N-BOC-1,6-diaminohexane

ChemicalBook > CAS DataBase List > N-BOC-1,6-diaminohexane

N-BOC-1,6-diaminohexane

Product Name: N-BOC-1,6-diaminohexane
CAS No.: 51857-17-1
Chemical Name: N-BOC-1,6-diaminohexane
Synonyms: tert-Butyl (6-aMinohexyl)carbaMate;N-BOC-1,6-DIAMINOHEXANE;N-BOC-1,6-HEXANEDIAMINE;TERT-BUTYL N-(6-AMINOHEXYL)CARBAMATE;tert-butyl (6-aMinohexyl)carbaMate hydrochloride;AURORA KA-7567;AURORA KA-7545;AURORA KA-4392;Boc-NH-(CH2)6-NH2;TIMTEC-BB SBB006530
CBNumber: CB0702254
Molecular Formula: C11H24N2O2
Formula Weight: 216.32
MOL File: 51857-17-1.mol

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N-BOC-1,6-diaminohexane Property

Boiling point:: 106-110 °C (0.3 mmHg)
Density: 0.965 g/mL at 20 °C(lit.)
refractive index: n20/D 1.462
Flash point:: 125 °C
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Soluble in dichloromethane and ethyl acetate.
pka: 12.93±0.46(Predicted)
form: Viscous Liquid
color: Clear light yellow
Sensitive: Air Sensitive
BRN: 2089264
InChIKey: RVZPDKXEHIRFPM-UHFFFAOYSA-N
CAS DataBase Reference: 51857-17-1(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 2735 8/PG 2
WGK Germany: 3
F: 10-34
HazardClass: 8
PackingGroup: III
HS Code: 29241900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 79229
Product name: N-Boc-1,6-hexanediamine
Purity: ≥98.0% (NT)
Packaging: 1g
Price: $51.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 79229
Product name: N-Boc-1,6-hexanediamine
Purity: ≥98.0% (NT)
Packaging: 5g
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: A1375
Product name: N-(tert-Butoxycarbonyl)-1,6-diaminohexane
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $26
Updated: 2024/03/01

TCI Chemical

Product number: A1375
Product name: N-(tert-Butoxycarbonyl)-1,6-diaminohexane
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $85
Updated: 2024/03/01

Alfa Aesar

Product number: L19948
Product name: N-Boc-1,6-diaminohexane, 98%
Packaging: 1g
Price: $49.65
Updated: 2024/03/01

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N-BOC-1,6-diaminohexane Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

N-Boc-1,6-diaminohexane is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.

Application

N-Boc-1,6-hexanediamine can be used as a linear hexyl spacer (C6-spacer) to synthesize:
Biodegradable poly(disulfide amine)s for gene delivery.
A multifunctional dendrimer for theranostics.
Polyamide platinum anti-cancer complexes designed to target cancer specific DNA sequences.
Self-assembled monolayers (SAMs) that resist adsorption of proteins.
[N-(6-(4-Hydroxy-6-isopropylamino-1,3,5-triazin-2-ylamino)hexyl)-5-hydroxy-1,4-naphthoquinone-3-propionamide] (JUG-HATZ), which can be used in designing electrochemical immunosensors.

Preparation

synthesis of N-BOC-1,6-diaminohexane: 1,6-Diaminohexane 3 (Fig. 1) (100 g, 0.86 mol) was dissolved in CH2Cl2 (300 ml) and cooled in an ice bath to 0–3°C. To the stirred solution 0.3 eq. di-tert-butyl bicarbonate (62.6 g, 0.29 mol) was added slowly over a period of 1 h. The reaction was allowed to warm up to r.t., and proceeded overnight. The reaction mixture was extracted with saturated aqueous NaHCO3 (50 ml, three times). The organic phases were pooled, dried, and evaporated under reduced pressure. The resulting oil was dissolved in 200 ml, 1 N HCl and extracted with ether. The aqueous phase was washed with ether, made basic to a pH of 10 with aqueous 2 N NaO3, and extracted with ethyl acetate. The organic phases were pooled, dried, and evaporated under reduced pressure. The resulting oil was dissolved in 200 ml, 1 N HCL and extracted with ether. The aqueous phase was washed with ether, made basic to a pH of 10 with aqueous 2 N NaOH, and extracted with ethyl acetate. The organic extracts were pooled, dried over Na2SO4 and evaporated to give 10.5 g of homogeneous N-BOC-1, 6- diaminohexane 2c (Fig. 1) as a yellow oil which was used without further purification.
TLC Rf 0.51; 1H NMR (CDCL3) d 4.54 (bs, 1H; NH), 3.05 1 2.62 (m, 4H; NCH2), 1.41 (m, 9H; CH3), 1.29 (m, 8H; CH2).
Evaluation of aminoalkylmethacrylate nanoparticles as colloidal drug carrier systems. Part I: synthesis of monomers, dependence of the physical properties on the polymerization methods

