ChemicalBook > CAS DataBase List > Boc-L-serine methyl ester

Boc-L-serine methyl ester

Product Name
Boc-L-serine methyl ester
CAS No.
2766-43-0
Chemical Name
Boc-L-serine methyl ester
Synonyms
methyl (tert-butoxycarbonyl)-L-serinate;BOC-SER-OME;(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-hydroxypropanoate;Boc-L-Ser-OMe;N-BOC-L-SERINE METHYL ESTER;Boc-Ser-Me;BOC-SERINE-OME;DL-(4-NO2)-Phe;Boc-DL-Ser.oMe;Boc-Ser-OMe 95%
CBNumber
CB5454347
Molecular Formula
C9H17NO5
Formula Weight
219.24
MOL File
2766-43-0.mol
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Boc-L-serine methyl ester Property

alpha 
-18 º (c=5 in methanol)
Boiling point:
354.3±32.0 °C(Predicted)
Density 
1.082 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.452(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
10.70±0.46(Predicted)
form 
Liquid or Oil
color 
Colorless to yellow
optical activity
[α]20/D 18°, c = 5 in methanol
Water Solubility 
Slightly soluble in water.
BRN 
3545389
InChIKey
SANNKFASHWONFD-LURJTMIESA-N
CAS DataBase Reference
2766-43-0(CAS DataBase Reference)
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Safety

Safety Statements 
23-24/25
WGK Germany 
3
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
410489
Product name
Boc-Ser-OMe
Purity
95%
Packaging
1g
Price
$38
Updated
2025/07/31
Sigma-Aldrich
Product number
410489
Product name
Boc-Ser-OMe
Purity
95%
Packaging
10g
Price
$152.79
Updated
2025/07/31
TCI Chemical
Product number
B2073
Product name
N-(tert-Butoxycarbonyl)-L-serine Methyl Ester
Purity
>95.0%(HPLC)(N)
Packaging
5g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
B2073
Product name
N-(tert-Butoxycarbonyl)-L-serine Methyl Ester
Purity
>95.0%(HPLC)(N)
Packaging
25g
Price
$59
Updated
2025/07/31
TRC
Product number
B690850
Product name
N-(tert-Butoxycarbonyl)-L-serine Methyl Ester
Packaging
25g
Price
$275
Updated
2021/12/16
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Boc-L-serine methyl ester Chemical Properties,Usage,Production

Chemical Properties

Liquid

Uses

N-tert-Butoxycarbonyl-L-serine Methyl Ester is an amino acid derivative used in the preparation of Tn antigen, L-glutamic acid p-nitroanilide analogs and new biomedical polymers having Serine and Threonine side groups.

Uses

Boc-L-serine methyl ester is a derivative of L-Serine Methyl Ester Hydrochloride (S271005) derivative. Boc-L-serine methyl ester is an amino acid derivative used in the preparation of Tn antigen, L-glutamic acid p-nitroanilide analogs and new biomedical polymers having Serine and Threonine side groups.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

5680-80-8

2766-43-0

General procedure for the synthesis of Boc-L-serine methyl ester from di-tert-butyl dicarbonate and L-serine methyl ester hydrochloride: crude L-serine methyl ester hydrochloride (0.29 mol) was suspended in dichloromethane (200 mL), followed by the addition of triethylamine (79 mL, 0.57 mol) and di-tert-butyl dicarbonate (68 g, 0.31 mol) to the mixture. The reaction was carried out at 0°C. After removal of the cooling bath, the reaction mixture was stirred at room temperature overnight and then diluted with methyl tert-butyl ether (300 mL). The mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by fast column chromatography on silica gel to afford Boc-L-serine methyl ester (60 g, 94% yield) as a colorless oil.

References

[1] European Journal of Organic Chemistry, 2000, # 1, p. 115 - 124
[2] Organic Letters, 2003, vol. 5, # 24, p. 4599 - 4602
[3] Journal of Organic Chemistry, 2015, vol. 80, # 1, p. 40 - 51
[4] Journal of the American Chemical Society, 2016, vol. 138, # 43, p. 14218 - 14221
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 19, p. 3089 - 3093

Boc-L-serine methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-4-BOC-MORPHOLINE-3-CARBOXYLIC ACID
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View Lastest Price from Boc-L-serine methyl ester manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-L-Ser-OMe 2766-43-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-11-20
Sichuan Jiaying Lai Technology Co.,LTD
Product
Boc-Ser-OMe 2766-43-0
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-21
Career Henan Chemical Co
Product
Boc-L-serine methyl ester 2766-43-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-16

2766-43-0, Boc-L-serine methyl esterRelated Search:

Ethopabate Boc-Ser(tBu)-OH L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE L-Serine L-Homoserine D-Cycloserine BOC-SER-OH Paraquat dichloride Methanol N-Carbobenzyloxyglycine Methyl acrylate Basic Violet 1 DL-Serine Methylparaben Acetonitrile Kresoxim-methyl BOC-D-SERINE METHYL ESTER BOC-L-4-Chlorophe

  • BOC-L-SERINE METHYL ESTER
  • BOC-SERINE-OME
  • BOC-SER-OME
  • N-ALPHA-T-BUTOXYCARBONYL-L-SERINE METHYL ESTER
  • N-BOC-L-SERINE METHYL ESTER
  • N-(TERT-BUTOXYCARBONYL)-L-SERINE METHYL ESTER
  • Butoxycarbonylserinemethylester
  • N-T-BOC-L-SERINE METHYL ESTER
  • BOC-SER-OME, BOC-L-SERINE METHYL ESTER
  • Boc-L-Ser-OMe (oil)
  • N-alpha-t-Butyloxycarbonyl-L-serine methyl ester (oil)
  • BOC-L-SERINE METHYLESTER OIL
  • Boc-L-serine methyl ester, N-(tert-Butoxycarbonyl)-L-serine methyl ester
  • Boc-Ser-OMe(Oil)
  • Methyl N-Boc serinate (S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-hydroxypropanoate
  • N-Boc-L-serine Methyl Ester Boc-Ser-OMe
  • N-t-Butyloxycarbonyl-L-serine Methyl ester
  • Boc-Ser-Me
  • (N-tertbutoxycarbonyl)serine methyl ester
  • DL-(4-NO2)-Phe
  • (S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-hydroxypropanoate
  • Boc-Ser-OMe 95%
  • L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
  • Boc-L-Ser-OMe
  • methyl (2S)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
  • Tert-butyl (S)-1-(methoxycarbonyl)-2-hydroxyethylcarbamate
  • (S)-Boc-2-amino-3-hydroxypropionic acid methyl ester
  • Boc-L-serine methyl ester≥ 98% (HPLC)
  • Boc-L-β-hydroxyalanine methyl ester
  • N-Boc-L-serine Methyl Ester,99%e.e.
  • Boc-DL-Ser.oMe
  • N-(tert-Butoxycarbonyl)-L-serine Methyl Ester , 95.0%(LC&N
  • N-(tert-Butoxycarbonyl)-3-hydroxy-L-alanine methyl ester
  • BOC-L-Serine methyleester
  • (Tert-Butoxy)Carbonyl Ser-OMe (Syrup)
  • methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxypropanoate
  • Boc-Ser-OMe, 95%, for synthesis
  • N-(tert-Butoxycarbonyl)-L-serine Methyl Ester &gt
  • methyl (tert-butoxycarbonyl)-L-serinate
  • Tert butoxycarbonyl-l-serine methyl ester
  • BOC-L-Serine Methyl Ester extrapure, 98%
  • N-[(1,1-Dimethylethoxy)carbonyl]-L-serine methyl ester
  • Boc-L-Ser-OMe-OH
  • N-Boc-L-serine methyl ester, 98%
  • 2766-43-0
  • HOCH2CHNHCO2CCH33CO2CH3
  • Serine
  • Specialty Synthesis
  • Peptide Synthesis
  • Amino Acid Derivatives
  • Boc-Amino Acids
  • Amino Acids (N-Protected)
  • Protected & Labeled Amino Acids
  • Boc-Amino Acids
  • Boc-Amino acid series
  • Amino Acid Derivatives
  • Serine [Ser, S]
  • Boc-Amino Acids and Derivative