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N-BOC-1,6-diaminohexane

Product Name
N-BOC-1,6-diaminohexane
CAS No.
51857-17-1
Chemical Name
N-BOC-1,6-diaminohexane
Synonyms
tert-Butyl (6-aMinohexyl)carbaMate;N-BOC-1,6-DIAMINOHEXANE;N-BOC-1,6-HEXANEDIAMINE;TERT-BUTYL N-(6-AMINOHEXYL)CARBAMATE;tert-butyl (6-aMinohexyl)carbaMate hydrochloride;AURORA KA-7567;AURORA KA-7545;AURORA KA-4392;Boc-NH-(CH2)6-NH2;TIMTEC-BB SBB006530
CBNumber
CB0702254
Molecular Formula
C11H24N2O2
Formula Weight
216.32
MOL File
51857-17-1.mol
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N-BOC-1,6-diaminohexane Property

Boiling point:
106-110 °C (0.3 mmHg)
Density 
0.965 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.462
Flash point:
125 °C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in dichloromethane and ethyl acetate.
pka
12.93±0.46(Predicted)
form 
Viscous Liquid
color 
Clear light yellow
Sensitive 
Air Sensitive
BRN 
2089264
InChIKey
RVZPDKXEHIRFPM-UHFFFAOYSA-N
CAS DataBase Reference
51857-17-1(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2735 8/PG 2
WGK Germany 
3
10-34
HazardClass 
8
PackingGroup 
III
HS Code 
29241900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
79229
Product name
N-Boc-1,6-hexanediamine
Purity
≥98.0% (NT)
Packaging
1g
Price
$51.1
Updated
2024/03/01
Sigma-Aldrich
Product number
79229
Product name
N-Boc-1,6-hexanediamine
Purity
≥98.0% (NT)
Packaging
5g
Price
$179
Updated
2024/03/01
TCI Chemical
Product number
A1375
Product name
N-(tert-Butoxycarbonyl)-1,6-diaminohexane
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
A1375
Product name
N-(tert-Butoxycarbonyl)-1,6-diaminohexane
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$85
Updated
2024/03/01
Alfa Aesar
Product number
L19948
Product name
N-Boc-1,6-diaminohexane, 98%
Packaging
1g
Price
$49.65
Updated
2024/03/01
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N-BOC-1,6-diaminohexane Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

N-Boc-1,6-diaminohexane is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.

Application

N-Boc-1,6-hexanediamine can be used as a linear hexyl spacer (C6-spacer) to synthesize:
Biodegradable poly(disulfide amine)s for gene delivery.
A multifunctional dendrimer for theranostics.
Polyamide platinum anti-cancer complexes designed to target cancer specific DNA sequences.
Self-assembled monolayers (SAMs) that resist adsorption of proteins.
[N-(6-(4-Hydroxy-6-isopropylamino-1,3,5-triazin-2-ylamino)hexyl)-5-hydroxy-1,4-naphthoquinone-3-propionamide] (JUG-HATZ), which can be used in designing electrochemical immunosensors.

Preparation

synthesis of N-BOC-1,6-diaminohexane: 1,6-Diaminohexane 3 (Fig. 1) (100 g, 0.86 mol) was dissolved in CH2Cl2 (300 ml) and cooled in an ice bath to 0–3°C. To the stirred solution 0.3 eq. di-tert-butyl bicarbonate (62.6 g, 0.29 mol) was added slowly over a period of 1 h. The reaction was allowed to warm up to r.t., and proceeded overnight. The reaction mixture was extracted with saturated aqueous NaHCO3 (50 ml, three times). The organic phases were pooled, dried, and evaporated under reduced pressure. The resulting oil was dissolved in 200 ml, 1 N HCl and extracted with ether. The aqueous phase was washed with ether, made basic to a pH of 10 with aqueous 2 N NaO3, and extracted with ethyl acetate. The organic phases were pooled, dried, and evaporated under reduced pressure. The resulting oil was dissolved in 200 ml, 1 N HCL and extracted with ether. The aqueous phase was washed with ether, made basic to a pH of 10 with aqueous 2 N NaOH, and extracted with ethyl acetate. The organic extracts were pooled, dried over Na2SO4 and evaporated to give 10.5 g of homogeneous N-BOC-1, 6- diaminohexane 2c (Fig. 1) as a yellow oil which was used without further purification.
TLC Rf 0.51; 1H NMR (CDCL3) d 4.54 (bs, 1H; NH), 3.05 1 2.62 (m, 4H; NCH2), 1.41 (m, 9H; CH3), 1.29 (m, 8H; CH2).
Evaluation of aminoalkylmethacrylate nanoparticles as colloidal drug carrier systems. Part I: synthesis of monomers, dependence of the physical properties on the polymerization methods