N-BOC-1,6-diaminohexane Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-BOC-1,6-diaminohexane manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-tert-Butoxycarbonyl-1,6-hexanediamine 51857-17-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: N-tert-Butoxycarbonyl-1,6-hexanediamine 51857-17-1
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 97-99%
Supply Ability: 1000KGS
Release date: 2019-12-19

51857-17-1, N-BOC-1,6-diaminohexaneRelated Search:

Butyl formate Cyclohexene oxide Urethane tert-Butyl carbazate tert-Butyl 4-aminobenzoate Hexamethylenediamine tert-Butyl carbamate BUTYL OLEATE Methylcyclohexane POLYURETHANE Diisobutyl phthalate Cyhalofop-butyl Chlorpropham tert-Butyl glycinate Hexane 4-Aminobenzoic acid Cyclohexane Buprofezin

AURORA KA-4392

AURORA KA-7545

AURORA KA-7567

TIMTEC-BB SBB006530

TERT-BUTYL N-(6-AMINOHEXYL)CARBAMATE

N-(6-AMINOHEXYL)CARBAMIC ACID TERT-BUTYL ESTER

N-BOC-1,6-DIAMINOHEXANE

N-BOC-1,6-HEXANEDIAMINE

N-(TERT-BUTOXYCARBONYL)-1,6-DIAMINOHEXANE

N-(TERT-BUTOXYCARBONYL)-1,6-HEXANEDIAMINE

1-BOC-AMINO-1,6-HEXANEDIAMINE

1-BOC-1,6-DIAMINOHEXANE

(6-Aminohexyl)carbamic Acid tert-Butyl Ester

1-((tert-Butoxycarbonyl)amino)-6-aminohexane

N-(6-Aminohexyl)-carbamic Acid 1,1-Dimethylethyl Ester

n-(tert-butoxycarbonyl)hexamethylenediamine

N-tert-Butoxycarbonyl-1,6-hexanediamine N-Boc-1,6-diaminohexane N-(6-Aminohexyl)carbamic acid tert-butyl ester tert-butyl 6-aminohexylcarbamate

N-t-BOC-1,6-HEXANEDIAMINE

N-Boc-1,6-diaminohexane, tert-Butyl-N-(6-aminohexyl)carbamate

(6-Aminohexyl)carbamic acid 1,1-dimethylethyl ester

N-(tert-Butoxycarbonyl)hexane-1,6-diamine

N-(6-Aminohexyl)carbamic Acid tert-Butyl Ester N-Boc-1,6-diaminohexane N-Boc-1,6-hexanediamine N-(tert-Butoxycarbonyl)-1,6-hexanediamine tert-Butyl N-(6-Aminohexyl)carbamate

N-Boc-1,6-hexanediaMine 98%

tert-Butyl (6-aMinohexyl)carbaMate

tert-butyl (6-aMinohexyl)carbaMate hydrochloride

N-(tert-Butoxycarbonyl)-1,6-diaMinohexane, 95.0%(GC)

N-Boc-1,6-hexanediamine >=98.0% (GC)

N-tert-Butoxycarbonyl-1,6-hexanediamine,95%

N-(tert-Butoxycarbonyl)-1,6-diaminohexane &gt

Carbamic acid, N-(6-aminohexyl)-, 1,1-dimethylethyl ester

)-1,6-diaminohexane

N-tert-Butoxycarbonyl-1,6-hexanediamine ISO 9001：2015 REACH

NH2C6NHBoc,linker,NH2 C6 NH Boc,NH-2-C6-NH-Boc,inhibit,Inhibitor,PROTAC Linkers,PROTAC,Mcl-1

Boc-NH-(CH2)6-NH2

51857-17-1

51857-17-7

C11H24N2O2

CH33COCONHCH26NH2

C11H25N2O2

Organic Building Blocks

Nitrogen Compounds

Protected Amines

N-Boc-diaminoalkanes

Monoprotected Diaminoalkanes

Building Blocks

All Aliphatics

Monoprotected Diaminoalkanes

N-Boc-diaminoalkanes

Aliphatics

Amines