Boc-L-serine methyl ester

Product Name: Boc-L-serine methyl ester
CAS No.: 2766-43-0
Chemical Name: Boc-L-serine methyl ester
Synonyms: methyl (tert-butoxycarbonyl)-L-serinate;BOC-SER-OME;(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-hydroxypropanoate;Boc-L-Ser-OMe;N-BOC-L-SERINE METHYL ESTER;Boc-Ser-Me;BOC-SERINE-OME;DL-(4-NO2)-Phe;Boc-DL-Ser.oMe;Boc-Ser-OMe 95%
CBNumber: CB5454347
Molecular Formula: C9H17NO5
Formula Weight: 219.24
MOL File: 2766-43-0.mol

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Boc-L-serine methyl ester Property

alpha: -18 º (c=5 in methanol)
Boiling point:: 354.3±32.0 °C(Predicted)
Density: 1.082 g/mL at 25 °C(lit.)
refractive index: n20/D 1.452(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 10.70±0.46(Predicted)
form: Liquid or Oil
color: Colorless to yellow
optical activity: [α]20/D 18°, c = 5 in methanol
Water Solubility: Slightly soluble in water.
BRN: 3545389
InChIKey: SANNKFASHWONFD-LURJTMIESA-N
CAS DataBase Reference: 2766-43-0(CAS DataBase Reference)

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Safety

Safety Statements: 23-24/25
WGK Germany: 3
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 410489
Product name: Boc-Ser-OMe
Purity: 95%
Packaging: 1g
Price: $38
Updated: 2025/07/31

Sigma-Aldrich

Product number: 410489
Product name: Boc-Ser-OMe
Purity: 95%
Packaging: 10g
Price: $152.79
Updated: 2025/07/31

TCI Chemical

Product number: B2073
Product name: N-(tert-Butoxycarbonyl)-L-serine Methyl Ester
Purity: >95.0%(HPLC)(N)
Packaging: 5g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: B2073
Product name: N-(tert-Butoxycarbonyl)-L-serine Methyl Ester
Purity: >95.0%(HPLC)(N)
Packaging: 25g
Price: $59
Updated: 2025/07/31

TRC

Product number: B690850
Product name: N-(tert-Butoxycarbonyl)-L-serine Methyl Ester
Packaging: 25g
Price: $275
Updated: 2021/12/16

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Boc-L-serine methyl ester Chemical Properties,Usage,Production

Chemical Properties

Liquid

Uses

N-tert-Butoxycarbonyl-L-serine Methyl Ester is an amino acid derivative used in the preparation of Tn antigen, L-glutamic acid p-nitroanilide analogs and new biomedical polymers having Serine and Threonine side groups.

Uses

Boc-L-serine methyl ester is a derivative of L-Serine Methyl Ester Hydrochloride (S271005) derivative. Boc-L-serine methyl ester is an amino acid derivative used in the preparation of Tn antigen, L-glutamic acid p-nitroanilide analogs and new biomedical polymers having Serine and Threonine side groups.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

5680-80-8

2766-43-0

General procedure for the synthesis of Boc-L-serine methyl ester from di-tert-butyl dicarbonate and L-serine methyl ester hydrochloride: crude L-serine methyl ester hydrochloride (0.29 mol) was suspended in dichloromethane (200 mL), followed by the addition of triethylamine (79 mL, 0.57 mol) and di-tert-butyl dicarbonate (68 g, 0.31 mol) to the mixture. The reaction was carried out at 0°C. After removal of the cooling bath, the reaction mixture was stirred at room temperature overnight and then diluted with methyl tert-butyl ether (300 mL). The mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by fast column chromatography on silica gel to afford Boc-L-serine methyl ester (60 g, 94% yield) as a colorless oil.

References

[1] European Journal of Organic Chemistry, 2000, # 1, p. 115 - 124
[2] Organic Letters, 2003, vol. 5, # 24, p. 4599 - 4602
[3] Journal of Organic Chemistry, 2015, vol. 80, # 1, p. 40 - 51
[4] Journal of the American Chemical Society, 2016, vol. 138, # 43, p. 14218 - 14221
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 19, p. 3089 - 3093

Boc-L-serine methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-4-BOC-MORPHOLINE-3-CARBOXYLIC ACID

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Boc-L-serine methyl ester Suppliers

Americas 1 Canada 1 China 252 Europe 1 Germany 6 India 32 Japan 3 South Korea 1 Switzerland 4 United Kingdom 8 United States 43 Global 352

Nantong puyue biomedical Co., Ltd

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Energy Chemical

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View Lastest Price from Boc-L-serine methyl ester manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Ser-OMe 2766-43-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-20

Sichuan Jiaying Lai Technology Co.,LTD

Product: Boc-Ser-OMe 2766-43-0
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-21

Career Henan Chemical Co

Product: Boc-L-serine methyl ester 2766-43-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-16

2766-43-0, Boc-L-serine methyl esterRelated Search:

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Boc-L-serine methyl ester, N-(tert-Butoxycarbonyl)-L-serine methyl ester

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(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-hydroxypropanoate

Boc-Ser-OMe 95%

L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

Boc-L-Ser-OMe

methyl (2S)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate

Tert-butyl (S)-1-(methoxycarbonyl)-2-hydroxyethylcarbamate

(S)-Boc-2-amino-3-hydroxypropionic acid methyl ester

Boc-L-serine methyl ester≥ 98% (HPLC)

Boc-L-β-hydroxyalanine methyl ester

N-Boc-L-serine Methyl Ester,99%e.e.

Boc-DL-Ser.oMe

N-(tert-Butoxycarbonyl)-L-serine Methyl Ester , 95.0%(LC&N

N-(tert-Butoxycarbonyl)-3-hydroxy-L-alanine methyl ester

BOC-L-Serine methyleester

(Tert-Butoxy)Carbonyl Ser-OMe (Syrup)

methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxypropanoate

Boc-Ser-OMe, 95%, for synthesis

N-(tert-Butoxycarbonyl)-L-serine Methyl Ester &gt

methyl (tert-butoxycarbonyl)-L-serinate

Tert butoxycarbonyl-l-serine methyl ester

BOC-L-Serine Methyl Ester extrapure, 98%

N-[(1,1-Dimethylethoxy)carbonyl]-L-serine methyl ester

Boc-L-Ser-OMe-OH

N-Boc-L-serine methyl ester, 98%

2766-43-0

HOCH2CHNHCO2CCH33CO2CH3

Serine

Specialty Synthesis

Peptide Synthesis

Amino Acid Derivatives

Boc-Amino Acids

Amino Acids (N-Protected)

Protected & Labeled Amino Acids

Boc-Amino Acids

Boc-Amino acid series

Amino Acid Derivatives

Serine [Ser, S]

Boc-Amino Acids and Derivative