N-BOC-1,6-diaminohexane
- Product Name
- N-BOC-1,6-diaminohexane
- CAS No.
- 51857-17-1
- Chemical Name
- N-BOC-1,6-diaminohexane
- Synonyms
- tert-Butyl (6-aMinohexyl)carbaMate;N-BOC-1,6-DIAMINOHEXANE;N-BOC-1,6-HEXANEDIAMINE;TERT-BUTYL N-(6-AMINOHEXYL)CARBAMATE;tert-butyl (6-aMinohexyl)carbaMate hydrochloride;AURORA KA-7567;AURORA KA-7545;AURORA KA-4392;Boc-NH-(CH2)6-NH2;TIMTEC-BB SBB006530
- CBNumber
- CB0702254
- Molecular Formula
- C11H24N2O2
- Formula Weight
- 216.32
- MOL File
- 51857-17-1.mol
N-BOC-1,6-diaminohexane Property
- Boiling point:
- 106-110 °C (0.3 mmHg)
- Density
- 0.965 g/mL at 20 °C(lit.)
- refractive index
- n20/D 1.462
- Flash point:
- 125 °C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Soluble in dichloromethane and ethyl acetate.
- pka
- 12.93±0.46(Predicted)
- form
- Viscous Liquid
- color
- Clear light yellow
- Sensitive
- Air Sensitive
- BRN
- 2089264
- InChIKey
- RVZPDKXEHIRFPM-UHFFFAOYSA-N
- CAS DataBase Reference
- 51857-17-1(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2735 8/PG 2
- WGK Germany
- 3
- F
- 10-34
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29241900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 79229
- Product name
- N-Boc-1,6-hexanediamine
- Purity
- ≥98.0% (NT)
- Packaging
- 1g
- Price
- $51.1
- Updated
- 2024/03/01
- Product number
- 79229
- Product name
- N-Boc-1,6-hexanediamine
- Purity
- ≥98.0% (NT)
- Packaging
- 5g
- Price
- $179
- Updated
- 2024/03/01
- Product number
- A1375
- Product name
- N-(tert-Butoxycarbonyl)-1,6-diaminohexane
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $26
- Updated
- 2024/03/01
- Product number
- A1375
- Product name
- N-(tert-Butoxycarbonyl)-1,6-diaminohexane
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $85
- Updated
- 2024/03/01
- Product number
- L19948
- Product name
- N-Boc-1,6-diaminohexane, 98%
- Packaging
- 1g
- Price
- $49.65
- Updated
- 2024/03/01
N-BOC-1,6-diaminohexane Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
N-Boc-1,6-diaminohexane is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.
Application
N-Boc-1,6-hexanediamine can be used as a linear hexyl spacer (C6-spacer) to synthesize:
Biodegradable poly(disulfide amine)s for gene delivery.
A multifunctional dendrimer for theranostics.
Polyamide platinum anti-cancer complexes designed to target cancer specific DNA sequences.
Self-assembled monolayers (SAMs) that resist adsorption of proteins.
[N-(6-(4-Hydroxy-6-isopropylamino-1,3,5-triazin-2-ylamino)hexyl)-5-hydroxy-1,4-naphthoquinone-3-propionamide] (JUG-HATZ), which can be used in designing electrochemical immunosensors.
Preparation
synthesis of N-BOC-1,6-diaminohexane: 1,6-Diaminohexane 3 (Fig. 1) (100 g, 0.86 mol) was dissolved in CH2Cl2 (300 ml) and cooled in an ice bath to 0–3°C. To the stirred solution 0.3 eq. di-tert-butyl bicarbonate (62.6 g, 0.29 mol) was added slowly over a period of 1 h. The reaction was allowed to warm up to r.t., and proceeded overnight. The reaction mixture was extracted with saturated aqueous NaHCO3 (50 ml, three times). The organic phases were pooled, dried, and evaporated under reduced pressure. The resulting oil was dissolved in 200 ml, 1 N HCl and extracted with ether. The aqueous phase was washed with ether, made basic to a pH of 10 with aqueous 2 N NaO3, and extracted with ethyl acetate. The organic phases were pooled, dried, and evaporated under reduced pressure. The resulting oil was dissolved in 200 ml, 1 N HCL and extracted with ether. The aqueous phase was washed with ether, made basic to a pH of 10 with aqueous 2 N NaOH, and extracted with ethyl acetate. The organic extracts were pooled, dried over Na2SO4 and evaporated to give 10.5 g of homogeneous N-BOC-1, 6- diaminohexane 2c (Fig. 1) as a yellow oil which was used without further purification.
TLC Rf 0.51; 1H NMR (CDCL3) d 4.54 (bs, 1H; NH), 3.05 1 2.62 (m, 4H; NCH2), 1.41 (m, 9H; CH3), 1.29 (m, 8H; CH2).
Evaluation of aminoalkylmethacrylate nanoparticles as colloidal drug carrier systems. Part I: synthesis of monomers, dependence of the physical properties on the polymerization methods
N-BOC-1,6-diaminohexane Preparation Products And Raw materials
Raw materials
Preparation Products
N-BOC-1,6-diaminohexane Suppliers
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View Lastest Price from N-BOC-1,6-diaminohexane manufacturers
- Product
- N-tert-Butoxycarbonyl-1,6-hexanediamine 51857-17-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- N-tert-Butoxycarbonyl-1,6-hexanediamine 51857-17-1
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 97-99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-19