Gestrinone

Product Name: Gestrinone
CAS No.: 16320-04-0
Chemical Name: Gestrinone
Synonyms: ru2323;r-2323;A-46745;Dimetrose;NeMestran;TridoMose;gestrigone;GESTRINONE;Dimetriose;gestinone.
CBNumber: CB3121391
Molecular Formula: C21H24O2
Formula Weight: 308.41
MOL File: 16320-04-0.mol

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Gestrinone Property

Melting point:: 150-152°C
alpha: D20 +84.6° (c = 0.41 in methanol)
Boiling point:: 388.8°C (rough estimate)
Density: 1.1040 (rough estimate)
refractive index: 1.4900 (estimate)
storage temp.: -20°C Freezer
solubility: DMF:20.0(Max Conc. mg/mL);64.85(Max Conc. mM)
DMSO:35.0(Max Conc. mg/mL);113.48(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);64.85(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:5):0.25(Max Conc. mg/mL);81.06(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.24(Max Conc. mM)
form: A crystalline solid
pka: 12.76±0.40(Predicted)
color: Off-white to light yellow
Merck: 14,4415
Stability:: Hygroscopic
InChI: InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1
InChIKey: BJJXHLWLUDYTGC-ANULTFPQSA-N
SMILES: C1C2C(CC[C@]3([H])C=2C=C[C@@]2(CC)[C@@]3([H])CC[C@]2(C#C)O)=CC(=O)C1
CAS DataBase Reference: 16320-04-0(CAS DataBase Reference)

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Safety

RTECS: JF7964000
Toxicity: mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)GASTROINTESTINAL: OTHER CHANGES,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 701, 1988.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10006488
Product name: Gestrinone
Purity: ≥98%
Packaging: 100mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 10006488
Product name: Gestrinone
Purity: ≥98%
Packaging: 500mg
Price: $459
Updated: 2024/03/01

Cayman Chemical

Product number: 10006488
Product name: Gestrinone
Packaging: 1000mg
Price: $864
Updated: 2024/03/01

Chem-Impex

Product number: 37917
Product name: Gestrinone,≥98%(AssaybyTitration)
Purity: ≥98%(AssaybyTitration)
Packaging: 100MG
Price: $292.36
Updated: 2021/12/16

AvaChem

Product number: 3789
Product name: Gestrinone
Packaging: 100mg
Price: $390
Updated: 2021/12/16

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Gestrinone Chemical Properties,Usage,Production

Description

Gestrinone is a synthetic steroid with antiprogesterone and antiestrogenic activities. It is reported to be useful in the treatment of endometriosis and uterine leiom yomas.

Chemical Properties

Light Yellow Solid

Originator

Roussel UCLAF (France)

Uses

Steroidal antiestrogen, antiprogestogen, analog of Norgestrienone. Antigonadotropin. Controlled substance.

Definition

ChEBI: Gestrinone is an oxo steroid.

brand name

DIMETROSE

Side effects

Gestrinone, like danazol, inhibits the synthesis of estrogens and progestogens and has been used mainly to prepare patients with an endometrial disorder for hysterectomy. Its most common adverse effects are nausea, headache, mood changes, rash, hot flushes, weight gain, and discomfort in the joints and muscles. In some cases, there is evidence of masculinization.

Mode of action

The primary action of gestrinone is on the hypothalamic-pituitary axis, where it inhibits gonadotrophin release with a weak inhibitory effect on its synthesis. It also possesses anti-estrogen activity. The mode of action of gestrinone used for EC is probably inhibition of implantation by acting on the endometrium rather than inhibiting ovulation[1].

References

[1] Xuefeng Gao, Guian Chen, Erruo Wu . “Mechanism of emergency contraception with gestrinone: a preliminary investigation.” Contraception 76 3 (2007): Pages 221-227.

Gestrinone Preparation Products And Raw materials

Raw materials

2-N-BUTOXYETHYL METHACRYLATE Nitrogen Grignard reagent Cyclohexane Pyruvic acid Acetylacetone Double ring Estradiene dione-3-keta Magnesium silicate Pyrrolidine

Preparation Products

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Gestrinone Suppliers

Americas 1 Canada 1 China 82 Europe 1 India 2 Japan 1 United Kingdom 5 United States 8 Global 101

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Chengdu HuaNa Chemicals Co., Ltd.

Tel: 028-86612776; 13699069380
Fax: -
Email: 515238037@qq.com
Country: China
ProdList: 965
Advantage: 55

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View Lastest Price from Gestrinone manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Gestrinone 16320-04-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2023-02-10

Nantong Guangyuan Chemicl Co,Ltd

Product: Gestrinone 16320-04-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-02

Zhuozhou Wenxi import and Export Co., Ltd

Product: Gestrinone 16320-04-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

16320-04-0, GestrinoneRelated Search:

Ethyl acrylate Ethyl formate Ethyl pyruvate ISOXADIFEN-ETHYL Ethyl acetate Ethylparaben Ethanol CHLOROPHOSPHONAZO III Pregnenolone Leuprorelin Mifepristone Trenbolone Progesterone 5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL Gestodene (Z)-Guggulsterone Eltanolone GUGGULSTERONE E

(8s,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

13-ETHYL-17ALPHA-HYDROXY-18,19-DINORPREGNA-4,9,11-TRIEN-20-YN-3-ONE

D-GESTRINONE

GESTRINONE

9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-19-dinorpregna-(17-alpha)-1

ethylnorgestrienone

gestrigone

r-2323

ru2323

CAS16320-04-0 Gestrinone 99%min Dimetriose

Gestrinone 99%min Dimetriose

13-beta-ethyl-17-alpha-ethinyl-17-hydroxy-gona-4,9,11-triene-3-one

13-ethyl-17-alpha-ethinyl-17-hydroxygon-4,9,11-trien-3-one

13-Ethyl-17α-ethynyl-17-hydroxy-4，9，11-gonatrien-3-one

A-46745

Dimetriose

Dimetrose

Nemestran：Tridomose

(17α)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one

13-Ethyl-17α-ethynyl-17β-hydroxygona-4,9,11-trien-3-one

NeMestran

TridoMose

Gestrinone (8S,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

13-ethyl-17-hydroxy-18,19-dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one

19-dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-1

13-Ethyl-17-alpha-ethynyl-17-hydroxygon-4,9,11-trien-3-one

Gestrinone (1.0mg/ml in Acetonitrile)

18,19-Dinorpregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-

Gestrinone USP/EP/BP

4, 9, 11-ESTRATRIEN-17α-ETHYLNY-18-HOMO-17β-OL-3-ONE

gestinone.

16320-04-0

C21H24O2

Hormone

Active Pharmaceutical Ingredients

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids