Uses
ChemicalBook > CAS DataBase List > Pyruvic acid

Pyruvic acid

Uses
Product Name
Pyruvic acid
CAS No.
127-17-3
Chemical Name
Pyruvic acid
Synonyms
pyruvic;NSC 179;CH3COCOOH;FEMA 2970;PYRUVIC ACID;Pyruvia Acid;ACID PYRUVATE;PyruvicAcid>PYRUVIC ACID BRI;PYRORACEMIC ACID
CBNumber
CB5257557
Molecular Formula
C3H4O3
Formula Weight
88.06
MOL File
127-17-3.mol
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Pyruvic acid Property

Melting point:
11-12 °C (lit.)
Boiling point:
165 °C (lit.)
Density 
1.267 g/mL at 25 °C (lit.)
FEMA 
2970 | PYRUVIC ACID
refractive index 
n20/D 1.428(lit.)
Flash point:
183 °F
storage temp. 
2-8°C
solubility 
Miscible with chloroform and methanol.
pka
2.39(at 25℃)
form 
Liquid
color 
Clear colorless to light yellow or amber
PH
1.2 (90g/l, H2O, 20℃)
JECFA Number
936
Merck 
14,8021
BRN 
506211
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. Refrigerate.
InChIKey
LCTONWCANYUPML-UHFFFAOYSA-N
CAS DataBase Reference
127-17-3(CAS DataBase Reference)
NIST Chemistry Reference
Pyruvic acid(127-17-3)
EPA Substance Registry System
Propanoic acid, 2-oxo- (127-17-3)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45-25-27
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
RTECS 
UZ0829800
Autoignition Temperature
305 °C
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29335995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H227Combustible liquid

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
107360
Product name
Pyruvic acid
Purity
98%
Packaging
25g
Price
$46.4
Updated
2021/03/22
Sigma-Aldrich
Product number
8.20170
Product name
Pyruvic acid
Purity
for synthesis
Packaging
100 mL
Price
$62.44
Updated
2021/03/22
Sigma-Aldrich
Product number
107360
Product name
Pyruvic acid
Purity
98%
Packaging
100g
Price
$73.3
Updated
2021/03/22
Sigma-Aldrich
Product number
W297070
Product name
Pyruvic acid
Purity
natural, ≥95%, FG
Packaging
25 g
Price
$85
Updated
2021/03/22
Sigma-Aldrich
Product number
W297003
Product name
Pyruvic acid
Purity
≥97%, FG
Packaging
250 g
Price
$88.9
Updated
2021/03/22
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Pyruvic acid Chemical Properties,Usage,Production

Uses

Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease.

Chemical Properties

Colorless to light yellow liquid

Chemical Properties

Pyruvic acid has a sour, acetic odor (similar to acetic acid). It has a pleasant, sour taste with a burning, somewhat sweet note. It tends to darken and decompose unless kept free of minor contaminants and in tightly sealed containers

Occurrence

Isolated from cane sugar fermentation broth and from a few plants; also reported found in peppermint, raw asparagus, leaves and stalk of celery, onion, rutabaga, milk, cream, buttermilk, wheaten bread, blue cheeses, cheddar cheese, cottage cheese, provolone cheese, yogurt, beef, Virginia tobacco, beer, white wine, botrytised wine, cocoa and sake.

Uses

pyruvic acid is an alpha hydroxy acid that can be irritating and is considered difficult to work with. It has a larger molecular size than the most commonly used AHAs. Sodium pyruvate is more commonly used, and is an organic salt.

Uses

Biochemical research.

Definition

A fundamen- tal intermediate in protein and carbohydrate metabolism in the cell.

Preparation

By distillation of tartaric acid in the presence of potassium acid sulfate as a dehydrating agent; from acetyl chloride and potassium cyanide to yield the nitrile, which is subsequently acid hydrolyzed to the acid; pyruvic acid must be rectified under vacuum.

Aroma threshold values

Aroma characteristics at 1.0%: acidic, sweet, caramellic and sour.

Taste threshold values

Taste characteristics at 5 ppm: sharp acidic, sour fruity, with sour creamy and caramellic nuances.

Biotechnological Applications

Pyruvic acid is a key position in cell metabolism and is involved in many catabolic and anabolic pathways, including glycolysis, gluconeogenesis, amino acid, and protein metabolism. Pyruvic acid is employed for the production of L-tryptophan, L-tyrosine, and 3,4-dihydroxyphenyl alanine in various industries. The diet supplementation with pyruvic acid increased fat loss and minimized the associated loss of body protein. Pyruvic acid is also used in biochemical researches and medicine as a substrate for assaying activities of such enzymes as pyruvate dehydrogenase, pyruvate carboxylase, and pyruvate decarboxylase (Nakazawa et al. 1972; Yamada et al. 1972; Stanko et al. 1992).
Y. lipolytica oxidize glucose and form pyruvic acid (75–80 %) and a-ketoglutaric acid (20–25 %) under thiamine deficiency conditions. The synthesis of the acid was triggered by a decrease in intracellular thiamine concentration to 3.0 lg per 1 g biomass. An approximately 3-fold increase in the amount of the biomass was associated with a subsequent decrease in thiamine content to the level of 1.0 lg per 1 g biomass, whose maximum production of pyruvic acid was 50 g/L in this condition. In addition to glucose, thiamine-auxotrophic yeasts are capable of synthesizing pyruvic acid when grown on glycerol and propionic acid. Technicalgrade glycerol is the most promising raw material for pyruvic acid production. Pyruvic acid was obtained at a concentration of 61 g/L with a yield of 71 % from glycerol (Morgunov et al. 2004; Finogenova et al. 2005).

Purification Methods

Distil it twice, then fractionally crystallise it by partial freezing. [Beilstein 3 IV 1505.]

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Pyruvic acid Suppliers

Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799(To 20)
Fax
0539-6362799(To 20)
Email
68188893@qq.com
Country
China
ProdList
10009
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
+86-21-56791066;56795766;56795797
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9355
Advantage
58
Shanghai lian lu industrial co., LTD
Tel
021-57937586-
Email
lianluxs013@shllgf.com
Country
China
ProdList
21
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950- ;020-81215950-
Email
customer@uwalab.com;customer@uwalab.com
Country
United States
ProdList
10423
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066-400;021-60496031
Fax
021-55660885
Email
sales@jonln.com;sales@jonln.com
Country
China
ProdList
1999
Advantage
65
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
Country
China
ProdList
3392
Advantage
62
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View Lastest Price from Pyruvic acid manufacturers

Wuhan Mulei New Material Technology Co. Ltd
Product
Pyruvic acid 127-17-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99.9%
Supply Ability
100000kg per month
Release date
2021-04-01
Baoji Guokang Healthchem co.,ltd
Product
Pyruvic acid 127-17-3
Price
US $650.00/kg/bag
Min. Order
25公斤/袋
Purity
99%
Supply Ability
55200T
Release date
2021-06-07
Anhui Rencheng Technology Co., Ltd
Product
Pyruvic acid 127-17-3
Price
US $10.00-15.00/KG
Min. Order
0.5KG
Purity
>99%
Supply Ability
20tons
Release date
2021-01-09

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