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Cyclohexane

Product Name
Cyclohexane
CAS No.
110-82-7
Chemical Name
Cyclohexane
Synonyms
ohexane;NAPHTHENE;Cicloesano;Cyclohesan;cyclohexan;CYCLOHEXANE;cyclohexaan;Cykloheksan;hexamethylen;HEXAMETHYLENE
CBNumber
CB4193601
Molecular Formula
C6H12
Formula Weight
84.16
MOL File
110-82-7.mol
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Cyclohexane Property

Melting point:
4-7 °C (lit.)
Boiling point:
80.7 °C (lit.)
Density 
0.779 g/mL at 25 °C (lit.)
vapor density 
2.9 (vs air)
vapor pressure 
168.8 mm Hg ( 37.7 °C)
refractive index 
n20/D 1.426(lit.)
Flash point:
-1 °F
storage temp. 
Store at +5°C to +30°C.
solubility 
ethanol: miscible(lit.)
form 
Liquid
color 
colorless
Odor
resembling benzene; mild, sweet, resembling chloroform.
Relative polarity
0.006
Odor Threshold
2.5ppm
explosive limit
1.2-8.3%(V)
Water Solubility 
PRACTICALLY INSOLUBLE
FreezingPoint 
6.554℃
λmax
λ: 210 nm Amax: ≤1.00
λ: 220 nm Amax: ≤0.50
λ: 230 nm Amax: ≤0.20
λ: 235 nm Amax: ≤0.10
λ: 240 nm Amax: ≤0.08
λ: 250 nm Amax: ≤0.03
λ: 255 nm Amax: ≤0.01
Merck 
14,2723
BRN 
1900225
Henry's Law Constant
1.03, 1.26, 1.40, 1.77, and 2.23 at 10, 15, 20, 25, and 30 °C, respectively (EPICS, Ashworth et al., 1988) 0.54, 0.69, 0.82, 1.43, and 1.79 at 2.0, 6.0, 10.0, 18.0, and 25.0 °C, respectively (Dewulf et al.,1999)
Exposure limits
TLV-TWA 300 ppm (~1050 mg/m3) (ACGIH, OSHA, and NIOSH); IDLH 10,000 ppm (NIOSH).
InChIKey
XDTMQSROBMDMFD-UHFFFAOYSA-N
CAS DataBase Reference
110-82-7(CAS DataBase Reference)
NIST Chemistry Reference
Cyclohexane(110-82-7)
EPA Substance Registry System
Cyclohexane (110-82-7)
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Safety

Hazard Codes 
F,Xn,N
Risk Statements 
11-38-50/53-65-67-20
Safety Statements 
9-16-25-33-60-61-62
RIDADR 
UN 1145 3/PG 2
WGK Germany 
2
RTECS 
GU6300000
3-10
Autoignition Temperature
500 °F
TSCA 
Yes
HS Code 
2902 11 00
HazardClass 
3
PackingGroup 
II
Hazardous Substances Data
110-82-7(Hazardous Substances Data)
Toxicity
LC in mice: ~60-70 mg/l air (Lazarew)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H304May be fatal if swallowed and enters airways

H313May be harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H361Suspected of damaging fertility or the unborn child

H371May cause damage to organs

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P331Do NOT induce vomiting.

P391Collect spillage. Hazardous to the aquatic environment

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1.02822
Product name
Cyclohexane
Purity
for spectroscopy Uvasol?
Packaging
500 mL
Price
$98.05
Updated
2021/03/22
Sigma-Aldrich
Product number
1.09666
Product name
Cyclohexane
Purity
for analysis EMSURE? ACS,ISO,Reag. Ph Eur
Packaging
1 L
Price
$98.97
Updated
2021/03/22
Sigma-Aldrich
Product number
1.02817
Product name
Cyclohexane
Purity
for gas chromatography ECD and FID SupraSolv?
Packaging
1 L
Price
$101.75
Updated
2021/03/22
Sigma-Aldrich
Product number
1.00667
Product name
Cyclohexane
Purity
for gas chromatography MS SupraSolv?
Packaging
1 L
Price
$101.75
Updated
2021/03/22
Sigma-Aldrich
Product number
1.02832
Product name
Cyclohexane
Purity
EMPLURA?
Packaging
1 L
Price
$59.11
Updated
2021/03/22
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Cyclohexane Chemical Properties,Usage,Production

Description

Cyclohexane is obtained by the distillation of petroleum or by hydrogenation of benzene. It constitutes 0.5–1.0% of petroleum

Chemical Properties

Cyclohexane is a colorless liquid with a mild, sweet odor.

Physical properties

Colorless liquid with a sweet, chloroform-like odor. A detection odor threshold concentration of 2,700 mg/m3 (784 ppmv) was experimentally determined by Dravnieks (1974). An odor threshold concentration of 2.7 ppbv was reported by Nagata and Takeuchi (1990).

Uses

Suitable for HPLC, spectrophotometry, environmental testing

Uses

Solvent for lacquers and resins. Paint and varnish remover. In the extraction of essential oils. In analytical chemistry for mol wt determinations (cryoscopic constant 20.3). In the manufacture of adipic acid, benzene, cyclohexyl chloride, nitrocyclohexane, cyclohexanol and cyclohexanone. In the manufacture of solid fuel for camp stoves. In fungicidal formulations (possesses slight fungicidal action). In the industrial recrystallization of steroids.

Uses

Cyclohexane is a petroleum product obtainedby distilling C4- 400°F boiling rangenaphthas, followed by fractionation andsuperfractionation; also formed by catalytichydrogenation of benzene. It is usedextensively as a solvent for lacquers andresins, as a paint and varnish remover, andin the manufacture of adipic acid, benzene,cyclohexanol, and cyclohexanone.

Definition

A colorless liquid alkane that is commonly used as a solvent and in the production of hexanedioic acid (adipic acid) for the manufacture of nylon. Cyclohexane, itself, is manufactured by the reformation of longer chain hydrocarbons present in crude-oil fractions. It is also interesting from a structural point of view, existing as a ‘puckered’ six-membered ring, having all bonds between carbon atoms at 109.9° (the tetrahedral angle). The molecule undergoes rapid interconversion between two ‘chair-like’ CONFORMATIONS, which are energetically equivalent, passing through a ‘boat-like’ structure of higher energy. It is commonly represented by a hexagon.

Definition

cyclohexane: A colourless liquidcycloalkane, C6H12; r.d. 0.78; m.p.6.5°C; b.p. 81°C. It occurs in petroleumand is made by passing benzeneand hydrogen under pressureover a heated Raney nickel catalyst at150°C, or by the reduction of cyclohexanone.It is used as a solvent andpaint remover and can be oxidizedusing hot concentrated nitric acid tohexanedioic acid (adipic acid). The cyclohexanering is not planar and canadopt boat and chair conformations;in formulae it is representedby a single hexagon.

Definition

ChEBI: An alicyclic hydrocarbon comprising a ring of six carbon atoms; the cyclic form of hexane, used as a raw material in the manufacture of nylon.

Production Methods

Cyclohexane is fractionated from crude oil and may be released wherever petroleum products are refined, stored, and used. Another large source of general release is in exhaust gases from motor vehicles. It is prepared synthetically from benzene, by hydrocracking of cyclopentane, or from toluene by simultaneous dealkylation and double bond hydrogenation.

General Description

A clear colorless liquid with a petroleum-like odor. Used to make nylon, as a solvent, paint remover, and to make other chemicals. Flash point -4°F. Density 6.5 lb / gal (less than water) and insoluble in water. Vapors heavier than air.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Liquid nitrogen dioxide was fed into a nitration column containing hot Cyclohexane, due to an error. An explosion resulted [MCA Case History 128(1962)] Incompatible with strong oxidizers.

