Befunolol

Product Name: Befunolol
CAS No.: 39552-01-7
Chemical Name: Befunolol
Synonyms: Befunolol;Befunolol USP/EP/BP;(±)Befunolol,(±) Befunolol;2-acetyl-7-(2-hyroxy-3-isopropylaminopropoxy)benzofuran;2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran;(-)-2-Acetyl-7-[(S)-2-hydroxy-3-isopropylaminopropoxy]benzofuran;(+)-2-Acetyl-7-[(R)-2-hydroxy-3-isopropylaminopropoxy]benzofuran;7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl ketone;ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl;7-[2-Hydroxy-3-(iso-propylamino)propoxy]-2-benzofuranyl methyl ketone
CBNumber: CB01116973
Molecular Formula: C16H21NO4
Formula Weight: 291.34
MOL File: 39552-01-7.mol

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Befunolol Property

Melting point:: 115°
Boiling point:: 433.35°C (rough estimate)
Density: 1.1049 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), DMSO (Slightly, Heated)
form: Solid
color: White to Off-White
CAS DataBase Reference: 39552-01-7

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Safety

Toxicity: LD50 in mice: 100-105 mg/kg i.v. (Ito)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B131100
Product name: Befunolol
Packaging: 25mg
Price: $180
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008647
Product name: BEFUNOLOL
Purity: 95.00%
Packaging: 5MG
Price: $503.71
Updated: 2021/12/16

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Befunolol Chemical Properties,Usage,Production

Originator

Bentos,Kakenyaku Kako,Japan,1983

Uses

Befunolol is a β-adrenergic blocker with an intrinsic sympathomimetic action. But it can work as a β-adrenergic partial agonist in isolated organs.

Uses

β-Adrenergic blocker used as antiglaucoma agent in ophthalmie solutions

Definition

ChEBI: Befunolol is a member of benzofurans.

Manufacturing Process

To 8.8 g of 2-acetyl-7-hydroxybenzofuran were added 80 ml of epichlorohydrin and 0.2 g of piperidine hydrochloride and the mixture was heated at 105°C for 3 hours. After the reaction, the excess of epichlorohydrin was evaporated and the resultant was distilled under reduced pressure to give 9.3 g of 2-acetyl-7-(2,3-epoxypropoxy)benzofuranhaving a boiling point of 175° to 176°C/0.7 mm Hg. 6 g of the product was dissolved in 30 ml of ethanol and to the solution was added 10 ml of isopropylamine. After refluxing the mixture for 40 minutes, the solvent was evaporated from the reaction mixture. The resulting residue was recrystallized from cyclohexane-acetone to give 6 g of 2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran having a melting point of 115°C.

Therapeutic Function

Beta-adrenergic blocker

Contact allergens

Befunolol was implicated in allergic contact dermatitis due to beta-blocker agents in eye-drops. Crosssensitivity has been described with levobunolol.

Befunolol Preparation Products And Raw materials

Raw materials

Propoxybenzene Cyclohexane Piperidine hydrochloride Epichlorohydrin Benzofuran Isopropylamine

Preparation Products

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Befunolol Suppliers

China 11 India 1 United Kingdom 1 United States 6 Global 19

J & K SCIENTIFIC LTD.

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39552-01-7, BefunololRelated Search:

Sotalol Bisoprolol Isopropylamine 2-ACETYL-7-METHOXYBENZOFURAN Befunolol 1-(7-ETHOXY-1-BENZOFURAN-2-YL)ETHANONE 2-ACETYL-7-HYDROXYBENZOFURAN Befunolol hydrochloride 2-Ethyl-7-methoxybenzofuran, 97% 7-methoxybenzofuran-2-carbaldehyde

1-(7-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2-benzofuranyl)-ethanon

1-(7-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2-benzofuranyl)ethanone

1-[7-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]-2-benzofuranyl]ethanone

2-acetyl-7-(2-hyroxy-3-isopropylaminopropoxy)benzofuran

Befunolol

2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran

Ethanone, 1-[7-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2-benzofuranyl]-

7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl ketone

7-[2-Hydroxy-3-(iso-propylamino)propoxy]-2-benzofuranyl methyl ketone

ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl

(-)-2-Acetyl-7-[(S)-2-hydroxy-3-isopropylaminopropoxy]benzofuran

(+)-2-Acetyl-7-[(R)-2-hydroxy-3-isopropylaminopropoxy]benzofuran

Befunolol USP/EP/BP

(±)Befunolol,(±) Befunolol

39552-01-7

Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals