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BOC-L-Tyrosine

Product Name
BOC-L-Tyrosine
CAS No.
3978-80-1
Chemical Name
BOC-L-Tyrosine
Synonyms
BOC-TYR-OH;Boc-Tyr;(tert-butoxycarbonyl)-L-tyrosine;BOC-L-TYR-OH;N-BOC-L-TYROSINE;(2S)-3-(4-Hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate;TYRO-006;BOC-TYROSINE;Boc-Tyr-OH 98%;BOC-L-TYROSINE
CBNumber
CB0314497
Molecular Formula
C14H19NO5
Formula Weight
281.3
MOL File
3978-80-1.mol
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BOC-L-Tyrosine Property

Melting point:
133-135 °C(lit.)
alpha 
2.5 º (c=2, acetic acid)
Boiling point:
423.97°C (rough estimate)
Density 
1.1755 (rough estimate)
refractive index 
1.5230 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Sparingly)
pka
2.98±0.10(Predicted)
form 
Powder
color 
White to off-white
optical activity
[α]20/D +3.0°, c = 2 in acetic acid
BRN 
2816406
Major Application
peptide synthesis
InChI
InChI=1S/C14H19NO5/c1-14(2,3)20-13(19)15-11(12(17)18)8-9-4-6-10(16)7-5-9/h4-7,11,16H,8H2,1-3H3,(H,15,19)(H,17,18)/t11-/m0/s1
InChIKey
CNBUSIJNWNXLQQ-NSHDSACASA-N
SMILES
C(O)(=O)[C@H](CC1=CC=C(O)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference
3978-80-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
HS Code 
29242990
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53043
Product name
Boc-Tyr-OH
Purity
Novabiochem?
Packaging
25g
Price
$173
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53043
Product name
Boc-Tyr-OH
Purity
Novabiochem?
Packaging
100g
Price
$536
Updated
2025/07/31
Sigma-Aldrich
Product number
374229
Product name
Boc-Tyr-OH
Purity
98%
Packaging
5g
Price
$77.04
Updated
2025/07/31
TCI Chemical
Product number
B1640
Product name
N-(tert-Butoxycarbonyl)-L-tyrosine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
B1640
Product name
N-(tert-Butoxycarbonyl)-L-tyrosine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$124
Updated
2025/07/31
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BOC-L-Tyrosine Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

N-Boc-L-tyrosine is an N-Boc-protected form of L-Tyrosine (T899975). L-Tyrosine is an essential amino acid that exhibits in vitro antioxidant and antiradical activities. L-Tyrosine is used as a precursor to synthesize catecholamines (e.g. Norepinephrine HCl [N674500]) in human keratinocytes, and also for the synthesis of proteins and thyroid hormones.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

In a dry 50 mL round-bottomed flask, (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid ( 200 mg) was dissolved in dry 1,4 -dioxane ( 10 mL) and H2O (5 mL) ( 2:1 ). NaOH ( 1 M, 5 mL, 5 mmol, 4.5 eq.) and Boc2O ( 0.28 mL, 1.21 mmol) were then added sequentially to the solution. The resulting reaction mixture was stirred at room temperature for 3 h. The progress of the reaction was monitored by LCMS and after waiting for the end of the reaction the reaction solution was acidified with 2 M HCl to a pH of about 2 - 3. The resulting reaction mixture was extracted three times with ethyl acetate ( 3 ?? 25 mL), all the organic layers were combined and the organic layer was washed with brine, the organic layer was separated out and dried with anhydrous Na2SO4, the organic layer was filtered to remove the drying agent, and the resulting organic layer was dried with anhydrous Na2SO4. The organic layer was separated and dried with anhydrous Na2SO4, the organic layer was filtered to remove the desiccant, and the resulting filtrate was concentrated under vacuum to remove the organic solvent, and the crude product was separated and purified by silica gel column chromatography to obtain the target product molecule, N-tert-butoxycarbonyl-L-tyrosine.

BOC-L-Tyrosine Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-L-Tyrosine Suppliers

Americas 1 Belgium 1 China 280 Europe 3 France 2 Germany 6 Hungary 1 India 32 Italy 2 Japan 6 South Korea 1 Switzerland 6 United Kingdom 14 United States 56 Global 411
Shanghai Chiral Chemicals Inc.
Tel
021-37285021 13472570865
Fax
86-021-51714507
Email
tym7xi@aliyun.com
Country
China
ProdList
297
Advantage
64
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44802
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
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View Lastest Price from BOC-L-Tyrosine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-Tyr-OH 3978-80-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-23
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-L-Tyr-OH 3978-80-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-10-07
Hebei Zhuanglai Chemical Trading Co Ltd
Product
BOC-L-Tyrosine 3978-80-1
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-12-02

3978-80-1, BOC-L-TyrosineRelated Search:

N-[(tert-Butoxy)carbonyl]-L-tryptophan Boc-Aib-OH N-BOC-1,6-diaminohexane BOC-METYR(ME)-OH DCHA N-Boc-Ethylenediamine BOC-L-TYROSINE(2-BROMOCBZ) Boc-O-benzyl-L-tyrosine BOC-TYR(2,6-DI-CL-BZL)-OH Boc-Tyr(Me)-OH BOC-L-Tyrosine BOC-TYR(ET)-OH N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine Boc-L-tyrosine methyl ester, N-(tert-Butoxycarbonyl)-L-tyrosine methyl ester,BOC-L-TYROSINE METHYL ESTER,N-BOC-L-TYROSINE METHYL ESTER Boc-D-Tyr-OH BOC-D-TYROSINE(2-BROMO-Z)-OH BOC-L-TYROSINE ETHYL ESTER BOC-D-TYROSINE(BZL)-OH BOC-D-TYROSINE(ET)-OH

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  • 3978-80-1
  • 4HOC6H4CH2CHCOOHNHCOOCCH33
  • Peptide Synthesis
  • Specialty Synthesis
  • Tyrosine
  • Amino Acid Derivatives
  • Amino Acids (N-Protected)
  • Protected & Labeled Amino Acids
  • Boc-Amino Acids
  • Tyrosine [Tyr, Y]
  • Boc-Amino Acids and Derivative
  • Amino Acids (N-Protected)