Health Hazard

Dizziness, with nausea and vomiting. Concentrated vapor may cause unconsciousness and collapse.

Health Hazard

Cyclohexane is an acute toxicant of loworder. It is an irritant to the eyes and respiratorysystem. Exposure to a 1–2% concentrationin air caused lethargy, drowsiness,and narcosis in test animals. The lethal concentrationfor a 1-hour exposure in mice isestimated at around 30,000 ppm. Ingestionof cyclohexane exhibited low toxic effects intest species. The LD50 values in the literature show a wide variation. It may be detectedfrom its odor at 300 ppm concentration.

Chemical Reactivity

Reactivity with Water: No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Poison by intravenous route, Moderately toxic by ingestion. A systemic irritant by inhalation and ingestion. A skin irritant. Mutation data reported. Flammable liquid. Dangerous fire hazard when exposed to heat or flame; can react with oxidming materials. Moderate explosion hazard in the form of vapor when exposed to flame. When mixed hot with liquid dinitrogen tetraoxide an explosion can result. To fight fire, use foam, CO2, dry chemical, spray, fog. When heated to decomposition it emits acrid smoke and fumes.

Potential Exposure

Cyclohexane is used as a chemical intermediate; as a solvent for fats, oils, waxes, resins, cer- tain synthetic rubbers; and as an extractant of essential oils in the perfume industry.

Carcinogenicity

No tumor-promoting activity was observed in mice receiving one 60 mL application of 0.3% DMBA in benzene followed by a 60 mL application of cyclohexane twice weekly for 50 weeks.

Source

Schauer et al. (1999) reported cyclohexane in a diesel-powered medium-duty truck exhaust at an emission rate of 210 μg/km.
California Phase II reformulated gasoline contained cyclohexane at a concentration of 8,900 mg/kg. Gas-phase tailpipe emission rates from gasoline-powered automobiles with and without catalytic converters were 1.44 and 238.0 mg/km, respectively (Schauer et al., 2002).

Environmental Fate

Biological. Microbial degradation products reported include cyclohexanol (Dugan, 1972; Verschueren, 1983), 1-oxa-2-oxocycloheptane, 6-hydroxyheptanoate, 6-oxohexanoate, adipic acid, acetyl-CoA, succinyl-CoA (quoted, Verschueren, 1983), and cyclohexanone (Dugan, 1972; Keck et al., 1989).
Photolytic. The following rate constants were reported for the reaction of cyclohexane and OH radicals in the atmosphere: 5.38 x 10-12 cm3/molecule?sec at 295 K (Greiner, 1970); 6.7 x 10-12 cm3/molecule?sec at 300 K (Darnall et al., 1978); 6.69 x 10-12 cm3/molecule?sec at 298 (DeMore and Bayes, 1999); 7.0 x 10-12 cm3/molecule?sec (Atkinson et al., 1979); 7.49 x 10-12 cm3/molecule?sec (Atkinson, 1990). A photooxidation reaction rate constant of 1.35 x 10-16 cm3/molecule?sec was reported for the reaction of cyclohexane with NO3 in the atmosphere (Atkinson, 1991).
Chemical/Physical. The gas-phase reaction of cyclohexane with OH radicals in the presence of nitric oxide yielded cyclohexanone and cyclohexyl nitrate as the major products (Aschmann et al., 1997).
Cyclohexane will not hydrolyze because it has no hydrolyzable functional group.

