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BOC-TIC-OH

Product Name
BOC-TIC-OH
CAS No.
78879-20-6
Chemical Name
BOC-TIC-OH
Synonyms
Boc-Tic;BOC-L-TIC;BOC-TIC-OH;BOC-L-TIC-OH;Boc-Tic-OH, >=98%;RARECHEM BK PT 0083;BOC-TIC-OH USP/EP/BP;Boc-Tic-OH >=97.0% (TLC);(Tert-Butoxy)Carbonyl Tic-OH;Boc-L-Tetrahydroisoquinoline-3-COOH
CBNumber
CB4750051
Molecular Formula
C15H19NO4
Formula Weight
277.32
MOL File
78879-20-6.mol
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BOC-TIC-OH Property

Melting point:
125-126.5 °C
Boiling point:
420.18°C (rough estimate)
Density 
1.1311 (rough estimate)
refractive index 
1.5080 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
soluble in Methanol
form 
Solid
pka
3.88±0.20(Predicted)
color 
White to off-white
optical activity
[α]20/D +19.0±1.5°, c = 0.7% in methanol
BRN 
4297114
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Safety

Hazard Codes 
Xi
Safety Statements 
22-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4501
Product name
(S)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$84
Updated
2025/07/31
TCI Chemical
Product number
B4501
Product name
(S)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$249
Updated
2025/07/31
Biosynth Carbosynth
Product number
FB55897
Product name
Boc-(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Packaging
250g
Price
$275
Updated
2021/12/16
AK Scientific
Product number
Q696
Product name
N-Boc-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid
Packaging
250g
Price
$306
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB55897
Product name
Boc-(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Packaging
100g
Price
$120
Updated
2021/12/16
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BOC-TIC-OH Chemical Properties,Usage,Production

Chemical Properties

white to light beige powder

Uses

Boc-Tic-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Synthesis

24424-99-5

74163-81-8

115962-35-1

The general procedure for the synthesis of (R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid from di-tert-butyl dicarbonate and (S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid was as follows: (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (50.0 g, 282 mmol) was suspended in 1,4-dioxane ( 1000 mL) and water (500 mL) in a solvent mixture with vigorous stirring. Sodium bicarbonate (47.4 g, 564 mmol) and di-tert-butyl dicarbonate (67.7 g, 310 mmol) were subsequently added and the reaction mixture was stirred continuously at room temperature for 6 days. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was dissolved in water (2000 mL). A 30% w/v aqueous solution of sodium bisulfate monohydrate (300 mL) was added and extracted with chloroform (3 x 1000 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the target product (R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (90.0 g, quantitative yield) as a thick slurry.Results of LCMS analysis: retention time 3.64 min; mass spectrometry data m/z 178.1 [M-Boc + 2H]+ ; m/ z 276.1 [M-H]-.

References

[1] Patent: WO2017/153513, 2017, A1. Location in patent: Page/Page column 78
[2] Patent: WO2017/153515, 2017, A1. Location in patent: Page/Page column 62
[3] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 44; 47
[4] Patent: WO2017/153519, 2017, A1. Location in patent: Page/Page column 56; 59
[5] Tetrahedron Letters, 2001, vol. 42, # 43, p. 7559 - 7561

BOC-TIC-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-TIC-OH Suppliers

Americas 1 Belgium 3 China 131 Europe 3 France 2 Germany 6 India 5 Japan 6 Switzerland 5 United Kingdom 14 United States 54 Global 230
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Shanghai HC Biotech Co., Ltd
Tel
021-20227858
Fax
+86-21-20227857
Email
sale@hcbiotech.com.cn
Country
China
ProdList
1095
Advantage
55
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Suzhou haiyu Biochem Industrial Co., LTD
Tel
512-68097639 18013585858
Fax
0512-
Email
744942877@qq.com
Country
China
ProdList
915
Advantage
62
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
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View Lastest Price from BOC-TIC-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-Tic-OH 78879-20-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-11-16
Career Henan Chemical Co
Product
BOC-TIC-OH 78879-20-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

78879-20-6, BOC-TIC-OHRelated Search:

BOC-L-TYROSINE ETHYL ESTER Boc-L-serine methyl ester Boc-L-Tyrosine methyl ester BOC-VAL-NH2 BOC-SER-OH N-Boc-L-tert-Leucine N-Boc-L-valine BOC-L-TYR-OL BOC-TRP-OME Boc-L-Threonine BOC-L-Tyrosine O-(2-Azido-4,6-O-benzylidene-2-deoxy-alpha-D-galactopyranosyl)-N-Fmoc-L-serine tert-Butyl Ester 5,6,7,8-TETRAHYDROISOQUINOLINE L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 1,2,3,4-TETRAHYDROISOQUINOLINE H-TIC-OH

  • Boc-(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid98+%
  • (S)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic A cid,99%e.e.
  • (Tert-Butoxy)Carbonyl Tic-OH
  • Boc-Tic
  • N-Boc-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, 98%
  • N-T-BUTOXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • (S)-()-N-BOC-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID
  • (S)-(+)-N-BOC-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID
  • (S)-N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • RARECHEM BK PT 0083
  • (S)-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • (S)-(+)-2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID
  • (S)-3,4-DIHYDRO-1H-ISOQUINOLINE-2,3-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER
  • BOC-1,2,3,4-L-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • BOC-(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • Boc-Tic-OH >=97.0% (TLC)
  • Boc-Tic-OH, >=98%
  • (3S)-2-[(2-methylpropan-2-yl)oxy-oxomethyl]-3,4-dihydro-1H-isoquinoline-3-carboxylate
  • N-tert-Butoxycarbonyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • BOC-L-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • BOC-L-TIC
  • BOC-L-TIC-OH
  • BOC-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • BOC-TIC-OH
  • BOC-(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • 2,3(1H)-ISOQUINOLINEDICARBOXYLIC ACID, 3,4-DIHYDRO-,2-(1,1-DIMETHYLETHYL) ESTER, (3S)-
  • (3S)-2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • (S)-(+)-2-(Tertutoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
  • (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-BOC protected
  • (S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • N-T-BUTYLOXYCARBONYL-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • N-BOC-L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid,99%
  • Boc-(S)-1,2,3,4-tetrahydroisoquinoline-line-3-carboxylic acid
  • N-1-BOC-L-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
  • N-1-T-BOC-L-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
  • N-ALPHA-T-BOC-L-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
  • N-BOC-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • N-TERT-BUTYLOXYCARBONYL-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
  • N-Boc-L-1,2,3,4-Tetrahydroisoquinoline-3-carboxyli
  • N-T-boc-L-1,2,3,4-tetrahydroiso-*quinoline-3-carb
  • Boc-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic
  • (3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-BOC protected
  • Boc-L-Tetrahydroisoquinoline-3-COOH
  • Boc-Tic-OH(Boc-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid)
  • N-Boc-L-1,2,3,4-Tetrahydroisoquinoline-3-carboxyli acid
  • Boc-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylicaci
  • BOC-TIC-OH USP/EP/BP
  • Boc-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid, 98%mim
  • 78879-20-6
  • 78879-20-9
  • 78879-20-8
  • 78879-20-7
  • C15H19NO4
  • Peptide Synthesis
  • Others
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis