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Diethyl acetamidomalonate

Product Name
Diethyl acetamidomalonate
CAS No.
1068-90-2
Chemical Name
Diethyl acetamidomalonate
Synonyms
Diethyl 2-acetamidomalonate;ETHYL ACETAMIDOMALONATE;DIETHYL ACETAMINOMALONATE;ACETAMIDO DIETHYL MALONATE;diethyl 2-acetamidopropanedioate;ACETAMIDOMALONIC ACID DIETHYL ESTER;2-ACETYLAMINO-MALONIC ACID DIETHYL ESTER;2-(Acetylamino)propanedioic acid diethyl ester;AA-DEM;NSC 7645
CBNumber
CB3491359
Molecular Formula
C9H15NO5
Formula Weight
217.22
MOL File
1068-90-2.mol
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Diethyl acetamidomalonate Property

Melting point:
95-98 °C (lit.)
Boiling point:
185 °C/20 mmHg (lit.)
Density 
1.2850 (rough estimate)
refractive index 
1.4640 (estimate)
Flash point:
185°C/20mm
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
11.93±0.59(Predicted)
form 
Crystalline Powder
color 
White to light yellow
Water Solubility 
Soluble in chloroform and methanol. Slightly soluble in water.
BRN 
783883
InChIKey
ISOLMABRZPQKOV-UHFFFAOYSA-N
CAS DataBase Reference
1068-90-2(CAS DataBase Reference)
NIST Chemistry Reference
Propanedioic acid, (acetylamino)-, diethyl ester(1068-90-2)
EPA Substance Registry System
Propanedioic acid, 2-(acetylamino)-, 1,3-diethyl ester (1068-90-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-36/37/38
Safety Statements 
39-36-26-44
WGK Germany 
3
RTECS 
OO0360000
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29241900
Hazardous Substances Data
1068-90-2(Hazardous Substances Data)
Toxicity
eye-rbt 500 mg/24H MLD 28ZPAK -,130,72
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D84601
Product name
Diethyl acetamidomalonate
Purity
98%
Packaging
25g
Price
$41.6
Updated
2024/03/01
Sigma-Aldrich
Product number
D84601
Product name
Diethyl acetamidomalonate
Purity
98%
Packaging
100g
Price
$63.4
Updated
2024/03/01
TCI Chemical
Product number
A0015
Product name
Diethyl Acetamidomalonate
Purity
>98.0%(GC)
Packaging
25g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
A0015
Product name
Diethyl Acetamidomalonate
Purity
>98.0%(GC)
Packaging
100g
Price
$37
Updated
2024/03/01
Alfa Aesar
Product number
A14048
Product name
Diethyl acetamidomalonate, 98+%
Packaging
25g
Price
$20.65
Updated
2024/03/01
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Diethyl acetamidomalonate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Diethyl 2-Acetamidomalonate, is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin analogues as potential heat shock protein 90 inhibitors. It is also used as a important intermediates in syntheses of vitamins B1 and B6, barbiturates, non-steroidal anti-inflammatory agents, other numerous pharmaceuticals.

Safety Profile

An eye irritant. When heated todecomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the ester from *benzene/pet ether. [Beilstein 4 III 2993.]

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Diethyl acetamidomalonate Suppliers

Jinan Daen Pharmaceutical Technology Co., Ltd
Tel
0531-68657833 15553112864
Fax
-
Email
2098511197@qq.com
Country
China
ProdList
219
Advantage
58
yxinchem
Tel
+86-0710-4323688 +86-18071785587
Fax
15502706050
Email
market@yxinchem.com
Country
China
ProdList
1022
Advantage
58
Shanghai yongzeng technology co., LTD
Tel
021-021-65281118 15921781258
Fax
021-6528 2963
Email
sales@yongzchem.com
Country
China
ProdList
64
Advantage
58
Hubei Xinkang Pharmaceutical Chemical Co., Ltd
Tel
027-027-59308705 18871579363
Fax
027-59308705
Email
1248680011@qq.com
Country
China
ProdList
9984
Advantage
58
Taizhou Huaxi Technology Co. LTD
Tel
0576-89164227 13105618688
Fax
0576-89164227
Email
18323010@qq.com
Country
China
ProdList
38
Advantage
58
Hubei Nordina Biotechnology Co., Ltd.
Tel
19371278702
Email
n13164103386@163.com
Country
China
ProdList
2292
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
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View Lastest Price from Diethyl acetamidomalonate manufacturers

Changde Changlian Chemical Co., Ltd.
Product
Diethyl acetamidomalonate 1068-90-2
Price
US $0.00/KG/Tin
Min. Order
20KG
Purity
>98%
Supply Ability
100 tons
Release date
2020-07-15
Ningxia Jinhua Chemical Co.,Ltd
Product
Diethyl acetamidomalonate 1068-90-2
Price
US $0.00/Kg/Drum
Min. Order
20KG
Purity
>98%
Supply Ability
100 tons
Release date
2020-07-15
hebei hongtan Biotechnology Co., Ltd
Product
Diethyl acetamidomalonate 1068-90-2
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-03-22

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