ChemicalBook > CAS DataBase List > Diethyl acetamidomalonate

Diethyl acetamidomalonate

Product Name
Diethyl acetamidomalonate
CAS No.
1068-90-2
Chemical Name
Diethyl acetamidomalonate
Synonyms
Diethyl 2-acetamidomalonate;ETHYL ACETAMIDOMALONATE;DIETHYL ACETAMINOMALONATE;ACETAMIDO DIETHYL MALONATE;diethyl 2-acetamidopropanedioate;ACETAMIDOMALONIC ACID DIETHYL ESTER;2-ACETYLAMINO-MALONIC ACID DIETHYL ESTER;2-(Acetylamino)propanedioic acid diethyl ester;AA-DEM;NSC 7645
CBNumber
CB3491359
Molecular Formula
C9H15NO5
Formula Weight
217.22
MOL File
1068-90-2.mol
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Diethyl acetamidomalonate Property

Melting point:
95-98 °C (lit.)
Boiling point:
185 °C/20 mmHg (lit.)
Density 
1.2850 (rough estimate)
refractive index 
1.4640 (estimate)
Flash point:
185°C/20mm
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
11.93±0.59(Predicted)
form 
Crystalline Powder
color 
White to light yellow
Water Solubility 
Soluble in chloroform and methanol. Slightly soluble in water.
BRN 
783883
InChIKey
ISOLMABRZPQKOV-UHFFFAOYSA-N
CAS DataBase Reference
1068-90-2(CAS DataBase Reference)
NIST Chemistry Reference
Propanedioic acid, (acetylamino)-, diethyl ester(1068-90-2)
EPA Substance Registry System
Propanedioic acid, 2-(acetylamino)-, 1,3-diethyl ester (1068-90-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-36/37/38
Safety Statements 
39-36-26-44
WGK Germany 
3
RTECS 
OO0360000
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29241900
Hazardous Substances Data
1068-90-2(Hazardous Substances Data)
Toxicity
eye-rbt 500 mg/24H MLD 28ZPAK -,130,72
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D84601
Product name
Diethyl acetamidomalonate
Purity
98%
Packaging
25g
Price
$41.6
Updated
2024/03/01
Sigma-Aldrich
Product number
D84601
Product name
Diethyl acetamidomalonate
Purity
98%
Packaging
100g
Price
$63.4
Updated
2024/03/01
TCI Chemical
Product number
A0015
Product name
Diethyl Acetamidomalonate
Purity
>98.0%(GC)
Packaging
25g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
A0015
Product name
Diethyl Acetamidomalonate
Purity
>98.0%(GC)
Packaging
100g
Price
$37
Updated
2024/03/01
Alfa Aesar
Product number
A14048
Product name
Diethyl acetamidomalonate, 98+%
Packaging
25g
Price
$20.65
Updated
2024/03/01
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Diethyl acetamidomalonate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Diethyl 2-Acetamidomalonate, is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin analogues as potential heat shock protein 90 inhibitors. It is also used as a important intermediates in syntheses of vitamins B1 and B6, barbiturates, non-steroidal anti-inflammatory agents, other numerous pharmaceuticals.

Safety Profile

An eye irritant. When heated todecomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the ester from *benzene/pet ether. [Beilstein 4 III 2993.]

Diethyl acetamidomalonate Preparation Products And Raw materials

Raw materials

Preparation Products

DIETHYL 2-(ACETAMINDO)-2-(2-METHYL-5-NITROBENZYL)MALONATE Diethyl(acetylamino)((2-((bis(2-hydroxyethyl)amino)methyl)-5-nitrophenyl)methyl)propanedioate Rebamipide DIETHYL 2-(ACETAMIDO)-2-(2-(BROMOMETHYL)-5-NITROBENZYL)MALONATE Diethyl(acetylamino)((2-((bis(2-chloroethyl)amino)methyl)-5-nitrophenyl)methyl)propanedioate
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Diethyl acetamidomalonate Suppliers

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View Lastest Price from Diethyl acetamidomalonate manufacturers

Changde Changlian Chemical Co., Ltd.
Product
Diethyl acetamidomalonate 1068-90-2
Price
US $0.00/KG/Tin
Min. Order
20KG
Purity
>98%
Supply Ability
100 tons
Release date
2020-07-15
Ningxia Jinhua Chemical Co.,Ltd
Product
Diethyl acetamidomalonate 1068-90-2
Price
US $0.00/Kg/Drum
Min. Order
20KG
Purity
>98%
Supply Ability
100 tons
Release date
2020-07-15
hebei hongtan Biotechnology Co., Ltd
Product
Diethyl acetamidomalonate 1068-90-2
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-03-22

1068-90-2, Diethyl acetamidomalonateRelated Search:

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