N-BOC-1,6-diaminohexane Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-1,6-diaminohexane Suppliers

Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from N-BOC-1,6-diaminohexane manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
N-tert-Butoxycarbonyl-1,6-hexanediamine 51857-17-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
N-tert-Butoxycarbonyl-1,6-hexanediamine 51857-17-1
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
97-99%
Supply Ability
1000KGS
Release date
2019-12-19

51857-17-1, N-BOC-1,6-diaminohexaneRelated Search:


  • AURORA KA-4392
  • AURORA KA-7545
  • AURORA KA-7567
  • TIMTEC-BB SBB006530
  • TERT-BUTYL N-(6-AMINOHEXYL)CARBAMATE
  • N-(6-AMINOHEXYL)CARBAMIC ACID TERT-BUTYL ESTER
  • N-BOC-1,6-DIAMINOHEXANE
  • N-BOC-1,6-HEXANEDIAMINE
  • N-(TERT-BUTOXYCARBONYL)-1,6-DIAMINOHEXANE
  • N-(TERT-BUTOXYCARBONYL)-1,6-HEXANEDIAMINE
  • 1-BOC-AMINO-1,6-HEXANEDIAMINE
  • 1-BOC-1,6-DIAMINOHEXANE
  • (6-Aminohexyl)carbamic Acid tert-Butyl Ester
  • 1-((tert-Butoxycarbonyl)amino)-6-aminohexane
  • N-(6-Aminohexyl)-carbamic Acid 1,1-Dimethylethyl Ester
  • n-(tert-butoxycarbonyl)hexamethylenediamine
  • N-tert-Butoxycarbonyl-1,6-hexanediamine N-Boc-1,6-diaminohexane N-(6-Aminohexyl)carbamic acid tert-butyl ester tert-butyl 6-aminohexylcarbamate
  • N-t-BOC-1,6-HEXANEDIAMINE
  • N-Boc-1,6-diaminohexane, tert-Butyl-N-(6-aminohexyl)carbamate
  • (6-Aminohexyl)carbamic acid 1,1-dimethylethyl ester
  • N-(tert-Butoxycarbonyl)hexane-1,6-diamine
  • N-(6-Aminohexyl)carbamic Acid tert-Butyl Ester N-Boc-1,6-diaminohexane N-Boc-1,6-hexanediamine N-(tert-Butoxycarbonyl)-1,6-hexanediamine tert-Butyl N-(6-Aminohexyl)carbamate
  • N-Boc-1,6-hexanediaMine 98%
  • tert-Butyl (6-aMinohexyl)carbaMate
  • tert-butyl (6-aMinohexyl)carbaMate hydrochloride
  • N-(tert-Butoxycarbonyl)-1,6-diaMinohexane, 95.0%(GC)
  • N-Boc-1,6-hexanediamine >=98.0% (GC)
  • N-tert-Butoxycarbonyl-1,6-hexanediamine,95%
  • N-(tert-Butoxycarbonyl)-1,6-diaminohexane &gt
  • Carbamic acid, N-(6-aminohexyl)-, 1,1-dimethylethyl ester
  • )-1,6-diaminohexane
  • N-tert-Butoxycarbonyl-1,6-hexanediamine ISO 9001:2015 REACH
  • NH2C6NHBoc,linker,NH2 C6 NH Boc,NH-2-C6-NH-Boc,inhibit,Inhibitor,PROTAC Linkers,PROTAC,Mcl-1
  • Boc-NH-(CH2)6-NH2
  • 51857-17-1
  • 51857-17-7
  • C11H24N2O2
  • CH33COCONHCH26NH2
  • C11H25N2O2
  • Organic Building Blocks
  • Nitrogen Compounds
  • Protected Amines
  • N-Boc-diaminoalkanes
  • Monoprotected Diaminoalkanes
  • Building Blocks
  • All Aliphatics
  • Monoprotected Diaminoalkanes
  • N-Boc-diaminoalkanes
  • Aliphatics
  • Amines