Shipping

UN1145 Cyclohexane, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

It is best to purify it by washing with conc H2SO4 until the washings are colourless, followed by water, aqueous Na2CO3 or 5% NaOH, and again water until neutral. It is then dried with P2O5, Linde type 4A molecular sieves, CaCl2, or MgSO4 then Na and distilled. Cyclohexane has been refluxed with, and distilled from Na, CaH2, LiAlH4 (which also removes peroxides), sodium/potassium alloy, or P2O5. Traces of *benzene can be removed by passage through a column of silica gel that has been freshly heated: this gives material suitable for ultraviolet and infrared spectroscopy. If there is much *benzene in the cyclohexane, most of it can be removed by a preliminary treatment with nitrating acid (a cold mixture of 30mL conc HNO3 and 70mL of conc H2SO4) which converts *benzene into nitrobenzene. The impure cyclohexane and the nitrating acid are placed in an ice bath and stirred vigorously for 15minutes, after which the mixture is allowed to warm to 25o during 1hour. The cyclohexane is decanted, washed several times with 25% NaOH, then water, dried with CaCl2, and distilled from sodium. Carbonyl-containing impurities can be removed as described for chloroform. Other purification procedures include passage through columns of activated alumina and repeated crystallisation by partial freezing. Small quantities may be purified by chromatography on a Dowex 710-Chromosorb W gas-liquid chromatographic column. Flammable liquid. [Sabatier Ind Eng Chem 18 1005 1926, Schefland & Jacobs The Handbook of Organic Solvents (Van Nostrand) p592 1953, Beilstein 5 IV 27.] Rapid purification: Distil, discarding the forerun. Stand distillate over Grade I alumina (5% w/v) or 4A molecular sieves.

Toxicity evaluation

If released to air, cyclohexane will exist solely as a vapor in the ambient atmosphere, and will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals, though direct photolysis is not expected due to the lack of absorption in the environmental spectrum. Volatilization from water surfaces is expected to be an important fate for this compound, and half-lives in a model river and lake are expected to be 3 h and ~3.5 days respectively. Adsorption to suspended solids and sediments is also expected, though hydrolysis in the environment is unlikely due to the lack of hydrolyzable functional groups.
The potential for bioconcentration and bioaccumulation of cyclohexane in aquatic organisms is moderate. It is highly resistant to biodegradation and is catabolized chiefly by cooxidation.

Incompatibilities

May form explosive mixture with air. Contact with oxidizers, nitrogen dioxide, and oxygen can cause fire and explosion hazard. Can explode in heat when mixed with dinitrogen tetraoxide liquid.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

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Cyclohexane Suppliers

Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
Shanghai neon biological technology co., LTD
Tel
021-54252912-8903
Email
leona.xin@forneeds.cn
Country
China
ProdList
4776
Advantage
58
Liaocheng Tongda Chemical Co. LTD
Fax
18963573761
Email
18963573761@163.com
Country
China
ProdList
115
Advantage
58
VWR(Shanghai) Co., Ltd
Tel
400-821-8006
Fax
+86-21-58558801
Email
info_china@vwr.com
Country
China
ProdList
3044
Advantage
75
Nantong Runfeng Petrochemical Co., Ltd
Tel
Fax
0513-55085866
Email
2853167121@qq.com
Country
China
ProdList
2835
Advantage
58
Jinan Trands Chemical Co. LTD
Tel
0531-88770911- ;0531-88770911-
Fax
0531-88770911
Email
277033665@qq.com;1343989492@qq.com
Country
China
ProdList
129
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
021-54890099
Email
shanpel@anpel.com.cn
Country
CHINA
ProdList
1584
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
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View Lastest Price from Cyclohexane manufacturers

Shandong Yanshuo Chemical Co., Ltd.
Product
Cyclohexane 110-82-7
Price
US $200.00/Kg/Drum
Min. Order
12000KG
Purity
99.9%
Supply Ability
500mt/month
Release date
2021-09-17
Hebei Crovell Biotech Co Ltd
Product
Cyclohexane 110-82-7
Price
US $10.70/Kg/Drum
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-07-30
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
Product
cyclohexane 110-82-7
Price
US $150.00/ASSAYS
Min. Order
10g
Purity
more than 99.6%
Supply Ability
500kg/month
Release date
2021-07-29

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