
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,4498
BRN 
1209322
Stability:
Stable. Incompatible with bases, oxidizing agents and reducing agents.
InChIKey
AEMRFAOFKBGASW-UHFFFAOYSA-N
LogP
-1.07 at 20℃
CAS DataBase Reference
79-14-1(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, hydroxy-(79-14-1)
EPA Substance Registry System
Glycolic acid (79-14-1)
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Safety

Hazard Codes 
C
Risk Statements 
34-22-20
Safety Statements 
26-36/37/39-45-23
RIDADR 
UN 3265 8/PG 3
WGK Germany 
1
RTECS 
MC5250000
TSCA 
Yes
HS Code 
2918 19 98
HazardClass 
8
PackingGroup 
II
Hazardous Substances Data
79-14-1(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 1.95 g/kg, H. F. Smyth et al., J. Ind. Hyg. Toxicol. 23, 259 (1941)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H332Harmful if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14662
Product name
Glycolic acid
Purity
(70% solution in water) special quality
Packaging
1L
Price
$224
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14662
Product name
Glycolic acid
Purity
(70% solution in water) special quality
Packaging
5L
Price
$873
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14662
Product name
Glycolic acid
Purity
(70% solution in water) special quality
Packaging
25L
Price
$2550
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14186
Product name
Glycolic acid
Purity
(70% solution in water) for synthesis
Packaging
1L
Price
$79.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.04104
Product name
Glycolic acid
Purity
for synthesis
Packaging
100g
Price
$127
Updated
2024/03/01
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Glycolic acid Chemical Properties,Usage,Production

Description

Glycolic acid is the smallest alpha-hydroxy acid (AHA). It is mainly supplemented to various skin-care products to improve the skin’s appearance and texture. It can also reduce wrinkles, acne scarring, and hyperpigmentation. In textile industry, it can be used as a dyeing and tanning agent. It can also be used as a flavoring agent in food processing, and as a skin care agent in the pharmaceutical industry. It can also be added into emulsion polymers, solvents and ink additives to improve flow properties and impart gloss. Moreover, it is a useful intermediate for organic synthesis including oxidative-reduction, esterification and long chain polymerization.

References

Bhatia, A. C., and F. Jimenez. "Rapid treatment of mild acne with a novel skin care system containing 1% salicylic acid, 10% buffered glycolic acid, and botanical ingredients." Journal of Drugs in Dermatology Jdd13.6(2014):678-83.
https://en.wikipedia.org/wiki/Glycolic_acid
https://pubchem.ncbi.nlm.nih.gov/compound/glycolic_acid#section=Top

Chemical Properties

Glycolic acid, CH20HCOOH, also known as hydroxyacetic acid, is composed of colorless deliquescent leaflets that decompose at approximately 78° C (172 OF). It is soluble in water,alcohol,and ether.Glycolic acid is used in dyeing, tanning, electropolishing,and in foodstuffs. It is produced by oxidizing glycol with dilute nitric acid.

Uses

In the processing of textiles, leather, and metals; in pH control, and wherever a cheap organic acid is needed, e.g. in the manufacture of adhesives, in copper brightening, decontamination cleaning, dyeing, electroplating, in pickling, cleaning and chemical milling of metals.

Uses

glycolic acid (hydroxyacetic acid) reduces corenocyte cohesion and corneum layer thickening where an excess buildup of dead skin cells can be associated with many common skin problems, such as acne, dry and severely dry skin, and wrinkles. glycolic acid acts by dissolving the internal cellular cement responsible for abnormal keratinization, facilitating the sloughing of dead skin cells. It also improves skin hydration by enhancing moisture uptake as well as increasing the skin’s ability to bind water. This occurs in the cellular cement through an activation of glycolic acid and the skin’s own hyaluronic acid content. Hyaluronic acid is known to retain an impressive amount of moisture and this capacity is enhanced by glycolic acid. As a result, the skin’s own ability to raise its moisture content is increased. glycolic acid is the simplest alpha hydroxyacid (AHA). It is also the AHA that scientists and formulators believe has greater penetration potential largely due to its smaller molecular weight. It is mildly irritating to the skin and mucous membranes if the formulation contains a high glycolic acid concentration and/ or a low pH. glycolic acid proves beneficial for acne-prone skin as it helps keep pores clear of excess keratinocytes. It is also used for diminishing the signs of age spots, as well as actinic keratosis. However, glycolic acid is most popularly employed in anti-aging cosmetics because of its hydrating, moisturizing, and skin-normalizing abilities, leading to a reduction in the appearance of fine lines and wrinkles. Regardless of the G skin type, glycolic acid use is associated with softer, smoother, healthier, and younger looking skin. glycolic acid is naturally found in sugarcane but synthetic versions are most often used in cosmetic formulations.

Definition

ChEBI: A 2-hydroxy monocarboxylic acid that is acetic acid where the methyl group has been hydroxylated.

Preparation

There are different preparation methods to synthesize glycolic acid. However, the most common method is the catalyzed reaction of formaldehyde with synthesis gas, which costs less. It can be prepared when chloroacetic acid reacts with sodium hydroxide and undergoes re-acidification. Electrolytic reduction of oxalic acid also could synthesize this compound. Glycolic acid can be separated from natural sources like sugarcane, sugar beets, pineapple, cantaloupe, and unripe grapes. It can be prepared by hydrolyzing the cyanohydrin that is derived from formaldehyde.

benefits

Glycolic acid addresses skin issues by exfoliating dead skin cells that accumulate on the surface of the epidermis and contribute to dull, discolored, and uneven looking skin.

Flammability and Explosibility

Non flammable

Side effects

Common side effects of Glycolic acid include dry skin, erythema (skin redness), burning sensation, itching, skin irritation, and skin rash. It can make the skin more sensitive in the sunlight, hence always use sunscreen and protective clothing before you step outdoors.

Source

Glycolic acid is widespread in nature and can be separated from natural sources like sugarcane, sugar beets, pineapple, cantaloupe, and unripe grapes.

Purification Methods

Crystallise it from diethyl ether. [Beilstein 3 IV 571.]

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Glycolic acid Suppliers

Jiangsu Raien Environmental Protection Technology Co., Ltd
Tel
0513-66017680 16651336298
Email
16651336298@163.com
Country
China
ProdList
1923
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
551-65418679 15837135945
Fax
0551-65418697
Email
info@tnjchem.com
Country
China
ProdList
1889
Advantage
62
Kono Chem Co., Ltd
Tel
029-86107037-8014 18292830413
Email
info@konochemical.com
Country
China
ProdList
536
Advantage
58
Yangzhou modier Electronic Materials Co., Ltd
Tel
0514-82098883; 13761402923
Email
market@modeltemol.com
Country
China
ProdList
871
Advantage
58
Shaanxi Pioneer Biotech Co.,Ltd
Tel
18629309720
Email
sales@pioneerbiotech.com
Country
China
ProdList
209
Advantage
58
Yancheng Green Chemicals Co.,Ltd.
Tel
25-25-86655873 02586655873
Email
marketing@royal-chem.com
Country
China
ProdList
75
Advantage
58
Xi'an Bright Herb Biotech Co., Ltd.
Tel
17391987094 18729593924
Email
1273976566@qq.com
Country
China
ProdList
148
Advantage
58
Heze Jinbang Biotechnology Co., Ltd
Tel
13396212269 18765019857
Email
903286878@qq.com
Country
China
ProdList
51
Advantage
58
Jiaxing Jilat Chemical Co. LTD
Tel
0573-82813639 15157377625
Fax
0573-82813637
Email
sales@jlightchem.com
Country
China
ProdList
141
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from Glycolic acid manufacturers

Dorne Chemical Technology co. LTD
Product
Glycolic acid 79-14-1
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000kg
Release date
2024-03-26
Jinan Finer Chemical Co., Ltd
Product
Glycolic acid 79-14-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000mt
Release date
2021-11-22
Hebei Yime New Material Technology Co., Ltd.
Product
Glycolic acid 79-14-1
Price
US $55.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
1000kg
Release date
2021-05-19

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